Aldose reductase: A novel therapeutic target for inflammatory pathologies

Kota Ramana, Satish Srivastava

Research output: Contribution to journalArticle

108 Scopus citations

Abstract

Aldose reductase (AR), that catalyzes the rate limiting step of the polyol pathway of glucose metabolism, besides reducing glucose to sorbitol, reduces a number of lipid peroxidation - derived aldehydes and their glutathione conjugates. Recent studies suggest that apart from its involvement in diabetic complications, AR's catalytic activity plays a key role in a number of inflammatory diseases such as atherosclerosis, sepsis, asthma, uveitis, and colon cancer. Furthermore, AR is overexpressed in human cancers such as liver, colon, breast, cervical and ovarian. Since AR inhibitors have already undergone up to phase-iii clinical trials for diabetic complications, they could be safe anti-inflammatory drugs. Therefore the future use of AR inhibitors in down-regulating major inflammatory pathologies such as cancer and cardiovascular diseases could relieve some of the major health concerns of worldwide.

Original languageEnglish (US)
Pages (from-to)17-20
Number of pages4
JournalInternational Journal of Biochemistry and Cell Biology
Volume42
Issue number1
DOIs
StatePublished - Jan 2010

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Keywords

  • Aldehydes
  • Aldose reductase
  • Inflammation
  • NF-κB
  • Oxidative stress

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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