The present study was conducted to provide morphological evidence for allopurinol-induced nephrotoxicity in rats and its prevention by the antioxidant butylated hydroxytoluene (BHT). The kidneys of male Sprague Dawley rats fed a diet containing 0.3% allopurinol for 25 days exhibited a marked increase in the weight (2.5 times) as compared to the controls (without allopurinol). Upon microscopic examination, extensive tubulo- interstitial injury leading to structural damage was observed. Feeding BHT (0.4%) along with 0.3% allopurinol brought about a remarkable amelioration of the nephrotoxicity. The results indicate that usage of BHT along with the antiurecemic drug, allopurinol, may be helpful in improving the allopurinol- induced nephrotoxicity observed in some gout patients.
|Original language||English (US)|
|Number of pages||9|
|Journal||Research Communications in Chemical Pathology and Pharmacology|
|State||Published - Jan 1 1992|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)