Alkaline phosphatase and percentage body fat predict circulating C-reactive protein in premenopausal women

Fatima Nayeem, Karl Anderson, Manubai Nagamani, James J. Grady, Leejane Lu

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

C-reactive protein (CRP) is considered a marker of inflammation, which is a risk factor for many chronic diseases. However, determinants of CRP remain unclear and were studied in a strictly defined cohort of healthy premenopausal women (n=233) using multiple regression models. Independent predictors of serum CRP (model R2=0.59) were percentage body fat, serum alkaline phosphatase (ALP), sex hormone-binding globulin and white blood cell count. The close association between CRP and ALP suggests that enzymatic activity of ALP may be important for the anti-inflammatory effects of CRP, which should be confirmed with additional studies.

Original languageEnglish (US)
Pages (from-to)663-670
Number of pages8
JournalBiomarkers
Volume15
Issue number8
DOIs
StatePublished - Dec 2010

Fingerprint

C-Reactive Protein
Alkaline Phosphatase
Adipose Tissue
Fats
Sex Hormone-Binding Globulin
Phosphoprotein Phosphatases
Leukocyte Count
Blood Proteins
Blood
Chronic Disease
Anti-Inflammatory Agents
Cells
Inflammation
Serum

Keywords

  • Insulin
  • Liver enzymes
  • Obesity
  • SHBG
  • White blood cells

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

Cite this

Alkaline phosphatase and percentage body fat predict circulating C-reactive protein in premenopausal women. / Nayeem, Fatima; Anderson, Karl; Nagamani, Manubai; Grady, James J.; Lu, Leejane.

In: Biomarkers, Vol. 15, No. 8, 12.2010, p. 663-670.

Research output: Contribution to journalArticle

Nayeem, Fatima ; Anderson, Karl ; Nagamani, Manubai ; Grady, James J. ; Lu, Leejane. / Alkaline phosphatase and percentage body fat predict circulating C-reactive protein in premenopausal women. In: Biomarkers. 2010 ; Vol. 15, No. 8. pp. 663-670.
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