Alteration of spontaneous firing rate of primary myelinated afferents by ATP in adjuvant-induced inflamed rats

Yi Hong Zhang, Yong Chen, Zhi Qi Zhao

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The action of adenosine 5′-triphosphate (ATP) on primary myelinated mechanosensitive afferents was investigated in adjuvant-induced inflamed rats. ATP injected intravenously increased the spontaneous firing rate in most of the A fibers from sciatic nerve innervating inflamed hindpaw, whereas it affected only a few units in normal rats. The effects of ATP were blocked or attenuated by competitive P2 receptor antagonist suramin or reactive blue 2 in most of the fibers tested. Degranulation of mast cells with compound 48/80 did not change the response rate of afferents to ATP in inflamed rats while chemical sympathectomy with 6-hydroxydopamine decreased it to some extent, suggesting an involvement of sympathetic efferents in mediating ATP effects. The results support the view that ATP could change the activity of large mechanosensitive afferents via P2 receptors under state of inflammation, which may be related to touch-evoked pain.

Original languageEnglish (US)
Pages (from-to)141-144
Number of pages4
JournalBrain Research Bulletin
Volume54
Issue number2
DOIs
StatePublished - Jan 15 2001
Externally publishedYes

Fingerprint

Adenosine Triphosphate
Cibacron Blue F 3GA
Chemical Sympathectomy
p-Methoxy-N-methylphenethylamine
Suramin
Myelinated Nerve Fibers
Oxidopamine
Touch
Sciatic Nerve
Mast Cells
Inflammation
Pain

Keywords

  • Adenosine 5′-triphosphate
  • Afferent fibers
  • Inflammation
  • P2 receptor
  • Pain
  • Sensory neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Alteration of spontaneous firing rate of primary myelinated afferents by ATP in adjuvant-induced inflamed rats. / Zhang, Yi Hong; Chen, Yong; Zhao, Zhi Qi.

In: Brain Research Bulletin, Vol. 54, No. 2, 15.01.2001, p. 141-144.

Research output: Contribution to journalArticle

Zhang, Yi Hong ; Chen, Yong ; Zhao, Zhi Qi. / Alteration of spontaneous firing rate of primary myelinated afferents by ATP in adjuvant-induced inflamed rats. In: Brain Research Bulletin. 2001 ; Vol. 54, No. 2. pp. 141-144.
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