Alzheimer's disease - A dysfunction in cholesterol and lipid metabolism

Walter J. Lukiw, Miguel Pappolla, Ricardo Palacios Pelaez, Nicolas G. Bazan

Research output: Contribution to journalReview article

33 Scopus citations

Abstract

1. Strong etiological association exists between dysfunctional metabolism of brain lipids, age-related changes in the cerebral vasculature and neurodegenerative features characteristic of Alzheimer's disease (AD) brain. 2. In this short review, recent experimental evidence for these associations is further discussed below.

Original languageEnglish (US)
Pages (from-to)475-483
Number of pages9
JournalCellular and Molecular Neurobiology
Volume25
Issue number3-4
DOIs
StatePublished - Jun 1 2005
Externally publishedYes

Keywords

  • Alzheimer
  • Amyloid
  • Cholesterol
  • Lipids
  • Oxidation
  • Statins

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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