Alterations in nitric oxide homeostasis during traumatic brain injury

Andrey V. Kozlov, Soheyl Bahrami, Heinz Redl, Csaba Szabo

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    Changes in nitric oxide (NO) levels have been often associated with various forms of trauma, including secondary damage after traumatic brain injury (TBI). Several studies demonstrate the upregulation of NO synthase (NOS) enzymes, and concomitant increases in brain NO levels, which contribute to the TBI-associated glutamate cytotoxicity, including the pathogenesis of mitochondrial dysfunction. TBI is also associated with elevated NO levels in remote organs, indicating that TBI can induce systemic changes in NO regulation, which can be either beneficial or detrimental. Here we review the possible mechanisms responsible for changes in NO metabolism during TBI. Better understanding of the changes in NO homeostasis in TBI will be necessary to design rational therapeutic approaches for TBI. This article is part of a Special Issue entitled: Immune and Metabolic Alterations in Trauma and Sepsis - edited by Raghavan Raju.

    Original languageEnglish (US)
    JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
    DOIs
    StateAccepted/In press - Oct 29 2016

    Fingerprint

    Nitric Oxide
    Homeostasis
    Traumatic Brain Injury
    Nitric Oxide Synthase
    Glutamic Acid
    Sepsis
    Up-Regulation
    Wounds and Injuries
    Brain
    Enzymes

    Keywords

    • Glutamate
    • Nitric oxide
    • Peroxynitrite
    • Traumatic brain injury

    ASJC Scopus subject areas

    • Molecular Medicine
    • Molecular Biology

    Cite this

    Alterations in nitric oxide homeostasis during traumatic brain injury. / Kozlov, Andrey V.; Bahrami, Soheyl; Redl, Heinz; Szabo, Csaba.

    In: Biochimica et Biophysica Acta - Molecular Basis of Disease, 29.10.2016.

    Research output: Contribution to journalArticle

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