TY - JOUR
T1 - An embryonic heart cell line is susceptible to dengue virus infection
AU - Angel-Ambrocio, Antonio H.
AU - Soto-Acosta, Rubén
AU - Tammineni, Eshwar R.
AU - Carrillo, Elba D.
AU - Bautista-Carbajal, Patricia
AU - Hernández, Ascención
AU - Sánchez, Jorge A.
AU - del Angel, Rosa M.
N1 - Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015/2/16
Y1 - 2015/2/16
N2 - Dengue virus (DENV) is the causative agent of dengue fever. In recent years, patients with more severe form of the disease with acute heart failure or progression to cardiogenic shock and death have been reported. However, the pathogenesis of myocardial lesions and susceptibility of cardiomyocytes to DENV infection have not been evaluated. Under this perspective, the susceptibility of the myoblast cell line H9c2, obtained from embryonic rat heart, to DENV infection was analyzed. Our findings indicate that H9c2 cells are susceptible to the infection with the four DENV serotypes. Moreover, virus translation/replication and viral production in this cell line is as efficient as in other susceptible cell lines, supporting the idea that DENV may target heart cells as evidenced by infection of H9c2 cells. This cell line may thus represent an excellent model for the study and characterization of cardiac physiopathology in DENV infection.
AB - Dengue virus (DENV) is the causative agent of dengue fever. In recent years, patients with more severe form of the disease with acute heart failure or progression to cardiogenic shock and death have been reported. However, the pathogenesis of myocardial lesions and susceptibility of cardiomyocytes to DENV infection have not been evaluated. Under this perspective, the susceptibility of the myoblast cell line H9c2, obtained from embryonic rat heart, to DENV infection was analyzed. Our findings indicate that H9c2 cells are susceptible to the infection with the four DENV serotypes. Moreover, virus translation/replication and viral production in this cell line is as efficient as in other susceptible cell lines, supporting the idea that DENV may target heart cells as evidenced by infection of H9c2 cells. This cell line may thus represent an excellent model for the study and characterization of cardiac physiopathology in DENV infection.
KW - Cardiomyocytes
KW - Dengue
KW - H9c2 cells
KW - Infection
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U2 - 10.1016/j.virusres.2015.01.004
DO - 10.1016/j.virusres.2015.01.004
M3 - Article
C2 - 25598317
AN - SCOPUS:84922987973
SN - 0168-1702
VL - 198
SP - 53
EP - 58
JO - Virus Research
JF - Virus Research
ER -