An experimental study on the effect of praziquantel and oltipraz on some lysosomal enzymes

A. El-Sharkawy, M. El-Toukhy, S. Z. Abdel-Rahman, Z. El-Kholy, H. Farag, S. El-Zoghby, N. Gaber

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The in-vivo effect of the schistosomicidal drugs praziquantel and oltipraz on the activities of the liver lysosomal enzymes in Schistosoma mansoni-infected and non-infected mice was studied. The effect of S. mansoni infection and the administration of the schistosomicidal drugs on the activities of β-glucuronidase, acid ribonuclease and α-naphthyl acetate esterases may be considered as indices for carcinogenicity. Drugs were given orally in subcurative doses, either in a single dose of 400 mg kg-1 for praziquantel or in five daily doses of 50 mg kg-1 oltipraz. The increase in enzymatic activities in infected animals was attributed to deranged metabolic function as a result of liver cell injury. Treatment of uninfected animals with either praziquantel or oltipraz significantly increased the activities of the three Iysosomal enzymes. Praziquantel possesses reversible and less toxic effects on the liver than oltipraz. The role of these antischistosomal drugs cannot be ignored as a possible aetiological factor implicated in the process of carcinogenesis associated with schistosomiasis infection through modulation of the operating potential of the enzymes concerned with detoxification, protein and fat metabolism.

Original languageEnglish (US)
Pages (from-to)28-34
Number of pages7
JournalJournal of Tropical Medicine and Hygiene
Volume96
Issue number1
StatePublished - Jan 1 1993
Externally publishedYes

Keywords

  • Lysosomal enzymes
  • Oltipraz
  • Praziquantel
  • Schistosoma mansoni infection

ASJC Scopus subject areas

  • Parasitology
  • Environmental Science(all)
  • Engineering(all)
  • Infectious Diseases
  • Earth and Planetary Sciences(all)

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