Alphavirus neurovirulence

Katherine Taylor, Slobodan Paessler

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Due to their parasitic, obligate, intracellular nature, evolution favors viruses with the ability to evade the barriers and impediments the host organism utilizes to limit their ability to replicate or cause cellular dysfunction. Avoidance of host defense mechanisms and successful replication often leads to virulence, the ability to cause fatal disease. Neurovirulent viruses alter the highly sensitive nature and critical functioning of the central nervous system (CNS) leading to fatal encephalitis or, in the event of recovery, severe neurological sequelae. With 20 viruses known to cause human encephalitis, arboviruses (arthropod-borne viruses) represent a signicant public health threat as emerging infectious diseases both in the United States and worldwide. The focus of this review, arboviruses in the Alphavirus genus in the family Togaviridae, contains three viruses capable of causing human encephalitis: Venezuelan equine encephalitis virus (VEEV), eastern equine encephalitis virus (EEEV), and western equine encephalitis virus (WEEV). No specic therapy or vaccine is currently available against these viruses.

Original languageEnglish (US)
Title of host publicationNeuroviral Infections
Subtitle of host publicationRNA Viruses and Retroviruses
PublisherCRC Press
Pages3-20
Number of pages18
ISBN (Electronic)9781466567238
ISBN (Print)9781466567207
DOIs
StatePublished - Jan 1 2013

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Alphavirus
Viruses
Encephalitis
Arboviruses
Western Equine Encephalitis Viruses
Eastern equine encephalitis virus
Togaviridae
Venezuelan Equine Encephalitis Viruses
Emerging Communicable Diseases
Active Immunotherapy
Virulence
Central Nervous System
Public Health

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Taylor, K., & Paessler, S. (2013). Alphavirus neurovirulence. In Neuroviral Infections: RNA Viruses and Retroviruses (pp. 3-20). CRC Press. https://doi.org/10.1201/b13908

Alphavirus neurovirulence. / Taylor, Katherine; Paessler, Slobodan.

Neuroviral Infections: RNA Viruses and Retroviruses. CRC Press, 2013. p. 3-20.

Research output: Chapter in Book/Report/Conference proceedingChapter

Taylor, K & Paessler, S 2013, Alphavirus neurovirulence. in Neuroviral Infections: RNA Viruses and Retroviruses. CRC Press, pp. 3-20. https://doi.org/10.1201/b13908
Taylor K, Paessler S. Alphavirus neurovirulence. In Neuroviral Infections: RNA Viruses and Retroviruses. CRC Press. 2013. p. 3-20 https://doi.org/10.1201/b13908
Taylor, Katherine ; Paessler, Slobodan. / Alphavirus neurovirulence. Neuroviral Infections: RNA Viruses and Retroviruses. CRC Press, 2013. pp. 3-20
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