Alterations in nitric oxide homeostasis during traumatic brain injury

Andrey V. Kozlov, Soheyl Bahrami, Heinz Redl, Csaba Szabo

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

Changes in nitric oxide (NO) levels have been often associated with various forms of trauma, including secondary damage after traumatic brain injury (TBI). Several studies demonstrate the upregulation of NO synthase (NOS) enzymes, and concomitant increases in brain NO levels, which contribute to the TBI-associated glutamate cytotoxicity, including the pathogenesis of mitochondrial dysfunction. TBI is also associated with elevated NO levels in remote organs, indicating that TBI can induce systemic changes in NO regulation, which can be either beneficial or detrimental. Here we review the possible mechanisms responsible for changes in NO metabolism during TBI. Better understanding of the changes in NO homeostasis in TBI will be necessary to design rational therapeutic approaches for TBI. This article is part of a Special Issue entitled: Immune and Metabolic Alterations in Trauma and Sepsis edited by Dr. Raghavan Raju.

Original languageEnglish (US)
Pages (from-to)2627-2632
Number of pages6
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1863
Issue number10
DOIs
StatePublished - Oct 2017

Keywords

  • Glutamate
  • Nitric oxide
  • Peroxynitrite
  • Traumatic brain injury

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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