Alkaline phosphatase and percentage body fat predict circulating C-reactive protein in premenopausal women

Fatima Nayeem, Karl E. Anderson, Manubai Nagamani, James J. Grady, Lee Jane W. Lu

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

C-reactive protein (CRP) is considered a marker of inflammation, which is a risk factor for many chronic diseases. However, determinants of CRP remain unclear and were studied in a strictly defined cohort of healthy premenopausal women (n=233) using multiple regression models. Independent predictors of serum CRP (model R2=0.59) were percentage body fat, serum alkaline phosphatase (ALP), sex hormone-binding globulin and white blood cell count. The close association between CRP and ALP suggests that enzymatic activity of ALP may be important for the anti-inflammatory effects of CRP, which should be confirmed with additional studies.

Original languageEnglish (US)
Pages (from-to)663-670
Number of pages8
JournalBiomarkers
Volume15
Issue number8
DOIs
StatePublished - Dec 1 2010

Keywords

  • Insulin
  • Liver enzymes
  • Obesity
  • SHBG
  • White blood cells

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

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