All-trans-Retmoic Acid Inhibits Growth of Human Pancreatic Cancer Cell Lines

Richard J. Bold, Jin Ishizuka, Courtney Townsend, James C. Thompson

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Retinoids are a class of molecules structurally related to vitamin A that have potent antiproliferative and differentiating effects on a variety of normal and neoplastic tissues. All-frans-retinoic acid (ATRA) has become a first-line chemotherapeutic agent in the treatment of certain leukemias; however, the effect of ATRA on pancreatic tumors is unknown. The purpose of this study was to determine the effect of ATRA on the growth characteristics of both exocrine and endocrine human pancreatic cancer cell lines. The in vitro growth of four cell lines was examined after treatment with a wide dose range of ATRA. The growth of all tumor cell lines was inhibited by ATRA in a dose-dependent fashion beginning at 0.1 μM. The in vivo growth of functioning human pancreatic carcinoid (BON) xenografts in Balb/c athymic mice was determined by treatment with several doses of ATRA over 1 month. The growth of BON tumors was inhibited in a dose-dependent fashion. These results suggest that ATRA exerts direct antiproliferative effects on both exocrine and endocrine human pancreatic cancers and may be useful in the chemotherapy of these tumors.

Original languageEnglish (US)
Pages (from-to)189-195
Number of pages7
JournalPancreas
Volume12
Issue number2
StatePublished - 1996

Fingerprint

Pancreatic Neoplasms
Cell Line
Acids
Growth
Neoplasms
Retinoids
Carcinoid Tumor
Tretinoin
Tumor Cell Line
Vitamin A
Heterografts
Nude Mice
Leukemia
Therapeutics
Drug Therapy

Keywords

  • All-trans-retinoic acid
  • Growth inhibition
  • Pancreatic tumor

ASJC Scopus subject areas

  • Endocrinology
  • Gastroenterology

Cite this

Bold, R. J., Ishizuka, J., Townsend, C., & Thompson, J. C. (1996). All-trans-Retmoic Acid Inhibits Growth of Human Pancreatic Cancer Cell Lines. Pancreas, 12(2), 189-195.

All-trans-Retmoic Acid Inhibits Growth of Human Pancreatic Cancer Cell Lines. / Bold, Richard J.; Ishizuka, Jin; Townsend, Courtney; Thompson, James C.

In: Pancreas, Vol. 12, No. 2, 1996, p. 189-195.

Research output: Contribution to journalArticle

Bold, RJ, Ishizuka, J, Townsend, C & Thompson, JC 1996, 'All-trans-Retmoic Acid Inhibits Growth of Human Pancreatic Cancer Cell Lines', Pancreas, vol. 12, no. 2, pp. 189-195.
Bold, Richard J. ; Ishizuka, Jin ; Townsend, Courtney ; Thompson, James C. / All-trans-Retmoic Acid Inhibits Growth of Human Pancreatic Cancer Cell Lines. In: Pancreas. 1996 ; Vol. 12, No. 2. pp. 189-195.
@article{fa2abf97614e430d93ea371154137ece,
title = "All-trans-Retmoic Acid Inhibits Growth of Human Pancreatic Cancer Cell Lines",
abstract = "Retinoids are a class of molecules structurally related to vitamin A that have potent antiproliferative and differentiating effects on a variety of normal and neoplastic tissues. All-frans-retinoic acid (ATRA) has become a first-line chemotherapeutic agent in the treatment of certain leukemias; however, the effect of ATRA on pancreatic tumors is unknown. The purpose of this study was to determine the effect of ATRA on the growth characteristics of both exocrine and endocrine human pancreatic cancer cell lines. The in vitro growth of four cell lines was examined after treatment with a wide dose range of ATRA. The growth of all tumor cell lines was inhibited by ATRA in a dose-dependent fashion beginning at 0.1 μM. The in vivo growth of functioning human pancreatic carcinoid (BON) xenografts in Balb/c athymic mice was determined by treatment with several doses of ATRA over 1 month. The growth of BON tumors was inhibited in a dose-dependent fashion. These results suggest that ATRA exerts direct antiproliferative effects on both exocrine and endocrine human pancreatic cancers and may be useful in the chemotherapy of these tumors.",
keywords = "All-trans-retinoic acid, Growth inhibition, Pancreatic tumor",
author = "Bold, {Richard J.} and Jin Ishizuka and Courtney Townsend and Thompson, {James C.}",
year = "1996",
language = "English (US)",
volume = "12",
pages = "189--195",
journal = "Pancreas",
issn = "0885-3177",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - All-trans-Retmoic Acid Inhibits Growth of Human Pancreatic Cancer Cell Lines

AU - Bold, Richard J.

AU - Ishizuka, Jin

AU - Townsend, Courtney

AU - Thompson, James C.

PY - 1996

Y1 - 1996

N2 - Retinoids are a class of molecules structurally related to vitamin A that have potent antiproliferative and differentiating effects on a variety of normal and neoplastic tissues. All-frans-retinoic acid (ATRA) has become a first-line chemotherapeutic agent in the treatment of certain leukemias; however, the effect of ATRA on pancreatic tumors is unknown. The purpose of this study was to determine the effect of ATRA on the growth characteristics of both exocrine and endocrine human pancreatic cancer cell lines. The in vitro growth of four cell lines was examined after treatment with a wide dose range of ATRA. The growth of all tumor cell lines was inhibited by ATRA in a dose-dependent fashion beginning at 0.1 μM. The in vivo growth of functioning human pancreatic carcinoid (BON) xenografts in Balb/c athymic mice was determined by treatment with several doses of ATRA over 1 month. The growth of BON tumors was inhibited in a dose-dependent fashion. These results suggest that ATRA exerts direct antiproliferative effects on both exocrine and endocrine human pancreatic cancers and may be useful in the chemotherapy of these tumors.

AB - Retinoids are a class of molecules structurally related to vitamin A that have potent antiproliferative and differentiating effects on a variety of normal and neoplastic tissues. All-frans-retinoic acid (ATRA) has become a first-line chemotherapeutic agent in the treatment of certain leukemias; however, the effect of ATRA on pancreatic tumors is unknown. The purpose of this study was to determine the effect of ATRA on the growth characteristics of both exocrine and endocrine human pancreatic cancer cell lines. The in vitro growth of four cell lines was examined after treatment with a wide dose range of ATRA. The growth of all tumor cell lines was inhibited by ATRA in a dose-dependent fashion beginning at 0.1 μM. The in vivo growth of functioning human pancreatic carcinoid (BON) xenografts in Balb/c athymic mice was determined by treatment with several doses of ATRA over 1 month. The growth of BON tumors was inhibited in a dose-dependent fashion. These results suggest that ATRA exerts direct antiproliferative effects on both exocrine and endocrine human pancreatic cancers and may be useful in the chemotherapy of these tumors.

KW - All-trans-retinoic acid

KW - Growth inhibition

KW - Pancreatic tumor

UR - http://www.scopus.com/inward/record.url?scp=0030071519&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030071519&partnerID=8YFLogxK

M3 - Article

VL - 12

SP - 189

EP - 195

JO - Pancreas

JF - Pancreas

SN - 0885-3177

IS - 2

ER -