Abstract
The chemistry, industrial usage, general toxicity, and experimenal use of allylamine are briefly reviewed. This highly reactive unsaturated alkylamine has had industrial applications in a variety of organic processes, and continues to be utilized, although accurate data concerning production is not readily available. The general toxic effects of the freebase from are primarily related to irritationp of the mucous membranes, whereas the relatively long history of experimental use of this chemical has emphasized its' extraordinary deleterious effets on heart and vascular tissue. Allylamine has been given by a variety of routes to many species in attempts to cause lesions which mimic human acute vasculitis, acute myocardial necrosis, and atherosclerosis; example of typical lesions are illustrated. More recent in vivo and in vitro experimental work concerning the cellular toxicity of allylamine are summarized, and possible mechanisms of this chemicals' toxic action are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 129-145 |
| Number of pages | 17 |
| Journal | Toxicology |
| Volume | 44 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1987 |
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Keywords
- Allylamine
- Cardiovascular toxicity
ASJC Scopus subject areas
- Toxicology
Cite this
Allylamine cardiovascular toxicity. / Boor, Paul J.; Hysmith, Robert M.
In: Toxicology, Vol. 44, No. 2, 1987, p. 129-145.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Allylamine cardiovascular toxicity
AU - Boor, Paul J.
AU - Hysmith, Robert M.
PY - 1987
Y1 - 1987
N2 - The chemistry, industrial usage, general toxicity, and experimenal use of allylamine are briefly reviewed. This highly reactive unsaturated alkylamine has had industrial applications in a variety of organic processes, and continues to be utilized, although accurate data concerning production is not readily available. The general toxic effects of the freebase from are primarily related to irritationp of the mucous membranes, whereas the relatively long history of experimental use of this chemical has emphasized its' extraordinary deleterious effets on heart and vascular tissue. Allylamine has been given by a variety of routes to many species in attempts to cause lesions which mimic human acute vasculitis, acute myocardial necrosis, and atherosclerosis; example of typical lesions are illustrated. More recent in vivo and in vitro experimental work concerning the cellular toxicity of allylamine are summarized, and possible mechanisms of this chemicals' toxic action are discussed.
AB - The chemistry, industrial usage, general toxicity, and experimenal use of allylamine are briefly reviewed. This highly reactive unsaturated alkylamine has had industrial applications in a variety of organic processes, and continues to be utilized, although accurate data concerning production is not readily available. The general toxic effects of the freebase from are primarily related to irritationp of the mucous membranes, whereas the relatively long history of experimental use of this chemical has emphasized its' extraordinary deleterious effets on heart and vascular tissue. Allylamine has been given by a variety of routes to many species in attempts to cause lesions which mimic human acute vasculitis, acute myocardial necrosis, and atherosclerosis; example of typical lesions are illustrated. More recent in vivo and in vitro experimental work concerning the cellular toxicity of allylamine are summarized, and possible mechanisms of this chemicals' toxic action are discussed.
KW - Allylamine
KW - Cardiovascular toxicity
UR - http://www.scopus.com/inward/record.url?scp=0023179353&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023179353&partnerID=8YFLogxK
U2 - 10.1016/0300-483X(87)90144-2
DO - 10.1016/0300-483X(87)90144-2
M3 - Article
C2 - 3551196
AN - SCOPUS:0023179353
VL - 44
SP - 129
EP - 145
JO - Toxicology
JF - Toxicology
SN - 0300-483X
IS - 2
ER -