Alcohol and Fatty Acid Ethyl Esters

Raneem O. Salem, Michael Laposata

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

This chapter discusses the relationship of alcohol and fatty acid ethyl esters. Fatty Acid Ethyl Esters (FAEE) are nonoxidative ethanol metabolites that are esterification products of fatty acids and ethanol. FAEE directly contribute to cell injury induced by ethanol abuse, but the exact mechanism by which FAEE mediate this toxic effect remains to be discovered. Most of the enzyme activities found to be catalytic for FAEE synthesis are esterification enzymes that link fatty acid or fatty acyl-CoA to ethanol. However, there are a number of reports that suggest that the hydrolysis of fatty acids from a more complex lipid molecule (such as phospholipid and triglyceride) is the rate limiting step in the formation of FAEE, and that the esterification step is presumably either nonrate-limiting or nonenzymatic. FAEE are of growing importance in the toxicity induced by excess ethanol intake. There is an increasing evidence that FAEE mediated cytotoxicity and FAEE are proving to be a robust marker of ethanol intake in a variety of cells and tissues, and in the blood. The use of FAEE to monitor ethanol intake or to identify individuals as chronic alcoholics should continue to strengthen as more clinical studies are completed.

Original languageEnglish (US)
Title of host publicationComprehensive Handbook of Alcohol Related Pathology
PublisherElsevier Inc.
Pages1195-1207
Number of pages13
Volume3-3
ISBN (Print)9780080502311, 9780125643702
DOIs
StatePublished - Dec 30 2004
Externally publishedYes

Fingerprint

Esters
Alcohols
Fatty Acids
Ethanol
Esterification
Acyl Coenzyme A
Poisons
Enzyme activity
Enzymes
Alcoholics
Cytotoxicity
Metabolites
Toxicity
Hydrolysis
Phospholipids
Triglycerides
Blood
Tissue
Lipids
Molecules

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Salem, R. O., & Laposata, M. (2004). Alcohol and Fatty Acid Ethyl Esters. In Comprehensive Handbook of Alcohol Related Pathology (Vol. 3-3, pp. 1195-1207). Elsevier Inc.. https://doi.org/10.1016/B978-012564370-2/50093-3

Alcohol and Fatty Acid Ethyl Esters. / Salem, Raneem O.; Laposata, Michael.

Comprehensive Handbook of Alcohol Related Pathology. Vol. 3-3 Elsevier Inc., 2004. p. 1195-1207.

Research output: Chapter in Book/Report/Conference proceedingChapter

Salem, RO & Laposata, M 2004, Alcohol and Fatty Acid Ethyl Esters. in Comprehensive Handbook of Alcohol Related Pathology. vol. 3-3, Elsevier Inc., pp. 1195-1207. https://doi.org/10.1016/B978-012564370-2/50093-3
Salem RO, Laposata M. Alcohol and Fatty Acid Ethyl Esters. In Comprehensive Handbook of Alcohol Related Pathology. Vol. 3-3. Elsevier Inc. 2004. p. 1195-1207 https://doi.org/10.1016/B978-012564370-2/50093-3
Salem, Raneem O. ; Laposata, Michael. / Alcohol and Fatty Acid Ethyl Esters. Comprehensive Handbook of Alcohol Related Pathology. Vol. 3-3 Elsevier Inc., 2004. pp. 1195-1207
@inbook{3f3dc01427824c9685e6afe508987eba,
title = "Alcohol and Fatty Acid Ethyl Esters",
abstract = "This chapter discusses the relationship of alcohol and fatty acid ethyl esters. Fatty Acid Ethyl Esters (FAEE) are nonoxidative ethanol metabolites that are esterification products of fatty acids and ethanol. FAEE directly contribute to cell injury induced by ethanol abuse, but the exact mechanism by which FAEE mediate this toxic effect remains to be discovered. Most of the enzyme activities found to be catalytic for FAEE synthesis are esterification enzymes that link fatty acid or fatty acyl-CoA to ethanol. However, there are a number of reports that suggest that the hydrolysis of fatty acids from a more complex lipid molecule (such as phospholipid and triglyceride) is the rate limiting step in the formation of FAEE, and that the esterification step is presumably either nonrate-limiting or nonenzymatic. FAEE are of growing importance in the toxicity induced by excess ethanol intake. There is an increasing evidence that FAEE mediated cytotoxicity and FAEE are proving to be a robust marker of ethanol intake in a variety of cells and tissues, and in the blood. The use of FAEE to monitor ethanol intake or to identify individuals as chronic alcoholics should continue to strengthen as more clinical studies are completed.",
author = "Salem, {Raneem O.} and Michael Laposata",
year = "2004",
month = "12",
day = "30",
doi = "10.1016/B978-012564370-2/50093-3",
language = "English (US)",
isbn = "9780080502311",
volume = "3-3",
pages = "1195--1207",
booktitle = "Comprehensive Handbook of Alcohol Related Pathology",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Alcohol and Fatty Acid Ethyl Esters

