Alcoholic liver disease presents at advanced stage and progresses faster compared to non-alcoholic fatty liver disease

Mohamed Shoreibah, Evan Raff, Joseph Bloomer, Donny Kakati, Khalid Rasheed, Yong Fang Kuo, Ashwani K. Singal

    Research output: Contribution to journalArticlepeer-review

    16 Scopus citations

    Abstract

    Background and objective. Steatohepatitis is a common cause of liver disease due to alcohol (ALD) or non-alcoholic fatty liver disease (NAFLD). We performed this study to compare natural history of ALD and NAFLD. Material and methods. Retrospective analysis of ALD or NAFLD patients managed at our center (2007-2011). ALD diagnosed by excluding other liver diseases (except HCV) and alcohol abuse of > 40 g/d in women and > 60 g/d in men for > 5 years. NAFLD diagnosed by excluding other liver diseases and a history of alcohol use of <10 g/d. Cirrhosis was diagnosed using biopsy for uncertain clinical diagnosis. Results. Compared to patients with NAFLD (n = 365; mean age 50 yrs; 43% males; 53% diabetic), ALD patients (n = 206; mean age 51 yrs; 68% males; 24% diabetic) presented more often with cirrhosis or complications(46vs. 12%; P<0.0001) with a higher MELD score (13 ±7 vs. 8 ± 8; P

    Original languageEnglish (US)
    Pages (from-to)183-189
    Number of pages7
    JournalAnnals of Hepatology
    Volume15
    Issue number2
    StatePublished - Mar 1 2016

    Keywords

    • Cirrhosis
    • HCC
    • NAFLD
    • Steatohepatitis

    ASJC Scopus subject areas

    • Hepatology

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