Alkaline phosphatase and percentage body fat predict circulating C-reactive protein in premenopausal women

Fatima Nayeem; Karl E. Anderson; Manubai Nagamani; James J. Grady; Lee Jane W. Lu

doi:10.3109/1354750X.2010.509811

Alkaline phosphatase and percentage body fat predict circulating C-reactive protein in premenopausal women

Fatima Nayeem
, Karl E. Anderson
, Manubai Nagamani
, James J. Grady
, Lee Jane W. Lu

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

C-reactive protein (CRP) is considered a marker of inflammation, which is a risk factor for many chronic diseases. However, determinants of CRP remain unclear and were studied in a strictly defined cohort of healthy premenopausal women (n=233) using multiple regression models. Independent predictors of serum CRP (model R²=0.59) were percentage body fat, serum alkaline phosphatase (ALP), sex hormone-binding globulin and white blood cell count. The close association between CRP and ALP suggests that enzymatic activity of ALP may be important for the anti-inflammatory effects of CRP, which should be confirmed with additional studies.

Original language	English (US)
Pages (from-to)	663-670
Number of pages	8
Journal	Biomarkers
Volume	15
Issue number	8
DOIs	https://doi.org/10.3109/1354750X.2010.509811
State	Published - Dec 2010

Keywords

Insulin
Liver enzymes
Obesity
SHBG
White blood cells

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

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10.3109/1354750X.2010.509811

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title = "Alkaline phosphatase and percentage body fat predict circulating C-reactive protein in premenopausal women",

abstract = "C-reactive protein (CRP) is considered a marker of inflammation, which is a risk factor for many chronic diseases. However, determinants of CRP remain unclear and were studied in a strictly defined cohort of healthy premenopausal women (n=233) using multiple regression models. Independent predictors of serum CRP (model R2=0.59) were percentage body fat, serum alkaline phosphatase (ALP), sex hormone-binding globulin and white blood cell count. The close association between CRP and ALP suggests that enzymatic activity of ALP may be important for the anti-inflammatory effects of CRP, which should be confirmed with additional studies.",

keywords = "Insulin, Liver enzymes, Obesity, SHBG, White blood cells",

author = "Fatima Nayeem and Anderson, \{Karl E.\} and Manubai Nagamani and Grady, \{James J.\} and Lu, \{Lee Jane W.\}",

note = "Funding Information: The research was supported by US Army Medical Research and Materiel Command DADM17-01-1-0417 (the content of the information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred; the US Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick, MD 21702-5014 is the awarding and administering acquisition office), and National Institute of Health (NIH) Grants National Center for Research Resources M01-RR-00073 and 1UL1RR029876-01, National Cancer Institute CA95545, CA65628, and National Institute of Environmental Health Sciences ES006676. The study is registered at www.clinicaltrials.gov and the identifier is NCT00204477 and the clinical trial registration date is September 9, 2005. The authors have nothing to disclose.",

year = "2010",

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doi = "10.3109/1354750X.2010.509811",

language = "English (US)",

volume = "15",

pages = "663--670",

journal = "Biomarkers",

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TY - JOUR

T1 - Alkaline phosphatase and percentage body fat predict circulating C-reactive protein in premenopausal women

AU - Nayeem, Fatima

AU - Anderson, Karl E.

AU - Nagamani, Manubai

AU - Grady, James J.

AU - Lu, Lee Jane W.

N1 - Funding Information: The research was supported by US Army Medical Research and Materiel Command DADM17-01-1-0417 (the content of the information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred; the US Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick, MD 21702-5014 is the awarding and administering acquisition office), and National Institute of Health (NIH) Grants National Center for Research Resources M01-RR-00073 and 1UL1RR029876-01, National Cancer Institute CA95545, CA65628, and National Institute of Environmental Health Sciences ES006676. The study is registered at www.clinicaltrials.gov and the identifier is NCT00204477 and the clinical trial registration date is September 9, 2005. The authors have nothing to disclose.

PY - 2010/12

Y1 - 2010/12

N2 - C-reactive protein (CRP) is considered a marker of inflammation, which is a risk factor for many chronic diseases. However, determinants of CRP remain unclear and were studied in a strictly defined cohort of healthy premenopausal women (n=233) using multiple regression models. Independent predictors of serum CRP (model R2=0.59) were percentage body fat, serum alkaline phosphatase (ALP), sex hormone-binding globulin and white blood cell count. The close association between CRP and ALP suggests that enzymatic activity of ALP may be important for the anti-inflammatory effects of CRP, which should be confirmed with additional studies.

AB - C-reactive protein (CRP) is considered a marker of inflammation, which is a risk factor for many chronic diseases. However, determinants of CRP remain unclear and were studied in a strictly defined cohort of healthy premenopausal women (n=233) using multiple regression models. Independent predictors of serum CRP (model R2=0.59) were percentage body fat, serum alkaline phosphatase (ALP), sex hormone-binding globulin and white blood cell count. The close association between CRP and ALP suggests that enzymatic activity of ALP may be important for the anti-inflammatory effects of CRP, which should be confirmed with additional studies.

KW - Insulin

KW - Liver enzymes

KW - Obesity

KW - SHBG

KW - White blood cells

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SN - 1354-750X

VL - 15

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JO - Biomarkers

JF - Biomarkers

IS - 8

ER -

Alkaline phosphatase and percentage body fat predict circulating C-reactive protein in premenopausal women

Abstract

Keywords

ASJC Scopus subject areas

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