Allopurinol-induced nephrotoxicity: Protection by the antioxidant, butylated hydroxytoluene

Naseem Ansari, S. Rajaraman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The present study was conducted to provide morphological evidence for allopurinol-induced nephrotoxicity in rats and its prevention by the antioxidant butylated hydroxytoluene (BHT). The kidneys of male Sprague Dawley rats fed a diet containing 0.3% allopurinol for 25 days exhibited a marked increase in the weight (2.5 times) as compared to the controls (without allopurinol). Upon microscopic examination, extensive tubulo- interstitial injury leading to structural damage was observed. Feeding BHT (0.4%) along with 0.3% allopurinol brought about a remarkable amelioration of the nephrotoxicity. The results indicate that usage of BHT along with the antiurecemic drug, allopurinol, may be helpful in improving the allopurinol- induced nephrotoxicity observed in some gout patients.

Original languageEnglish (US)
Pages (from-to)221-229
Number of pages9
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume75
Issue number2
StatePublished - 1992

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Butylated Hydroxytoluene
Allopurinol
Antioxidants
Rats
Gout
Nutrition
Sprague Dawley Rats
Microscopic examination
Diet
Kidney
Weights and Measures
Wounds and Injuries
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

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abstract = "The present study was conducted to provide morphological evidence for allopurinol-induced nephrotoxicity in rats and its prevention by the antioxidant butylated hydroxytoluene (BHT). The kidneys of male Sprague Dawley rats fed a diet containing 0.3{\%} allopurinol for 25 days exhibited a marked increase in the weight (2.5 times) as compared to the controls (without allopurinol). Upon microscopic examination, extensive tubulo- interstitial injury leading to structural damage was observed. Feeding BHT (0.4{\%}) along with 0.3{\%} allopurinol brought about a remarkable amelioration of the nephrotoxicity. The results indicate that usage of BHT along with the antiurecemic drug, allopurinol, may be helpful in improving the allopurinol- induced nephrotoxicity observed in some gout patients.",
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