Alterations in stomach ghrelin production and in ghrelin-induced growth hormone secretion in the aged rat

Ella Englander, Guillermo Gomez, George H. Greeley

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Ghrelin is a recently discovered stomach hormone that stimulates growth hormone (GH) secretion, food intake, adiposity, and growth. In this report, we present new and previously published data from our laboratory showing that stomach ghrelin production and secretion are increased, and that GH release in response to exogenous ghrelin is enhanced in the aged rat. Together, these data suggest that the aging associated decline in GH secretion is not due to a reduction in stomach ghrelin secretion or a stimulatory action on GH release.

Original languageEnglish (US)
Pages (from-to)871-875
Number of pages5
JournalMechanisms of Ageing and Development
Volume125
Issue number12 SPEC.ISS.
DOIs
StatePublished - Dec 2004

Fingerprint

Ghrelin
Growth Hormone
Rats
Stomach
Hormones
Adiposity
Eating
Aging of materials
Growth

Keywords

  • Aging
  • Ghrelin
  • Growth hormone
  • Secretion
  • Stomach

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

Cite this

Alterations in stomach ghrelin production and in ghrelin-induced growth hormone secretion in the aged rat. / Englander, Ella; Gomez, Guillermo; Greeley, George H.

In: Mechanisms of Ageing and Development, Vol. 125, No. 12 SPEC.ISS., 12.2004, p. 871-875.

Research output: Contribution to journalArticle

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