AU - Salem, Raneem O.

AU - Laposata, Michael

PY - 2004/12/30

Y1 - 2004/12/30

N2 - This chapter discusses the relationship of alcohol and fatty acid ethyl esters. Fatty Acid Ethyl Esters (FAEE) are nonoxidative ethanol metabolites that are esterification products of fatty acids and ethanol. FAEE directly contribute to cell injury induced by ethanol abuse, but the exact mechanism by which FAEE mediate this toxic effect remains to be discovered. Most of the enzyme activities found to be catalytic for FAEE synthesis are esterification enzymes that link fatty acid or fatty acyl-CoA to ethanol. However, there are a number of reports that suggest that the hydrolysis of fatty acids from a more complex lipid molecule (such as phospholipid and triglyceride) is the rate limiting step in the formation of FAEE, and that the esterification step is presumably either nonrate-limiting or nonenzymatic. FAEE are of growing importance in the toxicity induced by excess ethanol intake. There is an increasing evidence that FAEE mediated cytotoxicity and FAEE are proving to be a robust marker of ethanol intake in a variety of cells and tissues, and in the blood. The use of FAEE to monitor ethanol intake or to identify individuals as chronic alcoholics should continue to strengthen as more clinical studies are completed.

AB - This chapter discusses the relationship of alcohol and fatty acid ethyl esters. Fatty Acid Ethyl Esters (FAEE) are nonoxidative ethanol metabolites that are esterification products of fatty acids and ethanol. FAEE directly contribute to cell injury induced by ethanol abuse, but the exact mechanism by which FAEE mediate this toxic effect remains to be discovered. Most of the enzyme activities found to be catalytic for FAEE synthesis are esterification enzymes that link fatty acid or fatty acyl-CoA to ethanol. However, there are a number of reports that suggest that the hydrolysis of fatty acids from a more complex lipid molecule (such as phospholipid and triglyceride) is the rate limiting step in the formation of FAEE, and that the esterification step is presumably either nonrate-limiting or nonenzymatic. FAEE are of growing importance in the toxicity induced by excess ethanol intake. There is an increasing evidence that FAEE mediated cytotoxicity and FAEE are proving to be a robust marker of ethanol intake in a variety of cells and tissues, and in the blood. The use of FAEE to monitor ethanol intake or to identify individuals as chronic alcoholics should continue to strengthen as more clinical studies are completed.

UR - http://www.scopus.com/inward/record.url?scp=84943235234&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943235234&partnerID=8YFLogxK

U2 - 10.1016/B978-012564370-2/50093-3

DO - 10.1016/B978-012564370-2/50093-3

M3 - Chapter

SN - 9780080502311

SN - 9780125643702

VL - 3-3

SP - 1195

EP - 1207

BT - Comprehensive Handbook of Alcohol Related Pathology

PB - Elsevier Inc.

ER -