Abstract
BACKGROUND: Allergic fungal sinusitis (AFS) is a newly recognized form of sinusitis characterized by opacification of the paranasal sinuses by 'allergic mucin' (AM) admixed with scattered fungal organisms. AM consists of necrotic, or partially necrotic, eosinophils and Charcot-Leyden crystals suspended in lakes of laminated, mucinous material. AFS is characterized by the absence of bone or soft tissue invasion, purulent exudate or granulomatous inflammation. Clinically, it is important to differentiate AFS from both acute invasive fungal sinusitis and noninvasive mycetoma because the three diseases are treated with different modalities and have different prognoses. Although the radiologic features of AFS are often characteristic, occasionally it may be difficult to exclude neoplasia. CASES: Two cases of AFS, in which intraoperative diagnosis was made on the basis of the presence of both AM and fungal organisms, are reported. CONCLUSION: Cytologic diagnosis of AFS can be made from intraoperative sinus aspirates from the presence of AM and fungal elements. AM and fungi provide presumptive evidence for a noninvasive, allergic fungal disease and can help reassure clinicians intraoperatively and guide clinical management.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 268-272 |
| Number of pages | 5 |
| Journal | Acta Cytologica |
| Volume | 43 |
| Issue number | 2 |
| State | Published - 1999 |
Fingerprint
Keywords
- Allergic fungal sinusitis
- Allergy
- Aspiration biopsy
- Intraoperative period
- Sinusitis
ASJC Scopus subject areas
- Anatomy
- Cell Biology
- Histology
Cite this
Allergic fungal sinusitis : A report of two cases with diagnosis by intraoperative aspiration cytology. / Schnadig, Vicki J.; Rassekh, Christopher H.; Gourley, William K.
In: Acta Cytologica, Vol. 43, No. 2, 1999, p. 268-272.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Allergic fungal sinusitis
T2 - A report of two cases with diagnosis by intraoperative aspiration cytology
AU - Schnadig, Vicki J.
AU - Rassekh, Christopher H.
AU - Gourley, William K.
PY - 1999
Y1 - 1999
N2 - BACKGROUND: Allergic fungal sinusitis (AFS) is a newly recognized form of sinusitis characterized by opacification of the paranasal sinuses by 'allergic mucin' (AM) admixed with scattered fungal organisms. AM consists of necrotic, or partially necrotic, eosinophils and Charcot-Leyden crystals suspended in lakes of laminated, mucinous material. AFS is characterized by the absence of bone or soft tissue invasion, purulent exudate or granulomatous inflammation. Clinically, it is important to differentiate AFS from both acute invasive fungal sinusitis and noninvasive mycetoma because the three diseases are treated with different modalities and have different prognoses. Although the radiologic features of AFS are often characteristic, occasionally it may be difficult to exclude neoplasia. CASES: Two cases of AFS, in which intraoperative diagnosis was made on the basis of the presence of both AM and fungal organisms, are reported. CONCLUSION: Cytologic diagnosis of AFS can be made from intraoperative sinus aspirates from the presence of AM and fungal elements. AM and fungi provide presumptive evidence for a noninvasive, allergic fungal disease and can help reassure clinicians intraoperatively and guide clinical management.
AB - BACKGROUND: Allergic fungal sinusitis (AFS) is a newly recognized form of sinusitis characterized by opacification of the paranasal sinuses by 'allergic mucin' (AM) admixed with scattered fungal organisms. AM consists of necrotic, or partially necrotic, eosinophils and Charcot-Leyden crystals suspended in lakes of laminated, mucinous material. AFS is characterized by the absence of bone or soft tissue invasion, purulent exudate or granulomatous inflammation. Clinically, it is important to differentiate AFS from both acute invasive fungal sinusitis and noninvasive mycetoma because the three diseases are treated with different modalities and have different prognoses. Although the radiologic features of AFS are often characteristic, occasionally it may be difficult to exclude neoplasia. CASES: Two cases of AFS, in which intraoperative diagnosis was made on the basis of the presence of both AM and fungal organisms, are reported. CONCLUSION: Cytologic diagnosis of AFS can be made from intraoperative sinus aspirates from the presence of AM and fungal elements. AM and fungi provide presumptive evidence for a noninvasive, allergic fungal disease and can help reassure clinicians intraoperatively and guide clinical management.
KW - Allergic fungal sinusitis
KW - Allergy
KW - Aspiration biopsy
KW - Intraoperative period
KW - Sinusitis
UR - http://www.scopus.com/inward/record.url?scp=0032936168&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032936168&partnerID=8YFLogxK
M3 - Article
C2 - 10097723
AN - SCOPUS:0032936168
VL - 43
SP - 268
EP - 272
JO - Acta Cytologica
JF - Acta Cytologica
SN - 0001-5547
IS - 2
ER -