Amyrisins A-C, O -prenylated flavonoids from amyris madrensis

Jiangnan Peng, Rachel M. Hartley, Gary A. Fest, Susan L. Mooberry

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Three new O-prenylated flavonoids, amyrisins A-C (1-3), were isolated from the leaves and twigs of Amyris madrensis, along with the known compound polygamain (4). The structures of 1-3 were elucidated on the basis of the analysis of spectroscopic data interpretation. Amyrisins B (2) and C (3) showed moderate cytotoxicity against PC-3 and DU 145 prostate cancer cells with IC 50 values of 17.5 and 23 μM, respectively, while amyrisin A (1) did not show any cytotoxicity at the highest concentration tested, 50 μM. Polygamain (4) exhibited potent antiproliferative and microtubule-depolymerizing activities.

Original languageEnglish (US)
Pages (from-to)494-496
Number of pages3
JournalJournal of Natural Products
Volume75
Issue number3
DOIs
StatePublished - Mar 23 2012
Externally publishedYes

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Cytotoxicity
Flavonoids
Microtubules
Prostatic Neoplasms
Cells
polygamain
amyrisin A
amyrisin C
amyrisin B

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Peng, J., Hartley, R. M., Fest, G. A., & Mooberry, S. L. (2012). Amyrisins A-C, O -prenylated flavonoids from amyris madrensis. Journal of Natural Products, 75(3), 494-496. https://doi.org/10.1021/np200796e

Amyrisins A-C, O -prenylated flavonoids from amyris madrensis. / Peng, Jiangnan; Hartley, Rachel M.; Fest, Gary A.; Mooberry, Susan L.

In: Journal of Natural Products, Vol. 75, No. 3, 23.03.2012, p. 494-496.

Research output: Contribution to journalArticle

Peng, J, Hartley, RM, Fest, GA & Mooberry, SL 2012, 'Amyrisins A-C, O -prenylated flavonoids from amyris madrensis', Journal of Natural Products, vol. 75, no. 3, pp. 494-496. https://doi.org/10.1021/np200796e
Peng, Jiangnan ; Hartley, Rachel M. ; Fest, Gary A. ; Mooberry, Susan L. / Amyrisins A-C, O -prenylated flavonoids from amyris madrensis. In: Journal of Natural Products. 2012 ; Vol. 75, No. 3. pp. 494-496.
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