Abstract
Background and objective. Steatohepatitis is a common cause of liver disease due to alcohol (ALD) or non-alcoholic fatty liver disease (NAFLD). We performed this study to compare natural history of ALD and NAFLD. Material and methods. Retrospective analysis of ALD or NAFLD patients managed at our center (2007-2011). ALD diagnosed by excluding other liver diseases (except HCV) and alcohol abuse of > 40 g/d in women and > 60 g/d in men for > 5 years. NAFLD diagnosed by excluding other liver diseases and a history of alcohol use of <10 g/d. Cirrhosis was diagnosed using biopsy for uncertain clinical diagnosis. Results. Compared to patients with NAFLD (n = 365; mean age 50 yrs; 43% males; 53% diabetic), ALD patients (n = 206; mean age 51 yrs; 68% males; 24% diabetic) presented more often with cirrhosis or complications(46vs. 12%; P<0.0001) with a higher MELD score (13 ±7 vs. 8 ± 8; P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 183-189 |
| Number of pages | 7 |
| Journal | Annals of Hepatology |
| Volume | 15 |
| Issue number | 2 |
| State | Published - Mar 1 2016 |
Fingerprint
Keywords
- Cirrhosis
- HCC
- NAFLD
- Steatohepatitis
ASJC Scopus subject areas
- Hepatology
Cite this
Alcoholic liver disease presents at advanced stage and progresses faster compared to non-alcoholic fatty liver disease. / Shoreibah, Mohamed; Raff, Evan; Bloomer, Joseph; Kakati, Donny; Rasheed, Khalid; Kuo, Yong Fang; Singal, Ashwani K.
In: Annals of Hepatology, Vol. 15, No. 2, 01.03.2016, p. 183-189.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alcoholic liver disease presents at advanced stage and progresses faster compared to non-alcoholic fatty liver disease
AU - Shoreibah, Mohamed
AU - Raff, Evan
AU - Bloomer, Joseph
AU - Kakati, Donny
AU - Rasheed, Khalid
AU - Kuo, Yong Fang
AU - Singal, Ashwani K.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Background and objective. Steatohepatitis is a common cause of liver disease due to alcohol (ALD) or non-alcoholic fatty liver disease (NAFLD). We performed this study to compare natural history of ALD and NAFLD. Material and methods. Retrospective analysis of ALD or NAFLD patients managed at our center (2007-2011). ALD diagnosed by excluding other liver diseases (except HCV) and alcohol abuse of > 40 g/d in women and > 60 g/d in men for > 5 years. NAFLD diagnosed by excluding other liver diseases and a history of alcohol use of <10 g/d. Cirrhosis was diagnosed using biopsy for uncertain clinical diagnosis. Results. Compared to patients with NAFLD (n = 365; mean age 50 yrs; 43% males; 53% diabetic), ALD patients (n = 206; mean age 51 yrs; 68% males; 24% diabetic) presented more often with cirrhosis or complications(46vs. 12%; P<0.0001) with a higher MELD score (13 ±7 vs. 8 ± 8; P
AB - Background and objective. Steatohepatitis is a common cause of liver disease due to alcohol (ALD) or non-alcoholic fatty liver disease (NAFLD). We performed this study to compare natural history of ALD and NAFLD. Material and methods. Retrospective analysis of ALD or NAFLD patients managed at our center (2007-2011). ALD diagnosed by excluding other liver diseases (except HCV) and alcohol abuse of > 40 g/d in women and > 60 g/d in men for > 5 years. NAFLD diagnosed by excluding other liver diseases and a history of alcohol use of <10 g/d. Cirrhosis was diagnosed using biopsy for uncertain clinical diagnosis. Results. Compared to patients with NAFLD (n = 365; mean age 50 yrs; 43% males; 53% diabetic), ALD patients (n = 206; mean age 51 yrs; 68% males; 24% diabetic) presented more often with cirrhosis or complications(46vs. 12%; P<0.0001) with a higher MELD score (13 ±7 vs. 8 ± 8; P
KW - Cirrhosis
KW - HCC
KW - NAFLD
KW - Steatohepatitis
UR - http://www.scopus.com/inward/record.url?scp=84957044741&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957044741&partnerID=8YFLogxK
M3 - Article
VL - 15
SP - 183
EP - 189
JO - Annals of Hepatology
JF - Annals of Hepatology
SN - 1665-2681
IS - 2
ER -