Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease

Marcos J. Guerrero-Muñoz, Diana L. Castillo-Carranza, Shashirekha Krishnamurthy, Adriana A. Paulucci-Holthauzen, Urmi Sengupta, Cristian A. Lasagna-Reeves, Yembur Ahmad, George R. Jackson, Rakez Kayed

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Alzheimer's disease is a complex disease characterized by overlapping phenotypes with different neurodegenerative disorders. Oligomers are considered the most toxic species in amyloid pathologies. We examined human AD brain samples using an anti-oligomer antibody generated in our laboratory and detected potential hybrid oligomers composed of amyloid-β, prion protein, α-synuclein, and TDP-43 phosphorylated at serines 409 and 410. These data and in vitro results suggest that Aβ oligomer seeds act as a template for the aggregation of other proteins and generate an overlapping phenotype with other neuronal disorders. Furthermore, these results could explain why anti-amyloid-β therapy has been unsuccessful.

Original languageEnglish (US)
Pages (from-to)14-23
Number of pages10
JournalNeurobiology of Disease
Volume71
DOIs
StatePublished - 2014

Fingerprint

Amyloidosis
Amyloid
Alzheimer Disease
Synucleins
Phenotype
Amyloidogenic Proteins
Poisons
Neurodegenerative Diseases
Serine
Anti-Idiotypic Antibodies
Seeds
Pathology
Brain
Proteins
Therapeutics
In Vitro Techniques
Prion Proteins

Keywords

  • Alzheimer's disease
  • Aβ oligomers and cross seeding
  • Mixed proteinopathy
  • Protein aggregation

ASJC Scopus subject areas

  • Neurology

Cite this

Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Krishnamurthy, S., Paulucci-Holthauzen, A. A., Sengupta, U., Lasagna-Reeves, C. A., ... Kayed, R. (2014). Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease. Neurobiology of Disease, 71, 14-23. https://doi.org/10.1016/j.nbd.2014.08.008

Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease. / Guerrero-Muñoz, Marcos J.; Castillo-Carranza, Diana L.; Krishnamurthy, Shashirekha; Paulucci-Holthauzen, Adriana A.; Sengupta, Urmi; Lasagna-Reeves, Cristian A.; Ahmad, Yembur; Jackson, George R.; Kayed, Rakez.

In: Neurobiology of Disease, Vol. 71, 2014, p. 14-23.

Research output: Contribution to journalArticle

Guerrero-Muñoz, MJ, Castillo-Carranza, DL, Krishnamurthy, S, Paulucci-Holthauzen, AA, Sengupta, U, Lasagna-Reeves, CA, Ahmad, Y, Jackson, GR & Kayed, R 2014, 'Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease', Neurobiology of Disease, vol. 71, pp. 14-23. https://doi.org/10.1016/j.nbd.2014.08.008
Guerrero-Muñoz MJ, Castillo-Carranza DL, Krishnamurthy S, Paulucci-Holthauzen AA, Sengupta U, Lasagna-Reeves CA et al. Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease. Neurobiology of Disease. 2014;71:14-23. https://doi.org/10.1016/j.nbd.2014.08.008
Guerrero-Muñoz, Marcos J. ; Castillo-Carranza, Diana L. ; Krishnamurthy, Shashirekha ; Paulucci-Holthauzen, Adriana A. ; Sengupta, Urmi ; Lasagna-Reeves, Cristian A. ; Ahmad, Yembur ; Jackson, George R. ; Kayed, Rakez. / Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease. In: Neurobiology of Disease. 2014 ; Vol. 71. pp. 14-23.
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