Aging of the neuroendocrine system: Impaired neuropeptide control of thyroid stimulating hormone

Theodor J. Theodoropolous, Miguel Pappolla

Research output: Contribution to journalArticle

Abstract

Previous studies on neuroendocrine feedback control have shown that normal pituitary-thyroid function depends on appropriate hypothalamic regulation. Yet, mechanisms leading to low thyroid stimulating hormone (TSH) in face of low thyroid hormone levels in senescent animals remain to be elucidated. In this study, TSH response in the aging rat was investigated following immunological blockade of endogenous thyrotropin releasing hormone (TRH). TRH blockade in aged rats was not accompanied by the striking reduction in TSH levels observed in young animals. Our data suggest that the normal regulatory functions of endogenous TRH on TSH secretion are altered in the aging rat.

Original languageEnglish (US)
Pages (from-to)37-38
Number of pages2
JournalAge
Volume13
Issue number2
DOIs
StatePublished - Apr 1990
Externally publishedYes

Fingerprint

Neurosecretory Systems
Thyrotropin
Neuropeptides
Thyrotropin-Releasing Hormone
Thyroid Hormones
Thyroid Gland

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Aging of the neuroendocrine system : Impaired neuropeptide control of thyroid stimulating hormone. / Theodoropolous, Theodor J.; Pappolla, Miguel.

In: Age, Vol. 13, No. 2, 04.1990, p. 37-38.

Research output: Contribution to journalArticle

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