Agreement for Detecting Glaucoma Progression with the GDx Guided Progression Analysis, Automated Perimetry, and Optic Disc Photography

Luciana M. Alencar, Linda M. Zangwill, Robert N. Weinreb, Christopher Bowd, Gianmarco Vizzeri, Pamela A. Sample, Remo Susanna, Felipe A. Medeiros

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Purpose: To evaluate the ability of the GDx Variable Corneal Compensation (VCC) Guided Progression Analysis (GPA) software for detecting glaucomatous progression. Design: Observational cohort study. Participants: The study included 453 eyes from 252 individuals followed for an average of 46±14 months as part of the Diagnostic Innovations in Glaucoma Study. At baseline, 29% of the eyes were classified as glaucomatous, 67% of the eyes were classified as suspects, and 5% of the eyes were classified as healthy. Methods: Images were obtained annually with the GDx VCC and analyzed for progression using the Fast Mode of the GDx GPA software. Progression using conventional methods was determined by the GPA software for standard automated achromatic perimetry (SAP) and by masked assessment of optic disc stereophotographs by expert graders. Main Outcome Measures: Sensitivity, specificity, and likelihood ratios (LRs) for detection of glaucoma progression using the GDx GPA were calculated with SAP and optic disc stereophotographs used as reference standards. Agreement among the different methods was reported using the AC1 coefficient. Results: Thirty-four of the 431 glaucoma and glaucoma suspect eyes (8%) showed progression by SAP or optic disc stereophotographs. The GDx GPA detected 17 of these eyes for a sensitivity of 50%. Fourteen eyes showed progression only by the GDx GPA with a specificity of 96%. Positive and negative LRs were 12.5 and 0.5, respectively. None of the healthy eyes showed progression by the GDx GPA, with a specificity of 100% in this group. Inter-method agreement (AC1 coefficient and 95% confidence intervals) for non-progressing and progressing eyes was 0.96 (0.94-0.97) and 0.44 (0.28-0.61), respectively. Conclusions: The GDx GPA detected glaucoma progression in a significant number of cases showing progression by conventional methods, with high specificity and high positive LRs. Estimates of the accuracy for detecting progression suggest that the GDx GPA could be used to complement clinical evaluation in the detection of longitudinal change in glaucoma. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.

Original languageEnglish (US)
Pages (from-to)462-470
Number of pages9
JournalOphthalmology
Volume117
Issue number3
DOIs
StatePublished - Mar 2010
Externally publishedYes

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Visual Field Tests
Photography
Optic Disk
Glaucoma
Software
Disclosure
Ocular Hypertension
Observational Studies
Cohort Studies
Outcome Assessment (Health Care)
Confidence Intervals
Sensitivity and Specificity

ASJC Scopus subject areas

  • Ophthalmology

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Agreement for Detecting Glaucoma Progression with the GDx Guided Progression Analysis, Automated Perimetry, and Optic Disc Photography. / Alencar, Luciana M.; Zangwill, Linda M.; Weinreb, Robert N.; Bowd, Christopher; Vizzeri, Gianmarco; Sample, Pamela A.; Susanna, Remo; Medeiros, Felipe A.

In: Ophthalmology, Vol. 117, No. 3, 03.2010, p. 462-470.

