Alcoholic liver disease presents at advanced stage and progresses faster compared to non-alcoholic fatty liver disease

Mohamed Shoreibah; Evan Raff; Joseph Bloomer; Donny Kakati; Khalid Rasheed; Yong Fang Kuo; Ashwani K. Singal

Alcoholic liver disease presents at advanced stage and progresses faster compared to non-alcoholic fatty liver disease

Mohamed Shoreibah, Evan Raff, Joseph Bloomer, Donny Kakati, Khalid Rasheed, Yong Fang Kuo, Ashwani K. Singal

Preventive Medicine & Community Health

Research output: Contribution to journal › Article

5 Scopus citations

Abstract

Background and objective. Steatohepatitis is a common cause of liver disease due to alcohol (ALD) or non-alcoholic fatty liver disease (NAFLD). We performed this study to compare natural history of ALD and NAFLD. Material and methods. Retrospective analysis of ALD or NAFLD patients managed at our center (2007-2011). ALD diagnosed by excluding other liver diseases (except HCV) and alcohol abuse of > 40 g/d in women and > 60 g/d in men for > 5 years. NAFLD diagnosed by excluding other liver diseases and a history of alcohol use of <10 g/d. Cirrhosis was diagnosed using biopsy for uncertain clinical diagnosis. Results. Compared to patients with NAFLD (n = 365; mean age 50 yrs; 43% males; 53% diabetic), ALD patients (n = 206; mean age 51 yrs; 68% males; 24% diabetic) presented more often with cirrhosis or complications(46vs. 12%; P<0.0001) with a higher MELD score (13 ±7 vs. 8 ± 8; P

Original language	English (US)
Pages (from-to)	183-189
Number of pages	7
Journal	Annals of Hepatology
Volume	15
Issue number	2
State	Published - Mar 1 2016

Keywords

Cirrhosis
HCC
NAFLD
Steatohepatitis

ASJC Scopus subject areas

Hepatology

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Shoreibah, M., Raff, E., Bloomer, J., Kakati, D., Rasheed, K., Kuo, Y. F., & Singal, A. K. (2016). Alcoholic liver disease presents at advanced stage and progresses faster compared to non-alcoholic fatty liver disease. Annals of Hepatology, 15(2), 183-189.

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abstract = "Background and objective. Steatohepatitis is a common cause of liver disease due to alcohol (ALD) or non-alcoholic fatty liver disease (NAFLD). We performed this study to compare natural history of ALD and NAFLD. Material and methods. Retrospective analysis of ALD or NAFLD patients managed at our center (2007-2011). ALD diagnosed by excluding other liver diseases (except HCV) and alcohol abuse of > 40 g/d in women and > 60 g/d in men for > 5 years. NAFLD diagnosed by excluding other liver diseases and a history of alcohol use of <10 g/d. Cirrhosis was diagnosed using biopsy for uncertain clinical diagnosis. Results. Compared to patients with NAFLD (n = 365; mean age 50 yrs; 43% males; 53% diabetic), ALD patients (n = 206; mean age 51 yrs; 68% males; 24% diabetic) presented more often with cirrhosis or complications(46vs. 12%; P<0.0001) with a higher MELD score (13 ±7 vs. 8 ± 8; P",

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author = "Mohamed Shoreibah and Evan Raff and Joseph Bloomer and Donny Kakati and Khalid Rasheed and Kuo, {Yong Fang} and Singal, {Ashwani K.}",

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T1 - Alcoholic liver disease presents at advanced stage and progresses faster compared to non-alcoholic fatty liver disease

AU - Shoreibah, Mohamed

AU - Raff, Evan

AU - Bloomer, Joseph

AU - Kakati, Donny

AU - Rasheed, Khalid

AU - Kuo, Yong Fang

AU - Singal, Ashwani K.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Background and objective. Steatohepatitis is a common cause of liver disease due to alcohol (ALD) or non-alcoholic fatty liver disease (NAFLD). We performed this study to compare natural history of ALD and NAFLD. Material and methods. Retrospective analysis of ALD or NAFLD patients managed at our center (2007-2011). ALD diagnosed by excluding other liver diseases (except HCV) and alcohol abuse of > 40 g/d in women and > 60 g/d in men for > 5 years. NAFLD diagnosed by excluding other liver diseases and a history of alcohol use of <10 g/d. Cirrhosis was diagnosed using biopsy for uncertain clinical diagnosis. Results. Compared to patients with NAFLD (n = 365; mean age 50 yrs; 43% males; 53% diabetic), ALD patients (n = 206; mean age 51 yrs; 68% males; 24% diabetic) presented more often with cirrhosis or complications(46vs. 12%; P<0.0001) with a higher MELD score (13 ±7 vs. 8 ± 8; P

AB - Background and objective. Steatohepatitis is a common cause of liver disease due to alcohol (ALD) or non-alcoholic fatty liver disease (NAFLD). We performed this study to compare natural history of ALD and NAFLD. Material and methods. Retrospective analysis of ALD or NAFLD patients managed at our center (2007-2011). ALD diagnosed by excluding other liver diseases (except HCV) and alcohol abuse of > 40 g/d in women and > 60 g/d in men for > 5 years. NAFLD diagnosed by excluding other liver diseases and a history of alcohol use of <10 g/d. Cirrhosis was diagnosed using biopsy for uncertain clinical diagnosis. Results. Compared to patients with NAFLD (n = 365; mean age 50 yrs; 43% males; 53% diabetic), ALD patients (n = 206; mean age 51 yrs; 68% males; 24% diabetic) presented more often with cirrhosis or complications(46vs. 12%; P<0.0001) with a higher MELD score (13 ±7 vs. 8 ± 8; P

KW - Cirrhosis

KW - HCC

KW - NAFLD

KW - Steatohepatitis

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