Amniotic fluid interleukin-1β and interleukin-8 concentrations: Racial disparity in preterm birth

Ramkumar Menon, Scott M. Williams, Stephen J. Fortunato

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The purpose of this study is to examine the racial differences between interleukin (IL)-1β and IL-8 concentrations in the amniotic fluid of black and white women with spontaneous preterm birth (PTB). In this study, 350 amniotic fluid samples were collected: 165 PTB cases (<36 weeks' gestation; 52 blacks and 113 whites) and 185 controls (normal term delivery >37 weeks' gestation; 87 blacks and 98 whites). Amniotic fluid IL-1β and IL-8 concentrations were measured by immunoassay. Wilcoxon nonparametric test was performed for statistical analysis. In data stratified by race, the median IL-1β concentration was significantly higher in black cases (80 pg/mL) compared to black controls (23.7 pg/mL; P <.0001), and the difference was nonsignificant in white cases (25.5 pg/mL) compared to white controls (21.3 pg/mL; P =.1). IL-8 concentration was not higher in black cases (742.2 pg/mL) compared to black controls (731.4 pg/mL; P =.9), whereas it was higher in white cases (1362.3 pg/mL) compared to white controls (533.5 pg/mL; P =.0005). Between races, IL-1β was significantly higher in blacks (P <.0001) than in whites in PTB, whereas no significant difference was noticed in IL-8 concentration between races (P =.1). In PTB, the cytokine footprint differs in the amniotic fluid between racial groups. IL-1β is higher in black and IL-8 in white PTB. These differences in the amniotic fluid cytokine concentration might not explain the racial disparity in the PTB rate, but they are suggestive of different processes of PTB in whites and blacks.

Original languageEnglish (US)
Pages (from-to)253-259
Number of pages7
JournalReproductive Sciences
Volume14
Issue number3
DOIs
StatePublished - Apr 2007
Externally publishedYes

Fingerprint

Premature Birth
Amniotic Fluid
Interleukin-8
Interleukin-1
Cytokines
Birth Rate
Immunoassay
Pregnancy
hydroquinone

Keywords

  • Cytokines
  • Ethnicity
  • Inflammation
  • Prematurity
  • Preterm labor
  • Rate

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Amniotic fluid interleukin-1β and interleukin-8 concentrations : Racial disparity in preterm birth. / Menon, Ramkumar; Williams, Scott M.; Fortunato, Stephen J.

In: Reproductive Sciences, Vol. 14, No. 3, 04.2007, p. 253-259.

Research output: Contribution to journalArticle

Menon, Ramkumar ; Williams, Scott M. ; Fortunato, Stephen J. / Amniotic fluid interleukin-1β and interleukin-8 concentrations : Racial disparity in preterm birth. In: Reproductive Sciences. 2007 ; Vol. 14, No. 3. pp. 253-259.
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