Amniotic fluid myeloperoxidase in pregnancies complicated by preterm prelabor rupture of membranes

Marian Kacerovsky, Vojtech Tambor, Marie Vajrychová, Juraj Lenco, Helena Hornychova, Ivana Musilova, Ramkumar Menon

    Research output: Contribution to journalArticlepeer-review

    5 Scopus citations

    Abstract

    Objective: To determine amniotic fluid myeloperoxidase concentration in women with preterm prelabor rupture of the membranes with microbial invasion of the amniotic cavity and histological chorioamnionitis. Methods: One hundred eighty-one women with singleton pregnancies with a gestational age between 24+0 and 36+6 weeks were included in this study. Amniocenteses were performed, and myeloperoxidase concentration in the amniotic fluid was determined using ELISA. Result: Women with microbial invasion of the amniotic cavity had higher median myeloperoxidase concentration than women without this condition (149.2ng/mL vs. 54.6ng/mL; p = 0.0006). Women with the presence of histological chorioamnionitis had higher median myeloperoxidase concentration than women without histological chorioamnionitis (103.7ng/mL vs. 50.0ng/mL; p = 0.0001). The presence of both microbial invasion of the amniotic cavity and histological chorioamnionitis was associated with higher median myeloperoxidase concentration (456.0ng/mL vs. 52.9ng/mL; p < 0.0001). The results remained significant after adjusting for gestational age. Conclusions: Increased amniotic fluid myeloperoxidase in microbial invasion of the amniotic cavity and histological chorioamnionitis confirm a role of myeloperoxidase in preterm prelabor rupture of the membranes pathophysiology.

    Original languageEnglish (US)
    Pages (from-to)463-468
    Number of pages6
    JournalJournal of Maternal-Fetal and Neonatal Medicine
    Volume26
    Issue number5
    DOIs
    StatePublished - Mar 2013

    Keywords

    • Histological chorioamnionitis
    • Lysosomal protein
    • Microbial invasion of the amniotic cavity
    • Neonatal outcome
    • Preterm delivery

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health
    • Obstetrics and Gynecology

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