Albumin kinetics in patients with chronic thoracic duct fistulas

Linea A. McNeel, Courtney Townsend, Jay C. Fish

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In a group of patients with thoracic duct fistulas (TDF) undergoing lymphocyte depletion in preparation for renal transplantation, hypoalbuminemia developed despite replacement of all lymph. Albumin kinetics were measured in ten of these patients and compared with eight similar patients treated in a home dialysis program and seven normal control subjects. Albumin concentration averaged 2.7 Gm. percent in the TDF group compared to 4.0 Gm. percent in the other two groups. The total exchangeable albumin was also reduced in the TDF group when compared to the home dialysis group. An increased catabolic rate as measured by a shortened albumin half-life and accelerated albumin turnover rate accounted for the hypoalbuminemia. It is suggested that the increased catabolism is due to an increased intestinal loss resulting from partial lymphatic obstruction from the thoracic duct cannula. Six weeks following discontinuation of the TDF, the serum albumin concentration returned to normal level.

Original languageEnglish (US)
Pages (from-to)344-347
Number of pages4
JournalSurgery
Volume74
Issue number3
StatePublished - 1973

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Thoracic Duct
Fistula
Albumins
Hypoalbuminemia
Dialysis
Lymphocyte Depletion
Group Homes
Lymph
Serum Albumin
Kidney Transplantation
Half-Life

ASJC Scopus subject areas

  • Surgery

Cite this

McNeel, L. A., Townsend, C., & Fish, J. C. (1973). Albumin kinetics in patients with chronic thoracic duct fistulas. Surgery, 74(3), 344-347.

Albumin kinetics in patients with chronic thoracic duct fistulas. / McNeel, Linea A.; Townsend, Courtney; Fish, Jay C.

In: Surgery, Vol. 74, No. 3, 1973, p. 344-347.

Research output: Contribution to journalArticle

McNeel, LA, Townsend, C & Fish, JC 1973, 'Albumin kinetics in patients with chronic thoracic duct fistulas', Surgery, vol. 74, no. 3, pp. 344-347.
McNeel, Linea A. ; Townsend, Courtney ; Fish, Jay C. / Albumin kinetics in patients with chronic thoracic duct fistulas. In: Surgery. 1973 ; Vol. 74, No. 3. pp. 344-347.
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