Alterations of interferon production in a mouse model of thermal injury

Fujio Suzuki, R. B. Pollard

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The effects of thermal injury on the response of interferon (IFN) production in vivo and in vitro after stimulation with eight representative inducers was investigated in a mouse model. The response of mice to immune IFN (IFN-γ) inducers, staphylococcal enterotoxin A, concanavalin A, and a specific antigen for BCG-sensitized lymphocytes (purified protein derivative) was impaired after a 30% total body surface area third-degree burn. Suppression of IFN-γ production was observed at day 2 and persisted until day 7 after burn. Decreased IFN-γ production correlated closely with the percentage of total body surface area burned. When virus type IFN (IFN-α/β) inducers, Newcastle disease virus, polyriboinosinic-polyribocytidylic acid, 10-carboxymethyl-9-acridanone, and E. coli endotoxin, were administered to mice, no change in IFN response was observed after thermal injury. Similar results were obtained when spleen cells obtained from thermally injured mice were stimulated with IFN-γ inducers in vitro. These studies suggest that although the capacity for IFN-α/β production remains intact in thermally injured mice, IFN-γ production may be selectively decreased in burned animals and in their spleen cells.

Original languageEnglish (US)
Pages (from-to)1806-1810
Number of pages5
JournalJournal of Immunology
Volume129
Issue number5
StatePublished - 1982

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Interferons
Hot Temperature
Interferon Inducers
Wounds and Injuries
Body Surface Area
Spleen
Newcastle disease virus
Mycobacterium bovis
Concanavalin A
Endotoxins
Interferon-gamma
Lymphocytes
Escherichia coli
Viruses
Antigens
Proteins
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology

Cite this

Alterations of interferon production in a mouse model of thermal injury. / Suzuki, Fujio; Pollard, R. B.

In: Journal of Immunology, Vol. 129, No. 5, 1982, p. 1806-1810.

Research output: Contribution to journalArticle

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