TY - JOUR
T1 - Alpha-Lipoic Acid Attenuates Oxidative Damage in Organs After Sepsis
AU - Petronilho, Fabricia
AU - Florentino, Drielly
AU - Danielski, Lucinéia Gainski
AU - Vieira, Luiz Carlos
AU - Martins, Maryane Modolon
AU - Vieira, Andriele
AU - Bonfante, Sandra
AU - Goldim, Mariana Pereira
AU - Vuolo, Francieli
N1 - Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Sepsis progression is linked with the imbalance between reactive oxygen species and antioxidant enzymes. Thus, the aim of this study was to evaluate the effect of alpha-lipoic acid (ALA), a powerful antioxidant, in organs of rats submitted to sepsis. Male Wistar rats were subjected to sepsis by cecal ligation puncture (CLP) and treated with ALA or vehicle. After CLP (12 and 24 h), the myeloperoxidase (MPO) activity, protein and lipid oxidative damage, and antioxidant enzymes in the liver, kidney, heart, and lung were evaluated. ALA was effective in reducing MPO activity, lipid peroxidation in the liver, and protein carbonylation only in the kidney in 12 h after CLP. In 12 h, SOD activity increased in the kidney and CAT activity in the liver and kidney with ALA treatment. Thus, ALA was able to reduce the inflammation and oxidative stress in the liver and kidney after sepsis in rats.
AB - Sepsis progression is linked with the imbalance between reactive oxygen species and antioxidant enzymes. Thus, the aim of this study was to evaluate the effect of alpha-lipoic acid (ALA), a powerful antioxidant, in organs of rats submitted to sepsis. Male Wistar rats were subjected to sepsis by cecal ligation puncture (CLP) and treated with ALA or vehicle. After CLP (12 and 24 h), the myeloperoxidase (MPO) activity, protein and lipid oxidative damage, and antioxidant enzymes in the liver, kidney, heart, and lung were evaluated. ALA was effective in reducing MPO activity, lipid peroxidation in the liver, and protein carbonylation only in the kidney in 12 h after CLP. In 12 h, SOD activity increased in the kidney and CAT activity in the liver and kidney with ALA treatment. Thus, ALA was able to reduce the inflammation and oxidative stress in the liver and kidney after sepsis in rats.
KW - alpha-lipoic acid
KW - organ failure
KW - oxidative damage
KW - sepsis
UR - http://www.scopus.com/inward/record.url?scp=84958051858&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84958051858&partnerID=8YFLogxK
U2 - 10.1007/s10753-015-0256-4
DO - 10.1007/s10753-015-0256-4
M3 - Article
C2 - 26431839
AN - SCOPUS:84958051858
SN - 0360-3997
VL - 39
SP - 357
EP - 365
JO - Inflammation
JF - Inflammation
IS - 1
ER -