Amidines are potent inhibitors of nitric oxide synthases: preferential inhibition of the inducible isoform

Keyphrases

• Nitric Oxide Synthase Inhibitors 100%
• Potent Inhibitor 100%
• Amidines 100%
• Arginine 80%
• EC50 60%
• Inducible Nitric Oxide Synthase 40%
• Endothelial Nitric Oxide Synthase (eNOS) 40%
• Methyl 40%
• Rank Order 40%
• Citrulline 20%
• Nitric Oxide Synthase Isoforms 20%
• Nω-nitro-L-arginine 20%
• Anesthetized Rats 20%
• Alkyl 20%
• Human Aortic Endothelial Cells 20%
• J774 Macrophages 20%
• Nitrite Formation 20%
• Pressor Effect 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Nitric Oxide Synthase 100%
• Arginine 100%
• Amidinium 100%
• EC50 60%
• Endothelial Nitric Oxide Synthase 40%
• Inducible Nitric Oxide Synthase 20%
• Nitric Oxide Synthase Inhibitor 20%
• Nitrite 20%
• Citrulline 20%

Biochemistry, Genetics and Molecular Biology

• Isoform 100%
• Nitric Oxide Synthase 100%
• Arginine 71%
• EC50 42%
• Ordo 28%
• Macrophage 14%
• Cell-Free System 14%
• Pressor Response 14%
• Citrulline 14%