Alterations in renal stone risk factors after space flight

P. A. Whitson, R. A. Pietrzyk, C. Y C Pak, Nitza Cintron

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Exposure to the microgravity environment of space produces a number of physiological changes of metabolic and environmental origin that could increase the potential for renal stone formation. Metabolic, environmental and physicochemical factors that influence renal stone risk potential were examined in 24-hour urine samples from astronauts 10 days before launch and on landing day to provide an immediate postflight assessment of these factors. In addition, comparisons were made between male and female crewmembers, and between crewmembers on missions of less than 6 days and those on 6 to 10-day missions. Results suggest that immediately after space flight the risk of calcium oxalate and uric acid stone formation is increased as a result of metabolic (hypercalciuria, hypocitraturia, pH) and environmental (lower urine volume) derangements, some of which could reflect residual effects of having been exposed to microgravity.

Original languageEnglish (US)
Pages (from-to)803-807
Number of pages5
JournalJournal of Urology
Volume150
Issue number3
StatePublished - 1993
Externally publishedYes

Fingerprint

Weightlessness
Space Flight
Urine
Astronauts
Kidney
Hypercalciuria
Calcium Oxalate
Uric Acid

Keywords

  • aerospace medicine
  • kidney calculi
  • space flight
  • urinary calculi

ASJC Scopus subject areas

  • Urology

Cite this

Whitson, P. A., Pietrzyk, R. A., Pak, C. Y. C., & Cintron, N. (1993). Alterations in renal stone risk factors after space flight. Journal of Urology, 150(3), 803-807.

Alterations in renal stone risk factors after space flight. / Whitson, P. A.; Pietrzyk, R. A.; Pak, C. Y C; Cintron, Nitza.

In: Journal of Urology, Vol. 150, No. 3, 1993, p. 803-807.

Research output: Contribution to journalArticle

Whitson, PA, Pietrzyk, RA, Pak, CYC & Cintron, N 1993, 'Alterations in renal stone risk factors after space flight', Journal of Urology, vol. 150, no. 3, pp. 803-807.
Whitson PA, Pietrzyk RA, Pak CYC, Cintron N. Alterations in renal stone risk factors after space flight. Journal of Urology. 1993;150(3):803-807.
Whitson, P. A. ; Pietrzyk, R. A. ; Pak, C. Y C ; Cintron, Nitza. / Alterations in renal stone risk factors after space flight. In: Journal of Urology. 1993 ; Vol. 150, No. 3. pp. 803-807.
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