Alterations in intracellular lymphocyte metabolism induced by infection and injury

Yuan Lin Dong, Tina Yan, David Herndon, J. Paul Waymack

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The effects of burn injury and sepsis on intracellular lymphocyte metabolism were evaluated using a rat model. Adult Lewis rats were subjected to a sham burn, a 30% full-thickness burn, or a 30% full-thickness burn which was infected with Pseudomonas aeruginosa. One week later the animals were sacrificed, and the splenic lymphocytes were harvested and cultured for 24 hr with mitogen stimulation. Lymphocytes from the burned-infected rats were found to utilize more glucose and certain amino acids than did lymphocytes obtained from the other two groups. Lymphocytes obtained from the burned-infected group had lower levels of the immunologically important enzyme, adenosine deaminase, than did the lymphocytes obtained from the other two groups. In summary, sepsis appears to alter a number of intracellular lymphocyte metabolic processes. These alterations may be found to be predictive of early sepsis.

Original languageEnglish (US)
Pages (from-to)293-297
Number of pages5
JournalJournal of Surgical Research
Volume53
Issue number3
DOIs
StatePublished - 1992

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Lymphocytes
Wounds and Injuries
Infection
Sepsis
Adenosine Deaminase
Lymphocyte Count
Mitogens
Pseudomonas aeruginosa
Amino Acids
Glucose
Enzymes

ASJC Scopus subject areas

  • Surgery

Cite this

Alterations in intracellular lymphocyte metabolism induced by infection and injury. / Dong, Yuan Lin; Yan, Tina; Herndon, David; Waymack, J. Paul.

In: Journal of Surgical Research, Vol. 53, No. 3, 1992, p. 293-297.

Research output: Contribution to journalArticle

Dong, Yuan Lin ; Yan, Tina ; Herndon, David ; Waymack, J. Paul. / Alterations in intracellular lymphocyte metabolism induced by infection and injury. In: Journal of Surgical Research. 1992 ; Vol. 53, No. 3. pp. 293-297.
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