An allergen portrait gallery: Representative structures and an overview of IgE binding surfaces

Catherine H. Schein, Ovidiu Ivanciuc, Terumi Midoro-Horiuti, Randall M. Goldblum, Werner Braun

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Recent progress in the biochemical classification and structural determination of allergens and allergen-antibody complexes has enhanced our understanding of the molecular determinants of allergenicity. Databases of allergens and their epitopes have facilitated the clustering of allergens according to their sequences and, more recently, their structures. Groups of similar sequences are identified for allergenic proteins from diverse sources, and all allergens are classified into a limited number of protein structural families. A gallery of experimental structures selected from the protein classes with the largest number of allergens demonstrate the structural diversity of the allergen universe. Further comparison of these structures and identification of areas that are different from innocuous proteins within the same protein family can be used to identify features specific to known allergens. Experimental and computational results related to the determination of IgE binding surfaces and methods to define allergen-specific motifs are highlighted.

Original languageEnglish (US)
Pages (from-to)113-125
Number of pages13
JournalBioinformatics and Biology Insights
Volume4
StatePublished - 2010

Fingerprint

Allergens
Immunoglobulin E
Protein
Proteins
Antibody
Computational Results
Determinant
Epitopes
Clustering
Experimental Results
Antibodies
Cluster Analysis
Demonstrate
Databases

Keywords

  • Allergen PFAM classification
  • Allergen specific motifs
  • Cross-reactiviy
  • IgE epitopes
  • Specific immunotherapy
  • Structural database of allergenic proteins

ASJC Scopus subject areas

  • Computer Science Applications
  • Biochemistry
  • Molecular Biology
  • Applied Mathematics
  • Computational Mathematics

Cite this

An allergen portrait gallery : Representative structures and an overview of IgE binding surfaces. / Schein, Catherine H.; Ivanciuc, Ovidiu; Midoro-Horiuti, Terumi; Goldblum, Randall M.; Braun, Werner.

In: Bioinformatics and Biology Insights, Vol. 4, 2010, p. 113-125.

Research output: Contribution to journalArticle

@article{9a7f89b5fd1040b3a2ca45427dea7cf1,
title = "An allergen portrait gallery: Representative structures and an overview of IgE binding surfaces",
abstract = "Recent progress in the biochemical classification and structural determination of allergens and allergen-antibody complexes has enhanced our understanding of the molecular determinants of allergenicity. Databases of allergens and their epitopes have facilitated the clustering of allergens according to their sequences and, more recently, their structures. Groups of similar sequences are identified for allergenic proteins from diverse sources, and all allergens are classified into a limited number of protein structural families. A gallery of experimental structures selected from the protein classes with the largest number of allergens demonstrate the structural diversity of the allergen universe. Further comparison of these structures and identification of areas that are different from innocuous proteins within the same protein family can be used to identify features specific to known allergens. Experimental and computational results related to the determination of IgE binding surfaces and methods to define allergen-specific motifs are highlighted.",
keywords = "Allergen PFAM classification, Allergen specific motifs, Cross-reactiviy, IgE epitopes, Specific immunotherapy, Structural database of allergenic proteins",
author = "Schein, {Catherine H.} and Ovidiu Ivanciuc and Terumi Midoro-Horiuti and Goldblum, {Randall M.} and Werner Braun",
year = "2010",
language = "English (US)",
volume = "4",
pages = "113--125",
journal = "Bioinformatics and Biology Insights",
issn = "1177-9322",
publisher = "Libertas Academica Ltd.",

}

TY - JOUR

T1 - An allergen portrait gallery

T2 - Representative structures and an overview of IgE binding surfaces

AU - Schein, Catherine H.

AU - Ivanciuc, Ovidiu

AU - Midoro-Horiuti, Terumi

AU - Goldblum, Randall M.

AU - Braun, Werner

PY - 2010

Y1 - 2010

N2 - Recent progress in the biochemical classification and structural determination of allergens and allergen-antibody complexes has enhanced our understanding of the molecular determinants of allergenicity. Databases of allergens and their epitopes have facilitated the clustering of allergens according to their sequences and, more recently, their structures. Groups of similar sequences are identified for allergenic proteins from diverse sources, and all allergens are classified into a limited number of protein structural families. A gallery of experimental structures selected from the protein classes with the largest number of allergens demonstrate the structural diversity of the allergen universe. Further comparison of these structures and identification of areas that are different from innocuous proteins within the same protein family can be used to identify features specific to known allergens. Experimental and computational results related to the determination of IgE binding surfaces and methods to define allergen-specific motifs are highlighted.

AB - Recent progress in the biochemical classification and structural determination of allergens and allergen-antibody complexes has enhanced our understanding of the molecular determinants of allergenicity. Databases of allergens and their epitopes have facilitated the clustering of allergens according to their sequences and, more recently, their structures. Groups of similar sequences are identified for allergenic proteins from diverse sources, and all allergens are classified into a limited number of protein structural families. A gallery of experimental structures selected from the protein classes with the largest number of allergens demonstrate the structural diversity of the allergen universe. Further comparison of these structures and identification of areas that are different from innocuous proteins within the same protein family can be used to identify features specific to known allergens. Experimental and computational results related to the determination of IgE binding surfaces and methods to define allergen-specific motifs are highlighted.

KW - Allergen PFAM classification

KW - Allergen specific motifs

KW - Cross-reactiviy

KW - IgE epitopes

KW - Specific immunotherapy

KW - Structural database of allergenic proteins

UR - http://www.scopus.com/inward/record.url?scp=78650000581&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650000581&partnerID=8YFLogxK

M3 - Article

C2 - 20981266

AN - SCOPUS:78650000581

VL - 4

SP - 113

EP - 125

JO - Bioinformatics and Biology Insights

JF - Bioinformatics and Biology Insights

SN - 1177-9322

ER -