Aging of the neuroendocrine system: Impaired neuropeptide control of thyroid stimulating hormone

Theodor J. Theodoropolous; Miguel A. Pappolla

doi:10.1007/BF02432379

Aging of the neuroendocrine system: Impaired neuropeptide control of thyroid stimulating hormone

Theodor J. Theodoropolous, Miguel A. Pappolla

Research output: Contribution to journal › Article › peer-review

Abstract

Previous studies on neuroendocrine feedback control have shown that normal pituitary-thyroid function depends on appropriate hypothalamic regulation. Yet, mechanisms leading to low thyroid stimulating hormone (TSH) in face of low thyroid hormone levels in senescent animals remain to be elucidated. In this study, TSH response in the aging rat was investigated following immunological blockade of endogenous thyrotropin releasing hormone (TRH). TRH blockade in aged rats was not accompanied by the striking reduction in TSH levels observed in young animals. Our data suggest that the normal regulatory functions of endogenous TRH on TSH secretion are altered in the aging rat.

Original language	English (US)
Pages (from-to)	37-38
Number of pages	2
Journal	AGE
Volume	13
Issue number	2
DOIs	https://doi.org/10.1007/BF02432379
State	Published - Apr 1990
Externally published	Yes

ASJC Scopus subject areas

Aging
Geriatrics and Gerontology

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10.1007/BF02432379

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abstract = "Previous studies on neuroendocrine feedback control have shown that normal pituitary-thyroid function depends on appropriate hypothalamic regulation. Yet, mechanisms leading to low thyroid stimulating hormone (TSH) in face of low thyroid hormone levels in senescent animals remain to be elucidated. In this study, TSH response in the aging rat was investigated following immunological blockade of endogenous thyrotropin releasing hormone (TRH). TRH blockade in aged rats was not accompanied by the striking reduction in TSH levels observed in young animals. Our data suggest that the normal regulatory functions of endogenous TRH on TSH secretion are altered in the aging rat.",

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AB - Previous studies on neuroendocrine feedback control have shown that normal pituitary-thyroid function depends on appropriate hypothalamic regulation. Yet, mechanisms leading to low thyroid stimulating hormone (TSH) in face of low thyroid hormone levels in senescent animals remain to be elucidated. In this study, TSH response in the aging rat was investigated following immunological blockade of endogenous thyrotropin releasing hormone (TRH). TRH blockade in aged rats was not accompanied by the striking reduction in TSH levels observed in young animals. Our data suggest that the normal regulatory functions of endogenous TRH on TSH secretion are altered in the aging rat.

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Aging of the neuroendocrine system: Impaired neuropeptide control of thyroid stimulating hormone

Abstract

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