An environmentally benign regioselective synthesis of 2-benzyl-4-arylquinoline derivatives using aryl amines, styrene oxides and aryl acetylenes

Saghir Ali, Abu T. Khan

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A novel and an expedient metal- and solvent-free synthesis of a wide variety of 2-benzyl-4-arylquinoline derivatives is described from readily available aryl amines, styrene oxides and aryl acetylenes in the presence of 10 mol% molecular iodine. This domino reaction occurs under metal- and solvent-free conditions at 120 °C, which avoids the usage of metal catalyst and as a consequence generation of metal waste. The salient features of this methodology are the use of simple starting materials, ease of handling, high regioselectivity, shorter reaction time, atom-economical, step-economical, the formation of one C-N and two C-C bonds and a wide range of functional groups tolerance.

Original languageEnglish (US)
Pages (from-to)8772-8782
Number of pages11
JournalOrganic and Biomolecular Chemistry
Volume19
Issue number40
DOIs
StatePublished - Oct 28 2021
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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