Allopurinol-induced nephrotoxicity: Protection by the antioxidant, butylated hydroxytoluene

N. H. Ansari, S. Rajaraman

    Research output: Contribution to journalArticle

    6 Scopus citations

    Abstract

    The present study was conducted to provide morphological evidence for allopurinol-induced nephrotoxicity in rats and its prevention by the antioxidant butylated hydroxytoluene (BHT). The kidneys of male Sprague Dawley rats fed a diet containing 0.3% allopurinol for 25 days exhibited a marked increase in the weight (2.5 times) as compared to the controls (without allopurinol). Upon microscopic examination, extensive tubulo- interstitial injury leading to structural damage was observed. Feeding BHT (0.4%) along with 0.3% allopurinol brought about a remarkable amelioration of the nephrotoxicity. The results indicate that usage of BHT along with the antiurecemic drug, allopurinol, may be helpful in improving the allopurinol- induced nephrotoxicity observed in some gout patients.

    Original languageEnglish (US)
    Pages (from-to)221-229
    Number of pages9
    JournalResearch Communications in Chemical Pathology and Pharmacology
    Volume75
    Issue number2
    StatePublished - Jan 1 1992

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine
    • Toxicology
    • Pharmacology
    • Pharmacology, Toxicology and Pharmaceutics(all)

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