@article{32c58d267d494c45bf90837b38523648,
title = "An environmentally benign regioselective synthesis of 2-benzyl-4-arylquinoline derivatives using aryl amines, styrene oxides and aryl acetylenes",
abstract = "A novel and an expedient metal- and solvent-free synthesis of a wide variety of 2-benzyl-4-arylquinoline derivatives is described from readily available aryl amines, styrene oxides and aryl acetylenes in the presence of 10 mol% molecular iodine. This domino reaction occurs under metal- and solvent-free conditions at 120 °C, which avoids the usage of metal catalyst and as a consequence generation of metal waste. The salient features of this methodology are the use of simple starting materials, ease of handling, high regioselectivity, shorter reaction time, atom-economical, step-economical, the formation of one C-N and two C-C bonds and a wide range of functional groups tolerance.",
author = "Saghir Ali and Khan, {Abu T.}",
note = "Funding Information: SA is thankful to IIT Guwahati for his research fellowship. We are also grateful to Centre Instrument Facility (CIF), IIT Guwahati for instrument facilities. The Department of Science and Technology, New Delhi is highly acknowledged for financial support (Research Grant No. CRG/2018/002120/OC) to Professor A. T. Khan. We also grateful to MHRD for 400 MHz NMR facility under COE-FAST programme (Sanction No. 5-5/ 2014-TS VII) and DST for providing 500 MHz NMR under DST-FIST programme (Sanction No. SR/FST/CS-II/2017/23C). We are also thankful to the Editor for critical evaluation as well as both the Referees{\textquoteright} for their valuable comments and suggestions to improve further the quality of our manuscript. Funding Information: SA is thankful to IIT Guwahati for his research fellowship. We are also grateful to Centre Instrument Facility (CIF), IIT Guwahati for instrument facilities. The Department of Science and Technology, New Delhi is highly acknowledged for financial support (Research Grant No. CRG/2018/002120/OC) to Professor A. T. Khan. We also grateful to MHRD for 400 MHz NMR facility under COE-FAST programme (Sanction No. 5-5/2014-TS VII) and DST for providing 500 MHz NMR under DST-FIST programme (Sanction No. SR/FST/CS-II/2017/23C). We are also thankful to the Editor for critical evaluation as well as both the Referees? for their valuable comments and suggestions to improve further the quality of our manuscript. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2021.",
year = "2021",
month = oct,
day = "28",
doi = "10.1039/d1ob01699g",
language = "English (US)",
volume = "19",
pages = "8772--8782",
journal = "Organic and Biomolecular Chemistry",
issn = "1477-0520",
publisher = "Royal Society of Chemistry",
number = "40",
}