Amicoumacin antibiotic production and genetic diversity of Bacillus subtilis strains isolated from different habitats

Iryna Pinchuk, Philippe Bressollier, Irina B. Sorokulova, Bernard Verneuil, Maria C. Urdaci

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

One of the most interesting groups of phenolic compounds is comprised of the low molecular weight phenylpropanol derivative substances named isocoumarins, which possess important biological activities. In this study, the isocoumarin production and genetic diversity of 51 Bacillus strains isolated from different geographical and ecological niches were studied. Using molecular identification techniques, 47 strains were identified as B. subtilis, three as B. licheniformis and one as B. pumilus. When these strains were screened for isocumarin production, 11 belonging to the species B. subtilis produced amicoumacins, antibiotics of the isocoumarin group. RAPD analysis demonstrated that these strains fell into two groups which contained only these amicoumacin producers. No association was detected between RAPD profiles and the geographic origin or habitat of the strains tested. In conclusion, production of amicoumacin antibiotics by B. subtilis is a common characteristic of individual strains that presented genetic and physiological homogeneity.

Original languageEnglish (US)
Pages (from-to)269-276
Number of pages8
JournalResearch in Microbiology
Volume153
Issue number5
DOIs
StatePublished - 2002
Externally publishedYes

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Isocoumarins
Bacillus subtilis
Ecosystem
Anti-Bacterial Agents
Bacillus
Molecular Weight

Keywords

  • Amicoumacins
  • Antibiotics
  • Bacillus subtilis
  • Isocoumarins
  • RAPD

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology

Cite this

Amicoumacin antibiotic production and genetic diversity of Bacillus subtilis strains isolated from different habitats. / Pinchuk, Iryna; Bressollier, Philippe; Sorokulova, Irina B.; Verneuil, Bernard; Urdaci, Maria C.

In: Research in Microbiology, Vol. 153, No. 5, 2002, p. 269-276.

Research output: Contribution to journalArticle

Pinchuk, Iryna ; Bressollier, Philippe ; Sorokulova, Irina B. ; Verneuil, Bernard ; Urdaci, Maria C. / Amicoumacin antibiotic production and genetic diversity of Bacillus subtilis strains isolated from different habitats. In: Research in Microbiology. 2002 ; Vol. 153, No. 5. pp. 269-276.
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