Alteration of spontaneous firing rate of primary myelinated afferents by ATP in adjuvant-induced inflamed rats

Yi Hong Zhang; Yong Chen; Zhi Qi Zhao

doi:10.1016/S0361-9230(00)00422-6

Alteration of spontaneous firing rate of primary myelinated afferents by ATP in adjuvant-induced inflamed rats

Yi Hong Zhang, Yong Chen, Zhi Qi Zhao

Neuroscience & Cell

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The action of adenosine 5′-triphosphate (ATP) on primary myelinated mechanosensitive afferents was investigated in adjuvant-induced inflamed rats. ATP injected intravenously increased the spontaneous firing rate in most of the A fibers from sciatic nerve innervating inflamed hindpaw, whereas it affected only a few units in normal rats. The effects of ATP were blocked or attenuated by competitive P2 receptor antagonist suramin or reactive blue 2 in most of the fibers tested. Degranulation of mast cells with compound 48/80 did not change the response rate of afferents to ATP in inflamed rats while chemical sympathectomy with 6-hydroxydopamine decreased it to some extent, suggesting an involvement of sympathetic efferents in mediating ATP effects. The results support the view that ATP could change the activity of large mechanosensitive afferents via P2 receptors under state of inflammation, which may be related to touch-evoked pain.

Original language	English (US)
Pages (from-to)	141-144
Number of pages	4
Journal	Brain Research Bulletin
Volume	54
Issue number	2
DOIs	https://doi.org/10.1016/S0361-9230(00)00422-6
State	Published - Jan 15 2001

Keywords

Adenosine 5′-triphosphate
Afferent fibers
Inflammation
P2 receptor
Pain
Sensory neurons

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0361-9230(00)00422-6

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title = "Alteration of spontaneous firing rate of primary myelinated afferents by ATP in adjuvant-induced inflamed rats",

abstract = "The action of adenosine 5′-triphosphate (ATP) on primary myelinated mechanosensitive afferents was investigated in adjuvant-induced inflamed rats. ATP injected intravenously increased the spontaneous firing rate in most of the A fibers from sciatic nerve innervating inflamed hindpaw, whereas it affected only a few units in normal rats. The effects of ATP were blocked or attenuated by competitive P2 receptor antagonist suramin or reactive blue 2 in most of the fibers tested. Degranulation of mast cells with compound 48/80 did not change the response rate of afferents to ATP in inflamed rats while chemical sympathectomy with 6-hydroxydopamine decreased it to some extent, suggesting an involvement of sympathetic efferents in mediating ATP effects. The results support the view that ATP could change the activity of large mechanosensitive afferents via P2 receptors under state of inflammation, which may be related to touch-evoked pain.",

keywords = "Adenosine 5′-triphosphate, Afferent fibers, Inflammation, P2 receptor, Pain, Sensory neurons",

author = "Zhang, {Yi Hong} and Yong Chen and Zhao, {Zhi Qi}",

note = "Funding Information: The authors wish to thank Prof. Yumin Liu for his help in the preparation of this manuscript. This project was supported by grants from Shanghai-Unilever Research and Development Fund, Key Laboratory of Neurobiology, Shanghai Academy of Biological Science and National Basic Research Program (G1999054000) of China.",

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doi = "10.1016/S0361-9230(00)00422-6",

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AU - Zhang, Yi Hong

AU - Chen, Yong

AU - Zhao, Zhi Qi

N1 - Funding Information: The authors wish to thank Prof. Yumin Liu for his help in the preparation of this manuscript. This project was supported by grants from Shanghai-Unilever Research and Development Fund, Key Laboratory of Neurobiology, Shanghai Academy of Biological Science and National Basic Research Program (G1999054000) of China.

PY - 2001/1/15

Y1 - 2001/1/15

N2 - The action of adenosine 5′-triphosphate (ATP) on primary myelinated mechanosensitive afferents was investigated in adjuvant-induced inflamed rats. ATP injected intravenously increased the spontaneous firing rate in most of the A fibers from sciatic nerve innervating inflamed hindpaw, whereas it affected only a few units in normal rats. The effects of ATP were blocked or attenuated by competitive P2 receptor antagonist suramin or reactive blue 2 in most of the fibers tested. Degranulation of mast cells with compound 48/80 did not change the response rate of afferents to ATP in inflamed rats while chemical sympathectomy with 6-hydroxydopamine decreased it to some extent, suggesting an involvement of sympathetic efferents in mediating ATP effects. The results support the view that ATP could change the activity of large mechanosensitive afferents via P2 receptors under state of inflammation, which may be related to touch-evoked pain.

AB - The action of adenosine 5′-triphosphate (ATP) on primary myelinated mechanosensitive afferents was investigated in adjuvant-induced inflamed rats. ATP injected intravenously increased the spontaneous firing rate in most of the A fibers from sciatic nerve innervating inflamed hindpaw, whereas it affected only a few units in normal rats. The effects of ATP were blocked or attenuated by competitive P2 receptor antagonist suramin or reactive blue 2 in most of the fibers tested. Degranulation of mast cells with compound 48/80 did not change the response rate of afferents to ATP in inflamed rats while chemical sympathectomy with 6-hydroxydopamine decreased it to some extent, suggesting an involvement of sympathetic efferents in mediating ATP effects. The results support the view that ATP could change the activity of large mechanosensitive afferents via P2 receptors under state of inflammation, which may be related to touch-evoked pain.

KW - Adenosine 5′-triphosphate

KW - Afferent fibers

KW - Inflammation

KW - P2 receptor

KW - Pain

KW - Sensory neurons

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Alteration of spontaneous firing rate of primary myelinated afferents by ATP in adjuvant-induced inflamed rats

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