Altered interleukin-6 expression in fibroblasts from hypertrophic burn scars

H. Xue, R. L. McCauley, W. Zhang, D. K. Martini

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Abstract

Hypertrophic burn scars (HBSs) are characterized by a net accumulation of collagen. The role of growth factors and various cytokines in the pathogenesis of these lesions has not been fully characterized. Interleukin-6 (IL-6) is an important immunoregulatory cytokine that can affect fibroblast function. This study showed increased expression of the IL-6 gene in fibroblasts isolated from patients with HBSs compared with control fibroblasts when the ribonuclease protection assay was used. A subsequent increase in unstimulated and stimulated IL-6 secretion was noted in HBS fibroblasts compared with normal control fibroblasts (unstimulated, 0.3627 ± 0.2017 pg/cell vs 0.0662 ± 0.0786 pg/cell, P = .0054; serum, 0.770 ± 0.523 pg/cell vs 0.233 ± 0.231 pg/cell, P = .0381; serum and interferon-γ, 0.912 ± 0.650 pg/cell and 0.244 ± 0.199 pg/cell, P = .0327). These results are further evidence of the role of inflammatory cytokines in the development of HBSs.

Original languageEnglish (US)
Pages (from-to)142-146
Number of pages5
JournalJournal of Burn Care and Rehabilitation
Volume21
Issue number2
DOIs
StatePublished - Jan 1 2000

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ASJC Scopus subject areas

  • Surgery
  • Nursing(all)
  • Emergency Medicine
  • Rehabilitation
  • Health Professions(all)

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