Aldosterone synthase gene regulation by angiotensin

O. Bryan Holland, Boyd Carr, Allan R. Brasier

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Excessive aldosterone secretion in some hypertensive patients may result from abnormal aldosterone synthase (AS) gene regulation in response to changes in dietary sodium intake. We have utilized NCI-H295 cells, which exhibit stable angiotensin-induced aldosterone secretion, for transient transfections with murine AS/human growth hormone reporter constructs. An angiotensin response element increasing AS gene transcription during angiotensin stimulation appears to reside within the initial 425 nt of the murine AS promoter. We also noted the possible presence of a negatively-acting cis element between nt -425 and -1500. These studies provide an initial step toward characterizing molecular mechanisms by which angiotensin regulates AS gene transcription.

Original languageEnglish (US)
Pages (from-to)455-462
Number of pages8
JournalEndocrine Research
Volume21
Issue number1-2
DOIs
StatePublished - 1995

Fingerprint

Cytochrome P-450 CYP11B2
Angiotensins
Genes
Aldosterone
Dietary Sodium
Human Growth Hormone
Response Elements
Transfection

ASJC Scopus subject areas

  • Endocrinology

Cite this

Aldosterone synthase gene regulation by angiotensin. / Holland, O. Bryan; Carr, Boyd; Brasier, Allan R.

In: Endocrine Research, Vol. 21, No. 1-2, 1995, p. 455-462.

Research output: Contribution to journalArticle

Holland, OB, Carr, B & Brasier, AR 1995, 'Aldosterone synthase gene regulation by angiotensin', Endocrine Research, vol. 21, no. 1-2, pp. 455-462. https://doi.org/10.3109/07435809509030462
Holland, O. Bryan ; Carr, Boyd ; Brasier, Allan R. / Aldosterone synthase gene regulation by angiotensin. In: Endocrine Research. 1995 ; Vol. 21, No. 1-2. pp. 455-462.
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