Altered viral fitness of HIV-1 following failure of protease inhibitor-based therapy

Keyphrases

• Human Immunodeficiency Virus Type 1 (HIV-1) 100%
• Protease Inhibitors 100%
• Viral Fitness 100%
• CD4+ T 75%
• Nucleoside Reverse Transcriptase Inhibitors 50%
• Cell Count 50%
• Virological Failure 50%
• Human Peripheral Blood Lymphocytes 50%
• Severe Combined Immunodeficient Mice 50%
• T Cells 25%
• Viral Infection 25%
• CD4+ T Cells 25%
• Virus Isolate 25%
• MRNA Level 25%
• Protease 25%
• Cytopathic Effect 25%
• Ritonavir 25%
• Zidovudine 25%
• HIV Viral Load 25%
• Lamivudine 25%
• Replication Capacity 25%
• Inhibitor Resistant 25%
• Cell Depletion 25%
• Reverse Transcriptase 25%
• Resistant Virus 25%
• M184V mutation 25%

Immunology and Microbiology

• Human Immunodeficiency Virus 1 100%
• Reverse Transcriptase 100%
• T-Helper Cell 66%
• Leukocyte 66%
• SCID Mouse 66%
• CD4 Lymphocyte Count 66%
• Blood Plasma 33%
• Viral Disease 33%
• T Cell 33%
• T Cell Depletion 33%
• Cytopathic Effect 33%