Abstract
Alphaviruses are responsible for several medically important emerging diseases and are also significant veterinary pathogens. Due to the aerosol infectivity of some alphaviruses and their ability to cause severe, sometimes fatal neurologic diseases, they are also of biodefense importance. This review discusses the ecology, epidemiology and molecular virology of the alphaviruses, then focuses on three of the most important members of the genus: Venezuelan and eastern equine encephalitis and chikungunya viruses, with emphasis on their genetics and emergence mechanisms, and how current knowledge as well as gaps influence our ability to detect and determine the source of both natural outbreaks and potential use for bioterrorism. This article is one of a series in Antiviral Research on the genetic diversity of emerging viruses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 242-257 |
| Number of pages | 16 |
| Journal | Antiviral Research |
| Volume | 94 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 2012 |
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Keywords
- Alphavirus
- Arbovirus
- Biodefense
- Ecology
- Epidemiology
- Genetics
ASJC Scopus subject areas
- Virology
- Pharmacology
Cite this
Alphaviruses : Population genetics and determinants of emergence. / Weaver, Scott; Winegar, Richard; Manger, Ian D.; Forrester, Naomi L.
In: Antiviral Research, Vol. 94, No. 3, 06.2012, p. 242-257.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alphaviruses
T2 - Population genetics and determinants of emergence
AU - Weaver, Scott
AU - Winegar, Richard
AU - Manger, Ian D.
AU - Forrester, Naomi L.
PY - 2012/6
Y1 - 2012/6
N2 - Alphaviruses are responsible for several medically important emerging diseases and are also significant veterinary pathogens. Due to the aerosol infectivity of some alphaviruses and their ability to cause severe, sometimes fatal neurologic diseases, they are also of biodefense importance. This review discusses the ecology, epidemiology and molecular virology of the alphaviruses, then focuses on three of the most important members of the genus: Venezuelan and eastern equine encephalitis and chikungunya viruses, with emphasis on their genetics and emergence mechanisms, and how current knowledge as well as gaps influence our ability to detect and determine the source of both natural outbreaks and potential use for bioterrorism. This article is one of a series in Antiviral Research on the genetic diversity of emerging viruses.
AB - Alphaviruses are responsible for several medically important emerging diseases and are also significant veterinary pathogens. Due to the aerosol infectivity of some alphaviruses and their ability to cause severe, sometimes fatal neurologic diseases, they are also of biodefense importance. This review discusses the ecology, epidemiology and molecular virology of the alphaviruses, then focuses on three of the most important members of the genus: Venezuelan and eastern equine encephalitis and chikungunya viruses, with emphasis on their genetics and emergence mechanisms, and how current knowledge as well as gaps influence our ability to detect and determine the source of both natural outbreaks and potential use for bioterrorism. This article is one of a series in Antiviral Research on the genetic diversity of emerging viruses.
KW - Alphavirus
KW - Arbovirus
KW - Biodefense
KW - Ecology
KW - Epidemiology
KW - Genetics
UR - http://www.scopus.com/inward/record.url?scp=84861228370&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861228370&partnerID=8YFLogxK
U2 - 10.1016/j.antiviral.2012.04.002
DO - 10.1016/j.antiviral.2012.04.002
M3 - Article
C2 - 22522323
AN - SCOPUS:84861228370
VL - 94
SP - 242
EP - 257
JO - Antiviral Research
JF - Antiviral Research
SN - 0166-3542
IS - 3
ER -