Alkylation mutagenesis in Saccharomyces cerevisiae: lack of evidence for an adaptive response

Renata Polakowska, Giuditta Perozzi, Louise Prakash

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

We have found no evidence for an adaptive response for either lethality or mutagenesis following treatment of Saccharomyces cerevisiae with N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). The rad6 and rad52 mutants of S. cerevisiae are highly defective in MNNG and ethyl methanesulfonate induced mutagenesis of both stationary and exponential phase cells. These and other observations indicate that the mechanisms of repair of alkylation damage and mutagenesis differ markedly between S. cerevisiae and Escherichia coli.

Original languageEnglish (US)
Pages (from-to)647-655
Number of pages9
JournalCurrent Genetics
Volume10
Issue number9
DOIs
StatePublished - May 1 1986
Externally publishedYes

Keywords

  • Adaptive response
  • Alkylation mutagenesis
  • Yeast
  • rad52
  • rad6

ASJC Scopus subject areas

  • Genetics

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