Alterations in host regulatory glycolytic enzymes during pathogenesis of primate malaria and following chloroquine therapy

Sanjeev Sahni, N. Saxena, S. K. Puri, G. P. Dutta, V. C. Pandey

Research output: Contribution to journalArticle

Abstract

Hexokinase, phosphofructokinase and pyruvate kinase, the regulatory enzymes of the glycolytic sequence, showed progressive increases in their activities with the rise of parasitaemia in Plasmodium knowlesi-infected rhesus monkey serum and red blood cells. Chloroquine therapy cleared the parasitaemia in 72 h and brought the elevated levels of these enzymes back to almost normal in about 30 days.

Original languageEnglish (US)
Pages (from-to)247-249
Number of pages3
JournalInternational Journal for Parasitology
Volume22
Issue number2
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Parasitemia
Chloroquine
Primates
Malaria
Plasmodium knowlesi
Phosphofructokinases
Hexokinase
Pyruvate Kinase
Enzymes
Macaca mulatta
Erythrocytes
Therapeutics
Serum

Keywords

  • Chloroquine
  • hexokinase
  • monkeys
  • phosphofructokinase
  • Plasmodium knowlesi
  • pyruvate kinase

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Alterations in host regulatory glycolytic enzymes during pathogenesis of primate malaria and following chloroquine therapy. / Sahni, Sanjeev; Saxena, N.; Puri, S. K.; Dutta, G. P.; Pandey, V. C.

In: International Journal for Parasitology, Vol. 22, No. 2, 1992, p. 247-249.

Research output: Contribution to journalArticle

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AU - Pandey, V. C.

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