Allergic fungal sinusitis: A report of two cases with diagnosis by intraoperative aspiration cytology

Vicki J. Schnadig, Christopher H. Rassekh, William K. Gourley

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

BACKGROUND: Allergic fungal sinusitis (AFS) is a newly recognized form of sinusitis characterized by opacification of the paranasal sinuses by 'allergic mucin' (AM) admixed with scattered fungal organisms. AM consists of necrotic, or partially necrotic, eosinophils and Charcot-Leyden crystals suspended in lakes of laminated, mucinous material. AFS is characterized by the absence of bone or soft tissue invasion, purulent exudate or granulomatous inflammation. Clinically, it is important to differentiate AFS from both acute invasive fungal sinusitis and noninvasive mycetoma because the three diseases are treated with different modalities and have different prognoses. Although the radiologic features of AFS are often characteristic, occasionally it may be difficult to exclude neoplasia. CASES: Two cases of AFS, in which intraoperative diagnosis was made on the basis of the presence of both AM and fungal organisms, are reported. CONCLUSION: Cytologic diagnosis of AFS can be made from intraoperative sinus aspirates from the presence of AM and fungal elements. AM and fungi provide presumptive evidence for a noninvasive, allergic fungal disease and can help reassure clinicians intraoperatively and guide clinical management.

Original languageEnglish (US)
Pages (from-to)268-272
Number of pages5
JournalActa Cytologica
Volume43
Issue number2
StatePublished - 1999

Fingerprint

Sinusitis
Cell Biology
Mucins
Mycetoma
Mycoses
Paranasal Sinuses
Exudates and Transudates
Lakes
Eosinophils
Fungi
Inflammation
Bone and Bones

Keywords

  • Allergic fungal sinusitis
  • Allergy
  • Aspiration biopsy
  • Intraoperative period
  • Sinusitis

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology
  • Histology

Cite this

Schnadig, V. J., Rassekh, C. H., & Gourley, W. K. (1999). Allergic fungal sinusitis: A report of two cases with diagnosis by intraoperative aspiration cytology. Acta Cytologica, 43(2), 268-272.

Allergic fungal sinusitis : A report of two cases with diagnosis by intraoperative aspiration cytology. / Schnadig, Vicki J.; Rassekh, Christopher H.; Gourley, William K.

In: Acta Cytologica, Vol. 43, No. 2, 1999, p. 268-272.

Research output: Contribution to journalArticle

Schnadig, VJ, Rassekh, CH & Gourley, WK 1999, 'Allergic fungal sinusitis: A report of two cases with diagnosis by intraoperative aspiration cytology', Acta Cytologica, vol. 43, no. 2, pp. 268-272.
Schnadig, Vicki J. ; Rassekh, Christopher H. ; Gourley, William K. / Allergic fungal sinusitis : A report of two cases with diagnosis by intraoperative aspiration cytology. In: Acta Cytologica. 1999 ; Vol. 43, No. 2. pp. 268-272.
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