An emerging hemorrhagic fever in China caused by a novel bunyavirus SFTSV

Xiao Shuang Zhang, Yan Liu, Li Zhao, Bing Li, Hao Yu, Hong Ling Wen, Xue Jie Yu

Research output: Contribution to journalReview article

48 Scopus citations

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever in rural areas of China and is caused by a new bunyavirus, SFTSV, named after the disease. The transmission vectors and animal hosts of SFTSV are unclear. Ticks are the most likely transmission vectors and domestic animals, including goats, dogs, and cattle, are potential amplifying hosts of SFTSV. The clinical symptoms of SFTS are nonspecific, but major symptoms include fever, gastrointestinal symptoms, myalgia, dizziness, joint pain, chills, and regional lymphadenopathy. The most common abnormalities in laboratory test results are thrombocytopenia (95%), leukocytopenia (86%), and elevated levels of serum alanine aminotransferase, aspartate aminotransferase, creatine kinase, and lactate dehydrogenase. The fatality rate for SFTS is 12% on average, and the annual incidence of the disease is approximately five per 100000 of the rural population.

Original languageEnglish (US)
Pages (from-to)697-700
Number of pages4
JournalScience China Life Sciences
Volume56
Issue number8
DOIs
StatePublished - Aug 1 2013

Keywords

  • Phlebovirus
  • SFTSV
  • bunyavirus
  • emerging infectious diseases
  • hemorrhagic fever
  • leukopenia
  • thrombocytopenia
  • tick

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

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  • Cite this

    Zhang, X. S., Liu, Y., Zhao, L., Li, B., Yu, H., Wen, H. L., & Yu, X. J. (2013). An emerging hemorrhagic fever in China caused by a novel bunyavirus SFTSV. Science China Life Sciences, 56(8), 697-700. https://doi.org/10.1007/s11427-013-4518-9