Alterations in nitric oxide homeostasis during traumatic brain injury

Andrey V. Kozlov, Soheyl Bahrami, Heinz Redl, Csaba Szabo

    Research output: Contribution to journalArticle

    16 Scopus citations


    Changes in nitric oxide (NO) levels have been often associated with various forms of trauma, including secondary damage after traumatic brain injury (TBI). Several studies demonstrate the upregulation of NO synthase (NOS) enzymes, and concomitant increases in brain NO levels, which contribute to the TBI-associated glutamate cytotoxicity, including the pathogenesis of mitochondrial dysfunction. TBI is also associated with elevated NO levels in remote organs, indicating that TBI can induce systemic changes in NO regulation, which can be either beneficial or detrimental. Here we review the possible mechanisms responsible for changes in NO metabolism during TBI. Better understanding of the changes in NO homeostasis in TBI will be necessary to design rational therapeutic approaches for TBI. This article is part of a Special Issue entitled: Immune and Metabolic Alterations in Trauma and Sepsis - edited by Raghavan Raju.

    Original languageEnglish (US)
    JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
    StateAccepted/In press - Oct 29 2016


    • Glutamate
    • Nitric oxide
    • Peroxynitrite
    • Traumatic brain injury

    ASJC Scopus subject areas

    • Molecular Medicine
    • Molecular Biology

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