Alzheimer's disease - A dysfunction in cholesterol and lipid metabolism

Walter J. Lukiw; Miguel Pappolla; Ricardo Palacios Pelaez; Nicolas G. Bazan

doi:10.1007/s10571-005-4010-6

Alzheimer's disease - A dysfunction in cholesterol and lipid metabolism

Walter J. Lukiw, Miguel Pappolla, Ricardo Palacios Pelaez, Nicolas G. Bazan

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

1. Strong etiological association exists between dysfunctional metabolism of brain lipids, age-related changes in the cerebral vasculature and neurodegenerative features characteristic of Alzheimer's disease (AD) brain. 2. In this short review, recent experimental evidence for these associations is further discussed below.

Original language	English (US)
Pages (from-to)	475-483
Number of pages	9
Journal	Cellular and Molecular Neurobiology
Volume	25
Issue number	3-4
DOIs	https://doi.org/10.1007/s10571-005-4010-6
State	Published - Jun 2005
Externally published	Yes

Keywords

Alzheimer
Amyloid
Cholesterol
Lipids
Oxidation
Statins

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Cell Biology

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10.1007/s10571-005-4010-6

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title = "Alzheimer's disease - A dysfunction in cholesterol and lipid metabolism",

abstract = "1. Strong etiological association exists between dysfunctional metabolism of brain lipids, age-related changes in the cerebral vasculature and neurodegenerative features characteristic of Alzheimer's disease (AD) brain. 2. In this short review, recent experimental evidence for these associations is further discussed below.",

keywords = "Alzheimer, Amyloid, Cholesterol, Lipids, Oxidation, Statins",

author = "Lukiw, {Walter J.} and Miguel Pappolla and Pelaez, {Ricardo Palacios} and Bazan, {Nicolas G.}",

note = "Funding Information: Supported in part by NIH NIA AG18031.",

year = "2005",

month = jun,

doi = "10.1007/s10571-005-4010-6",

language = "English (US)",

volume = "25",

pages = "475--483",

journal = "Cellular and Molecular Neurobiology",

issn = "0272-4340",

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number = "3-4",

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TY - JOUR

T1 - Alzheimer's disease - A dysfunction in cholesterol and lipid metabolism

AU - Lukiw, Walter J.

AU - Pappolla, Miguel

AU - Pelaez, Ricardo Palacios

AU - Bazan, Nicolas G.

N1 - Funding Information: Supported in part by NIH NIA AG18031.

PY - 2005/6

Y1 - 2005/6

N2 - 1. Strong etiological association exists between dysfunctional metabolism of brain lipids, age-related changes in the cerebral vasculature and neurodegenerative features characteristic of Alzheimer's disease (AD) brain. 2. In this short review, recent experimental evidence for these associations is further discussed below.

AB - 1. Strong etiological association exists between dysfunctional metabolism of brain lipids, age-related changes in the cerebral vasculature and neurodegenerative features characteristic of Alzheimer's disease (AD) brain. 2. In this short review, recent experimental evidence for these associations is further discussed below.

KW - Alzheimer

KW - Amyloid

KW - Cholesterol

KW - Lipids

KW - Oxidation

KW - Statins

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U2 - 10.1007/s10571-005-4010-6

DO - 10.1007/s10571-005-4010-6

M3 - Review article

C2 - 16075376

AN - SCOPUS:23944501334

SN - 0272-4340

VL - 25

SP - 475

EP - 483

JO - Cellular and Molecular Neurobiology

JF - Cellular and Molecular Neurobiology

IS - 3-4

ER -

Alzheimer's disease - A dysfunction in cholesterol and lipid metabolism

Abstract

Keywords

ASJC Scopus subject areas

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