Abstract
The present study was conducted to provide morphological evidence for allopurinol-induced nephrotoxicity in rats and its prevention by the antioxidant butylated hydroxytoluene (BHT). The kidneys of male Sprague Dawley rats fed a diet containing 0.3% allopurinol for 25 days exhibited a marked increase in the weight (2.5 times) as compared to the controls (without allopurinol). Upon microscopic examination, extensive tubulo- interstitial injury leading to structural damage was observed. Feeding BHT (0.4%) along with 0.3% allopurinol brought about a remarkable amelioration of the nephrotoxicity. The results indicate that usage of BHT along with the antiurecemic drug, allopurinol, may be helpful in improving the allopurinol- induced nephrotoxicity observed in some gout patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 221-229 |
| Number of pages | 9 |
| Journal | Research Communications in Chemical Pathology and Pharmacology |
| Volume | 75 |
| Issue number | 2 |
| State | Published - 1992 |
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ASJC Scopus subject areas
- Pharmacology
- Toxicology
Cite this
Allopurinol-induced nephrotoxicity : Protection by the antioxidant, butylated hydroxytoluene. / Ansari, Naseem; Rajaraman, S.
In: Research Communications in Chemical Pathology and Pharmacology, Vol. 75, No. 2, 1992, p. 221-229.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Allopurinol-induced nephrotoxicity
T2 - Protection by the antioxidant, butylated hydroxytoluene
AU - Ansari, Naseem
AU - Rajaraman, S.
PY - 1992
Y1 - 1992
N2 - The present study was conducted to provide morphological evidence for allopurinol-induced nephrotoxicity in rats and its prevention by the antioxidant butylated hydroxytoluene (BHT). The kidneys of male Sprague Dawley rats fed a diet containing 0.3% allopurinol for 25 days exhibited a marked increase in the weight (2.5 times) as compared to the controls (without allopurinol). Upon microscopic examination, extensive tubulo- interstitial injury leading to structural damage was observed. Feeding BHT (0.4%) along with 0.3% allopurinol brought about a remarkable amelioration of the nephrotoxicity. The results indicate that usage of BHT along with the antiurecemic drug, allopurinol, may be helpful in improving the allopurinol- induced nephrotoxicity observed in some gout patients.
AB - The present study was conducted to provide morphological evidence for allopurinol-induced nephrotoxicity in rats and its prevention by the antioxidant butylated hydroxytoluene (BHT). The kidneys of male Sprague Dawley rats fed a diet containing 0.3% allopurinol for 25 days exhibited a marked increase in the weight (2.5 times) as compared to the controls (without allopurinol). Upon microscopic examination, extensive tubulo- interstitial injury leading to structural damage was observed. Feeding BHT (0.4%) along with 0.3% allopurinol brought about a remarkable amelioration of the nephrotoxicity. The results indicate that usage of BHT along with the antiurecemic drug, allopurinol, may be helpful in improving the allopurinol- induced nephrotoxicity observed in some gout patients.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026528653&partnerID=8YFLogxK
M3 - Article
VL - 75
SP - 221
EP - 229
JO - Research Communications in Chemical Pathology and Pharmacology
JF - Research Communications in Chemical Pathology and Pharmacology
SN - 0034-5164
IS - 2
ER -