Amyrisins A-C, O -prenylated flavonoids from amyris madrensis

Jiangnan Peng, Rachel M. Hartley, Gary A. Fest, Susan L. Mooberry

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Three new O-prenylated flavonoids, amyrisins A-C (1-3), were isolated from the leaves and twigs of Amyris madrensis, along with the known compound polygamain (4). The structures of 1-3 were elucidated on the basis of the analysis of spectroscopic data interpretation. Amyrisins B (2) and C (3) showed moderate cytotoxicity against PC-3 and DU 145 prostate cancer cells with IC 50 values of 17.5 and 23 μM, respectively, while amyrisin A (1) did not show any cytotoxicity at the highest concentration tested, 50 μM. Polygamain (4) exhibited potent antiproliferative and microtubule-depolymerizing activities.

Original languageEnglish (US)
Pages (from-to)494-496
Number of pages3
JournalJournal of Natural Products
Volume75
Issue number3
DOIs
StatePublished - Mar 23 2012

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Peng, J., Hartley, R. M., Fest, G. A., & Mooberry, S. L. (2012). Amyrisins A-C, O -prenylated flavonoids from amyris madrensis. Journal of Natural Products, 75(3), 494-496. https://doi.org/10.1021/np200796e