Research output: Contribution to journalArticle

Alencar, Luciana M. ; Zangwill, Linda M. ; Weinreb, Robert N. ; Bowd, Christopher ; Vizzeri, Gianmarco ; Sample, Pamela A. ; Susanna, Remo ; Medeiros, Felipe A. / Agreement for Detecting Glaucoma Progression with the GDx Guided Progression Analysis, Automated Perimetry, and Optic Disc Photography. In: Ophthalmology. 2010 ; Vol. 117, No. 3. pp. 462-470.
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abstract = "Purpose: To evaluate the ability of the GDx Variable Corneal Compensation (VCC) Guided Progression Analysis (GPA) software for detecting glaucomatous progression. Design: Observational cohort study. Participants: The study included 453 eyes from 252 individuals followed for an average of 46±14 months as part of the Diagnostic Innovations in Glaucoma Study. At baseline, 29{\%} of the eyes were classified as glaucomatous, 67{\%} of the eyes were classified as suspects, and 5{\%} of the eyes were classified as healthy. Methods: Images were obtained annually with the GDx VCC and analyzed for progression using the Fast Mode of the GDx GPA software. Progression using conventional methods was determined by the GPA software for standard automated achromatic perimetry (SAP) and by masked assessment of optic disc stereophotographs by expert graders. Main Outcome Measures: Sensitivity, specificity, and likelihood ratios (LRs) for detection of glaucoma progression using the GDx GPA were calculated with SAP and optic disc stereophotographs used as reference standards. Agreement among the different methods was reported using the AC1 coefficient. Results: Thirty-four of the 431 glaucoma and glaucoma suspect eyes (8{\%}) showed progression by SAP or optic disc stereophotographs. The GDx GPA detected 17 of these eyes for a sensitivity of 50{\%}. Fourteen eyes showed progression only by the GDx GPA with a specificity of 96{\%}. Positive and negative LRs were 12.5 and 0.5, respectively. None of the healthy eyes showed progression by the GDx GPA, with a specificity of 100{\%} in this group. Inter-method agreement (AC1 coefficient and 95{\%} confidence intervals) for non-progressing and progressing eyes was 0.96 (0.94-0.97) and 0.44 (0.28-0.61), respectively. Conclusions: The GDx GPA detected glaucoma progression in a significant number of cases showing progression by conventional methods, with high specificity and high positive LRs. Estimates of the accuracy for detecting progression suggest that the GDx GPA could be used to complement clinical evaluation in the detection of longitudinal change in glaucoma. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.",
author = "Alencar, {Luciana M.} and Zangwill, {Linda M.} and Weinreb, {Robert N.} and Christopher Bowd and Gianmarco Vizzeri and Sample, {Pamela A.} and Remo Susanna and Medeiros, {Felipe A.}",
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AU - Alencar, Luciana M.

AU - Zangwill, Linda M.

AU - Weinreb, Robert N.

AU - Bowd, Christopher

AU - Vizzeri, Gianmarco

AU - Sample, Pamela A.

AU - Susanna, Remo

AU - Medeiros, Felipe A.

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N2 - Purpose: To evaluate the ability of the GDx Variable Corneal Compensation (VCC) Guided Progression Analysis (GPA) software for detecting glaucomatous progression. Design: Observational cohort study. Participants: The study included 453 eyes from 252 individuals followed for an average of 46±14 months as part of the Diagnostic Innovations in Glaucoma Study. At baseline, 29% of the eyes were classified as glaucomatous, 67% of the eyes were classified as suspects, and 5% of the eyes were classified as healthy. Methods: Images were obtained annually with the GDx VCC and analyzed for progression using the Fast Mode of the GDx GPA software. Progression using conventional methods was determined by the GPA software for standard automated achromatic perimetry (SAP) and by masked assessment of optic disc stereophotographs by expert graders. Main Outcome Measures: Sensitivity, specificity, and likelihood ratios (LRs) for detection of glaucoma progression using the GDx GPA were calculated with SAP and optic disc stereophotographs used as reference standards. Agreement among the different methods was reported using the AC1 coefficient. Results: Thirty-four of the 431 glaucoma and glaucoma suspect eyes (8%) showed progression by SAP or optic disc stereophotographs. The GDx GPA detected 17 of these eyes for a sensitivity of 50%. Fourteen eyes showed progression only by the GDx GPA with a specificity of 96%. Positive and negative LRs were 12.5 and 0.5, respectively. None of the healthy eyes showed progression by the GDx GPA, with a specificity of 100% in this group. Inter-method agreement (AC1 coefficient and 95% confidence intervals) for non-progressing and progressing eyes was 0.96 (0.94-0.97) and 0.44 (0.28-0.61), respectively. Conclusions: The GDx GPA detected glaucoma progression in a significant number of cases showing progression by conventional methods, with high specificity and high positive LRs. Estimates of the accuracy for detecting progression suggest that the GDx GPA could be used to complement clinical evaluation in the detection of longitudinal change in glaucoma. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.

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