Agreement between spectral-domain and time-domain OCT for measuring RNFL thickness

G. Vizzeri, R. N. Weinreb, A. O. Gonzalez-Garcia, C. Bowd, F. A. Medeiros, P. A. Sample, L. M. Zangwill

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143 Scopus citations

Abstract

Background/aims: To evaluate spectral-domain (SD) optical coherence tomography (OCT) reproducibility and assess the agreement between SD-OCT and Time-Domain (TD) OCT retinal nerve fibre layer (RNFL) measurements. Methods: Three Cirrus-SD-OCT scans and one Stratus-TD-OCT scan were obtained from Diagnostic Innovations in Glaucoma Study (DIGS) healthy participants and glaucoma patients on the same day. Repeatability was evaluated using Sw (within-subject standard deviation), CV (coefficient of variation) and ICC (intraclass correlation coefficient). Agreement was assessed using correlation and Bland-Altman plots. Results: 16 healthy participants (32 eyes) and 39 patients (78 eyes) were included. SD-OCT reproducibility was excellent in both groups. The CV and ICC for Average RNFL thickness were 1.5% and 0.96, respectively, in healthy eyes and 1.6% and 0.98, respectively, in patient eyes. Correlations between RNFL parameters were strong, particularly for average RNFL thickness (R2 = 0.92 in patient eyes). Bland-Altman plots showed good agreement between instruments, with better agreement for average RNFL thickness than for sectoral RNFL parameters (for example, at 90 μm average RNFL thickness, 95% limits of agreement were -13.1 to 0.9 for healthy eyes and -16.2 to -0.3 μm for patient eyes). Conclusions: SD-OCT measurements were highly repeatable in healthy and patient eyes. Although the agreement between instruments was good, TD-OCT provided thicker RNFL measurements than SD-OCT. Measurements with these instruments should not be considered interchangeable.

Original languageEnglish (US)
Pages (from-to)775-781
Number of pages7
JournalBritish Journal of Ophthalmology
Volume93
Issue number6
DOIs
StatePublished - Jun 2009

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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    Vizzeri, G., Weinreb, R. N., Gonzalez-Garcia, A. O., Bowd, C., Medeiros, F. A., Sample, P. A., & Zangwill, L. M. (2009). Agreement between spectral-domain and time-domain OCT for measuring RNFL thickness. British Journal of Ophthalmology, 93(6), 775-781. https://doi.org/10.1136/bjo.2008.150698