An ACTH Receptor on Human Mononuclear Leukocytes

Eric M. Smith, Pat Brosnan, Walter J. Meyer, J. Edwin Blalock

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Abstract

THE inaccessibility of many tissues makes routine investigation for receptor defects impossible. ACTH insensitivity syndrome, first described by Shepard et al.1 in 1959 and now reported in more than 63 patients,1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 is an example of this problem. Defects in adrenal ACTH receptors have been postulated because of high circulating ACTH levels and the ability of the adrenal-cortex cells to achieve steroidogenesis through an elevation of cyclic AMP.1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 In the majority of cases, the clinical presentation includes hyperpigmentation, hypoglycemia, and extremely low glucocorticoid levels with normal mineralocorticoid concentrations.2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Differences between cases suggest that the syndrome may have multiple causes. Adrenal cells…

Original languageEnglish (US)
Pages (from-to)1266-1269
Number of pages4
JournalNew England Journal of Medicine
Volume317
Issue number20
DOIs
StatePublished - Nov 12 1987

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  • Medicine(all)

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Smith, E. M., Brosnan, P., Meyer, W. J., & Blalock, J. E. (1987). An ACTH Receptor on Human Mononuclear Leukocytes. New England Journal of Medicine, 317(20), 1266-1269. https://doi.org/10.1056/NEJM198711123172006