TY - JOUR
T1 - Aldose reductase
T2 - A novel therapeutic target for inflammatory pathologies
AU - Ramana, Kota V.
AU - Srivastava, Satish K.
N1 - Funding Information:
This work was supported in parts by National Institute of Health grants DK36118 and CA129383 (S.K.S), and GM 71036 and EY 018591 (K.V.R).
PY - 2010/1
Y1 - 2010/1
N2 - Aldose reductase (AR), that catalyzes the rate limiting step of the polyol pathway of glucose metabolism, besides reducing glucose to sorbitol, reduces a number of lipid peroxidation - derived aldehydes and their glutathione conjugates. Recent studies suggest that apart from its involvement in diabetic complications, AR's catalytic activity plays a key role in a number of inflammatory diseases such as atherosclerosis, sepsis, asthma, uveitis, and colon cancer. Furthermore, AR is overexpressed in human cancers such as liver, colon, breast, cervical and ovarian. Since AR inhibitors have already undergone up to phase-iii clinical trials for diabetic complications, they could be safe anti-inflammatory drugs. Therefore the future use of AR inhibitors in down-regulating major inflammatory pathologies such as cancer and cardiovascular diseases could relieve some of the major health concerns of worldwide.
AB - Aldose reductase (AR), that catalyzes the rate limiting step of the polyol pathway of glucose metabolism, besides reducing glucose to sorbitol, reduces a number of lipid peroxidation - derived aldehydes and their glutathione conjugates. Recent studies suggest that apart from its involvement in diabetic complications, AR's catalytic activity plays a key role in a number of inflammatory diseases such as atherosclerosis, sepsis, asthma, uveitis, and colon cancer. Furthermore, AR is overexpressed in human cancers such as liver, colon, breast, cervical and ovarian. Since AR inhibitors have already undergone up to phase-iii clinical trials for diabetic complications, they could be safe anti-inflammatory drugs. Therefore the future use of AR inhibitors in down-regulating major inflammatory pathologies such as cancer and cardiovascular diseases could relieve some of the major health concerns of worldwide.
KW - Aldehydes
KW - Aldose reductase
KW - Inflammation
KW - NF-κB
KW - Oxidative stress
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U2 - 10.1016/j.biocel.2009.09.009
DO - 10.1016/j.biocel.2009.09.009
M3 - Short survey
C2 - 19778627
AN - SCOPUS:70749089191
SN - 1357-2725
VL - 42
SP - 17
EP - 20
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
IS - 1
ER -