Alphaviruses: Population genetics and determinants of emergence

Scott C. Weaver, Richard Winegar, Ian D. Manger, Naomi L. Forrester

Research output: Contribution to journalReview articlepeer-review

122 Scopus citations


Alphaviruses are responsible for several medically important emerging diseases and are also significant veterinary pathogens. Due to the aerosol infectivity of some alphaviruses and their ability to cause severe, sometimes fatal neurologic diseases, they are also of biodefense importance. This review discusses the ecology, epidemiology and molecular virology of the alphaviruses, then focuses on three of the most important members of the genus: Venezuelan and eastern equine encephalitis and chikungunya viruses, with emphasis on their genetics and emergence mechanisms, and how current knowledge as well as gaps influence our ability to detect and determine the source of both natural outbreaks and potential use for bioterrorism. This article is one of a series in Antiviral Research on the genetic diversity of emerging viruses.

Original languageEnglish (US)
Pages (from-to)242-257
Number of pages16
JournalAntiviral research
Issue number3
StatePublished - Jun 2012


  • Alphavirus
  • Arbovirus
  • Biodefense
  • Ecology
  • Epidemiology
  • Genetics

ASJC Scopus subject areas

  • Pharmacology
  • Virology


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