Aldose reductase mediates NLRP3 inflammasome-initiated innate immune response in hyperglycemia-induced thp1 monocytes and male mice

Keyphrases

• Hyperglycemia 100%
• Innate Immune Response 100%
• Monocytes 100%
• Aldose Reductase 100%
• Male Mice 100%
• NOD-like Receptor Protein 3 (NLRP3) 100%
• Reactive Oxygen Species 42%
• Oxidative Stress 28%
• Ca2+ 28%
• Phosphoinositide 3-kinase (PI3K) 28%
• Aldose Reductase Inhibitor 28%
• High Glucose 28%
• Streptozotocin-induced Diabetic Rats 28%
• Lipid Aldehydes 14%
• Efflux 14%
• Ablation 14%
• Induced Activation 14%
• Interleukin-1β 14%
• Reactive Oxygen Species Production 14%
• Stress-induced 14%
• Diabetes Complications 14%
• Inflammatory Pathways 14%
• Glutathione Conjugates 14%
• Interleukin-18 (IL-18) 14%
• Fidarestat 14%
• Caspase-1 14%
• Mouse Heart 14%
• Mouse Aorta 14%
• Immune Cytokines 14%
• NLRP Inflammasome 14%

Biochemistry, Genetics and Molecular Biology

• Mouse 100%
• Monocyte 100%
• Innate Immunity 100%
• Hyperglycemia 100%
• Aldose Reductase 100%
• Inflammasome 100%
• NOD-like Receptor 100%
• Pyrin Domain 100%
• Cytokine 42%
• Oxidative Stress 28%
• Streptozotocin 28%
• Syk 28%
• Conjugate 14%
• Lipid 14%
• Aldose Reductase Inhibitor 14%
• Glutathione 14%
• Caspase 1 14%
• Interleukin 14%
• Interleukin 18 14%

Immunology and Microbiology

• Innate Immune System 100%
• Mouse 100%
• Monocyte 100%
• Inflammasome 100%
• NOD-like Receptor 100%
• Pyrin Domain 100%
• Cytokine 50%
• Oxidative Stress 33%
• Interleukin 18 16%
• Conjugate 16%
• Caspase 1 16%
• Interleukin 16%