Alterations in host regulatory glycolytic enzymes during pathogenesis of primate malaria and following chloroquine therapy

S. K. Sahni; N. Saxena; S. K. Puri; G. P. Dutta; V. C. Pandey

doi:10.1016/0020-7519(92)90110-7

Alterations in host regulatory glycolytic enzymes during pathogenesis of primate malaria and following chloroquine therapy

S. K. Sahni, N. Saxena, S. K. Puri, G. P. Dutta, V. C. Pandey

Research output: Contribution to journal › Article › peer-review

Abstract

Hexokinase, phosphofructokinase and pyruvate kinase, the regulatory enzymes of the glycolytic sequence, showed progressive increases in their activities with the rise of parasitaemia in Plasmodium knowlesi-infected rhesus monkey serum and red blood cells. Chloroquine therapy cleared the parasitaemia in 72 h and brought the elevated levels of these enzymes back to almost normal in about 30 days.

Original language	English (US)
Pages (from-to)	247-249
Number of pages	3
Journal	International Journal for Parasitology
Volume	22
Issue number	2
DOIs	https://doi.org/10.1016/0020-7519(92)90110-7
State	Published - Apr 1992
Externally published	Yes

Keywords

Chloroquine
Plasmodium knowlesi
hexokinase
monkeys
phosphofructokinase
pyruvate kinase

ASJC Scopus subject areas

Parasitology
Infectious Diseases

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10.1016/0020-7519(92)90110-7

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title = "Alterations in host regulatory glycolytic enzymes during pathogenesis of primate malaria and following chloroquine therapy",

abstract = "Hexokinase, phosphofructokinase and pyruvate kinase, the regulatory enzymes of the glycolytic sequence, showed progressive increases in their activities with the rise of parasitaemia in Plasmodium knowlesi-infected rhesus monkey serum and red blood cells. Chloroquine therapy cleared the parasitaemia in 72 h and brought the elevated levels of these enzymes back to almost normal in about 30 days.",

keywords = "Chloroquine, Plasmodium knowlesi, hexokinase, monkeys, phosphofructokinase, pyruvate kinase",

author = "Sahni, {S. K.} and N. Saxena and Puri, {S. K.} and Dutta, {G. P.} and Pandey, {V. C.}",

year = "1992",

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language = "English (US)",

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T1 - Alterations in host regulatory glycolytic enzymes during pathogenesis of primate malaria and following chloroquine therapy

AU - Sahni, S. K.

AU - Saxena, N.

AU - Puri, S. K.

AU - Dutta, G. P.

AU - Pandey, V. C.

PY - 1992/4

Y1 - 1992/4

N2 - Hexokinase, phosphofructokinase and pyruvate kinase, the regulatory enzymes of the glycolytic sequence, showed progressive increases in their activities with the rise of parasitaemia in Plasmodium knowlesi-infected rhesus monkey serum and red blood cells. Chloroquine therapy cleared the parasitaemia in 72 h and brought the elevated levels of these enzymes back to almost normal in about 30 days.

AB - Hexokinase, phosphofructokinase and pyruvate kinase, the regulatory enzymes of the glycolytic sequence, showed progressive increases in their activities with the rise of parasitaemia in Plasmodium knowlesi-infected rhesus monkey serum and red blood cells. Chloroquine therapy cleared the parasitaemia in 72 h and brought the elevated levels of these enzymes back to almost normal in about 30 days.

KW - Chloroquine

KW - Plasmodium knowlesi

KW - hexokinase

KW - monkeys

KW - phosphofructokinase

KW - pyruvate kinase

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JO - International Journal for Parasitology

JF - International Journal for Parasitology

IS - 2

ER -

Alterations in host regulatory glycolytic enzymes during pathogenesis of primate malaria and following chloroquine therapy

Abstract

Keywords

ASJC Scopus subject areas

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