Alterations in host regulatory glycolytic enzymes during pathogenesis of primate malaria and following chloroquine therapy

S. K. Sahni, N. Saxena, S. K. Puri, G. P. Dutta, V. C. Pandey

Research output: Contribution to journalArticle

Abstract

Hexokinase, phosphofructokinase and pyruvate kinase, the regulatory enzymes of the glycolytic sequence, showed progressive increases in their activities with the rise of parasitaemia in Plasmodium knowlesi-infected rhesus monkey serum and red blood cells. Chloroquine therapy cleared the parasitaemia in 72 h and brought the elevated levels of these enzymes back to almost normal in about 30 days.

Original languageEnglish (US)
Pages (from-to)247-249
Number of pages3
JournalInternational Journal for Parasitology
Volume22
Issue number2
DOIs
StatePublished - Apr 1992
Externally publishedYes

Keywords

  • Chloroquine
  • Plasmodium knowlesi
  • hexokinase
  • monkeys
  • phosphofructokinase
  • pyruvate kinase

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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