Alternating therapy in major burns: Silver sulfadiazine vs. silver sulfadiazine-nitrofurazone

Robert L. McCauley, Martin C. Robson, John P. Heggers

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The use of alternating silver sulfadiazine and silver sulfadiazine-nitrofurazone, sequentially compared in 112 patients in a prospective study, proved an effective combination for treatment of major burns. The clinically undesirable side effects resulting from using either agent alone were eliminated or significantly diminished without altering the pattern of microbial isolates from the burn wound and without promoting the development of more resistant strains of Staphylococcus aureus.

Original languageEnglish (US)
Pages (from-to)384-387
Number of pages4
JournalJournal of Burn Care and Rehabilitation
Issue number5
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • General Nursing
  • Emergency Medicine
  • Rehabilitation
  • General Health Professions


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