Alzheimer's disease - A dysfunction in cholesterol and lipid metabolism

Walter J. Lukiw, Miguel Pappolla, Ricardo Palacios Pelaez, Nicolas G. Bazan

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

1. Strong etiological association exists between dysfunctional metabolism of brain lipids, age-related changes in the cerebral vasculature and neurodegenerative features characteristic of Alzheimer's disease (AD) brain. 2. In this short review, recent experimental evidence for these associations is further discussed below.

Original languageEnglish (US)
Pages (from-to)475-483
Number of pages9
JournalCellular and Molecular Neurobiology
Volume25
Issue number3-4
DOIs
StatePublished - Jun 2005
Externally publishedYes

Fingerprint

Lipid Metabolism
Brain
Alzheimer Disease
Cholesterol
Metabolism
Lipids

Keywords

  • Alzheimer
  • Amyloid
  • Cholesterol
  • Lipids
  • Oxidation
  • Statins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Biochemistry
  • Cell Biology
  • Genetics

Cite this

Alzheimer's disease - A dysfunction in cholesterol and lipid metabolism. / Lukiw, Walter J.; Pappolla, Miguel; Pelaez, Ricardo Palacios; Bazan, Nicolas G.

In: Cellular and Molecular Neurobiology, Vol. 25, No. 3-4, 06.2005, p. 475-483.

Research output: Contribution to journalArticle

Lukiw, Walter J. ; Pappolla, Miguel ; Pelaez, Ricardo Palacios ; Bazan, Nicolas G. / Alzheimer's disease - A dysfunction in cholesterol and lipid metabolism. In: Cellular and Molecular Neurobiology. 2005 ; Vol. 25, No. 3-4. pp. 475-483.
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