Altered satellite cell dynamics accompany skeletal muscle atrophy during chronic illness, disuse, and aging

Colleen F. McKenna, Christopher S. Fry

    Research output: Contribution to journalReview articlepeer-review

    14 Scopus citations

    Abstract

    Purpose of review This review explores recent research investigating the contribution of satellite cells (skeletal muscle stem cells) during muscle fiber atrophy as seen in periods of disuse, illness, and aging. Recent findings Studies indicate reduced satellite cell activity and density in a variety of acute and chronic conditions characterized by robust muscle wasting. The direct contribution of satellite cells to unloading/denervation and chronic illness-induced atrophy remains controversial. Inflammation that accompanies acute trauma and illness likely impedes proper satellite cell differentiation and myogenesis, promoting the rapid onset of muscle wasting in these conditions. Transgenic mouse studies provide surprising evidence that age-related declines in satellite cell function and abundance are not causally related to the onset of sarcopenia in sedentary animals. Summary Recent clinical and preclinical studies indicate reduced abundance and dysregulated satellite cell activity that accompany muscle atrophy during periods of disuse, illness, and aging, providing evidence for their therapeutic potential.

    Original languageEnglish (US)
    Pages (from-to)447-452
    Number of pages6
    JournalCurrent Opinion in Clinical Nutrition and Metabolic Care
    Volume20
    Issue number6
    DOIs
    StatePublished - Nov 1 2017

    Keywords

    • Pax7
    • aging
    • burn
    • cachexia
    • muscle stem cell

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Nutrition and Dietetics

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