Alternative medicine products as a novel treatment strategy for inflammatory bowel disease

Lindsey N. Jackson, Yuning Zhou, Suimin Qiu, Qingding Wang, B. Mark Evers

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Inflammatory bowel disease (IBD) affects the mucosal lining of the gastrointestinal tract; the etiology is unknown and treatment is directed at systemic immunosuppression. Natural products, including medicinal herbs, have provided approximately half of the drugs developed for clinical use over the past 20 years. The purpose of our current study was to determine the effects of a novel combination of herbal extracts on intestinal inflammation using a murine model of IBD. Female Swiss-Webster mice were randomized to receive normal water or 5% dextran sulfate sodium (DSS) drinking water to induce colitis. Mice were treated with either a novel combination of herbal aqueous extracts or vehicle control per os (po) or per rectum (pr) every 24 hours for 7-8 days. Disease activity index score (DAI) was determined daily; mice were sacrificed and colons were analyzed by H & E staining, MPO assay, and cytokine (TNF-α, IL-6) ELISAs. Mice treated with the combination of herbal extracts, either po or pr, had significantly less rectal bleeding and lower DAI scores compared to the vehicle-treated group. Moreover, colonic ulceration, leukocytic infiltration, and cytokine levels (TNF-α and IL-6) were also decreased in the colons of herbal-treated mice, reflected by H & E staining, MPO assay, and cytokine ELISA. Treatment with the combination of medicinal herbs decreases leukocyte infiltration and mucosal ulceration, ameliorating the course of acute colonic inflammation. This herbal remedy may prove to be a novel and safe therapeutic alternative in the treatment of IBD.

Original languageEnglish
Pages (from-to)953-965
Number of pages13
JournalAmerican Journal of Chinese Medicine
Volume36
Issue number5
DOIs
StatePublished - 2008

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Complementary Therapies
Inflammatory Bowel Diseases
Medicinal Plants
Cytokines
Rectum
Interleukin-6
Colon
Enzyme-Linked Immunosorbent Assay
Staining and Labeling
Inflammation
Therapeutics
Dextran Sulfate
Colitis
Biological Products
Drinking Water
Immunosuppression
Gastrointestinal Tract
Leukocytes
Hemorrhage
Water

Keywords

  • Herb
  • Inflammatory Bowel Disease
  • Natural Remedy
  • Traditional Medicine

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Alternative medicine products as a novel treatment strategy for inflammatory bowel disease. / Jackson, Lindsey N.; Zhou, Yuning; Qiu, Suimin; Wang, Qingding; Evers, B. Mark.

In: American Journal of Chinese Medicine, Vol. 36, No. 5, 2008, p. 953-965.

Research output: Contribution to journalArticle

Jackson, Lindsey N. ; Zhou, Yuning ; Qiu, Suimin ; Wang, Qingding ; Evers, B. Mark. / Alternative medicine products as a novel treatment strategy for inflammatory bowel disease. In: American Journal of Chinese Medicine. 2008 ; Vol. 36, No. 5. pp. 953-965.
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