Alterations of spinal dorsal horn substance P following electroacupuncture analgesia - A study of the formalin test with immunohistochemistry and densitometry

J. Du, L. He

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    Substance P (SP), released from thin afferent terminals, is believed to be a neurotransmitter for pain transmission in the spinal dorsal horn. It has been demonstrated that in addition to analgesia, morphine increases the accumulation of SP possibly due to the inhibition of its release. The present work investigated the level of spinal SP like immunoreactivity (SPLI) following electroacupuncture analgesia in rats using immunohistochemistry and image analysis. Experiment results revealed that formalin injected into the hind paw elicited marked pain response and accumulation of SP in the spinal dorsal horn. Electroacupuncture of Tsu-San-Li could depress the pain response, however increasing further the SP accumulation. It is thus suggested that pain stimulation itself may activate the endogenous opioid mechanism to inhibit SP release and acupuncture is able to enhance the process. This may be one mechanism of acupuncture analgesia.

    Original languageEnglish (US)
    Pages (from-to)1-6
    Number of pages6
    JournalAcupuncture and Electro-Therapeutics Research
    Volume17
    Issue number1
    StatePublished - 1992

    Fingerprint

    Electroacupuncture
    Densitometry
    Pain Measurement
    Substance P
    Analgesia
    Immunohistochemistry
    Pain
    Acupuncture Analgesia
    Acupuncture
    Morphine
    Opioid Analgesics
    Formaldehyde
    Neurotransmitter Agents
    Spinal Cord Dorsal Horn

    ASJC Scopus subject areas

    • Anesthesiology and Pain Medicine
    • Complementary and alternative medicine
    • Neuroscience(all)

    Cite this

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    abstract = "Substance P (SP), released from thin afferent terminals, is believed to be a neurotransmitter for pain transmission in the spinal dorsal horn. It has been demonstrated that in addition to analgesia, morphine increases the accumulation of SP possibly due to the inhibition of its release. The present work investigated the level of spinal SP like immunoreactivity (SPLI) following electroacupuncture analgesia in rats using immunohistochemistry and image analysis. Experiment results revealed that formalin injected into the hind paw elicited marked pain response and accumulation of SP in the spinal dorsal horn. Electroacupuncture of Tsu-San-Li could depress the pain response, however increasing further the SP accumulation. It is thus suggested that pain stimulation itself may activate the endogenous opioid mechanism to inhibit SP release and acupuncture is able to enhance the process. This may be one mechanism of acupuncture analgesia.",
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