Airway obstruction during exercise and isocapnic hyperventilation in asthmatic subjects

Oscar Suman, Kenneth C. Beck, Mark A. Babcock, David F. Pegelow, William G. Reddan

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We compared pulmonary mechanics measured during long-term exercise (LTX = 20 min) with long-term isocapnic hyperventilation (LTIH = 20 min) in the same asthmatic individuals (n = 6). Peak expiratory flow (PEF) and forced expiratory volume in i s (FEV1) decreased during LTX (-19.7 and -22.0%, respectively) and during LTIH (-6.66 and 10.9%, respectively). In contrast, inspiratory pulmonary resistance (RL(I)) was elevated during LTX (57.6%) but not during LTIH (9.62%). As expected, airway function deteriorated post-LTX and post-LTIH (FEV1 = -30.2 and -21.2%; RL(I) = 111.8 and 86.5%, respectively). We conclude that the degree of airway obstruction observed during LTX is of a greater magnitude than that observed during LTIH. Both modes of hyperpnea induced similar levels of airway obstruction in the posthyperpnea period. However, the greater airway obstruction during LTX suggests that a different process may be responsible for the changes in airway function during and after the two modes of hyperpnea. This finding raises questions about the equivalency of LTIH and LTX in the study of airway function during exercise-induced asthma.

Original languageEnglish (US)
Pages (from-to)1107-1113
Number of pages7
JournalJournal of Applied Physiology
Volume87
Issue number3
StatePublished - Sep 1999
Externally publishedYes

Fingerprint

Hyperventilation
Airway Obstruction
Exercise-Induced Asthma
Lung
Forced Expiratory Volume
Mechanics

Keywords

  • Exercise-induced asthma
  • Pulmonary resistance

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Suman, O., Beck, K. C., Babcock, M. A., Pegelow, D. F., & Reddan, W. G. (1999). Airway obstruction during exercise and isocapnic hyperventilation in asthmatic subjects. Journal of Applied Physiology, 87(3), 1107-1113.

Airway obstruction during exercise and isocapnic hyperventilation in asthmatic subjects. / Suman, Oscar; Beck, Kenneth C.; Babcock, Mark A.; Pegelow, David F.; Reddan, William G.

In: Journal of Applied Physiology, Vol. 87, No. 3, 09.1999, p. 1107-1113.

Research output: Contribution to journalArticle

Suman, O, Beck, KC, Babcock, MA, Pegelow, DF & Reddan, WG 1999, 'Airway obstruction during exercise and isocapnic hyperventilation in asthmatic subjects', Journal of Applied Physiology, vol. 87, no. 3, pp. 1107-1113.
Suman, Oscar ; Beck, Kenneth C. ; Babcock, Mark A. ; Pegelow, David F. ; Reddan, William G. / Airway obstruction during exercise and isocapnic hyperventilation in asthmatic subjects. In: Journal of Applied Physiology. 1999 ; Vol. 87, No. 3. pp. 1107-1113.
@article{cd6e1546813340be819b9b1e61a3a80f,
title = "Airway obstruction during exercise and isocapnic hyperventilation in asthmatic subjects",
abstract = "We compared pulmonary mechanics measured during long-term exercise (LTX = 20 min) with long-term isocapnic hyperventilation (LTIH = 20 min) in the same asthmatic individuals (n = 6). Peak expiratory flow (PEF) and forced expiratory volume in i s (FEV1) decreased during LTX (-19.7 and -22.0{\%}, respectively) and during LTIH (-6.66 and 10.9{\%}, respectively). In contrast, inspiratory pulmonary resistance (RL(I)) was elevated during LTX (57.6{\%}) but not during LTIH (9.62{\%}). As expected, airway function deteriorated post-LTX and post-LTIH (FEV1 = -30.2 and -21.2{\%}; RL(I) = 111.8 and 86.5{\%}, respectively). We conclude that the degree of airway obstruction observed during LTX is of a greater magnitude than that observed during LTIH. Both modes of hyperpnea induced similar levels of airway obstruction in the posthyperpnea period. However, the greater airway obstruction during LTX suggests that a different process may be responsible for the changes in airway function during and after the two modes of hyperpnea. This finding raises questions about the equivalency of LTIH and LTX in the study of airway function during exercise-induced asthma.",
keywords = "Exercise-induced asthma, Pulmonary resistance",
author = "Oscar Suman and Beck, {Kenneth C.} and Babcock, {Mark A.} and Pegelow, {David F.} and Reddan, {William G.}",
year = "1999",
month = "9",
language = "English (US)",
volume = "87",
pages = "1107--1113",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "3",

}

TY - JOUR

T1 - Airway obstruction during exercise and isocapnic hyperventilation in asthmatic subjects

AU - Suman, Oscar

AU - Beck, Kenneth C.

AU - Babcock, Mark A.

AU - Pegelow, David F.

AU - Reddan, William G.

PY - 1999/9

Y1 - 1999/9

N2 - We compared pulmonary mechanics measured during long-term exercise (LTX = 20 min) with long-term isocapnic hyperventilation (LTIH = 20 min) in the same asthmatic individuals (n = 6). Peak expiratory flow (PEF) and forced expiratory volume in i s (FEV1) decreased during LTX (-19.7 and -22.0%, respectively) and during LTIH (-6.66 and 10.9%, respectively). In contrast, inspiratory pulmonary resistance (RL(I)) was elevated during LTX (57.6%) but not during LTIH (9.62%). As expected, airway function deteriorated post-LTX and post-LTIH (FEV1 = -30.2 and -21.2%; RL(I) = 111.8 and 86.5%, respectively). We conclude that the degree of airway obstruction observed during LTX is of a greater magnitude than that observed during LTIH. Both modes of hyperpnea induced similar levels of airway obstruction in the posthyperpnea period. However, the greater airway obstruction during LTX suggests that a different process may be responsible for the changes in airway function during and after the two modes of hyperpnea. This finding raises questions about the equivalency of LTIH and LTX in the study of airway function during exercise-induced asthma.

AB - We compared pulmonary mechanics measured during long-term exercise (LTX = 20 min) with long-term isocapnic hyperventilation (LTIH = 20 min) in the same asthmatic individuals (n = 6). Peak expiratory flow (PEF) and forced expiratory volume in i s (FEV1) decreased during LTX (-19.7 and -22.0%, respectively) and during LTIH (-6.66 and 10.9%, respectively). In contrast, inspiratory pulmonary resistance (RL(I)) was elevated during LTX (57.6%) but not during LTIH (9.62%). As expected, airway function deteriorated post-LTX and post-LTIH (FEV1 = -30.2 and -21.2%; RL(I) = 111.8 and 86.5%, respectively). We conclude that the degree of airway obstruction observed during LTX is of a greater magnitude than that observed during LTIH. Both modes of hyperpnea induced similar levels of airway obstruction in the posthyperpnea period. However, the greater airway obstruction during LTX suggests that a different process may be responsible for the changes in airway function during and after the two modes of hyperpnea. This finding raises questions about the equivalency of LTIH and LTX in the study of airway function during exercise-induced asthma.

KW - Exercise-induced asthma

KW - Pulmonary resistance

UR - http://www.scopus.com/inward/record.url?scp=0032859391&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032859391&partnerID=8YFLogxK

M3 - Article

VL - 87

SP - 1107

EP - 1113

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 3

ER -