An experimental study on the effect of praziquantel and oltipraz on some lysosomal enzymes

A. El-Sharkawy, M. El-Toukhy, Sherif Abdel-Rahman, Z. El-Kholy, H. Farag, S. El-Zoghby, N. Gaber

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The in-vivo effect of the schistosomicidal drugs praziquantel and oltipraz on the activities of the liver lysosomal enzymes in Schistosoma mansoni-infected and non-infected mice was studied. The effect of S. mansoni infection and the administration of the schistosomicidal drugs on the activities of β-glucuronidase, acid ribonuclease and α-naphthyl acetate esterases may be considered as indices for carcinogenicity. Drugs were given orally in subcurative doses, either in a single dose of 400 mg kg-1 for praziquantel or in five daily doses of 50 mg kg-1 oltipraz. The increase in enzymatic activities in infected animals was attributed to deranged metabolic function as a result of liver cell injury. Treatment of uninfected animals with either praziquantel or oltipraz significantly increased the activities of the three Iysosomal enzymes. Praziquantel possesses reversible and less toxic effects on the liver than oltipraz. The role of these antischistosomal drugs cannot be ignored as a possible aetiological factor implicated in the process of carcinogenesis associated with schistosomiasis infection through modulation of the operating potential of the enzymes concerned with detoxification, protein and fat metabolism.

Original languageEnglish (US)
Pages (from-to)28-34
Number of pages7
JournalJournal of Tropical Medicine and Hygiene
Volume96
Issue number1
StatePublished - 1993
Externally publishedYes

Fingerprint

Praziquantel
Liver
drug
experimental study
Enzymes
enzyme
Animals
Pharmaceutical Preparations
Detoxification
Acetylesterase
Oils and fats
schistosomiasis
Metabolism
Schistosomiasis mansoni
Schistosoma mansoni
animal
Poisons
Schistosomiasis
Glucuronidase
Ribonucleases

Keywords

  • Lysosomal enzymes
  • Oltipraz
  • Praziquantel
  • Schistosoma mansoni infection

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

El-Sharkawy, A., El-Toukhy, M., Abdel-Rahman, S., El-Kholy, Z., Farag, H., El-Zoghby, S., & Gaber, N. (1993). An experimental study on the effect of praziquantel and oltipraz on some lysosomal enzymes. Journal of Tropical Medicine and Hygiene, 96(1), 28-34.

An experimental study on the effect of praziquantel and oltipraz on some lysosomal enzymes. / El-Sharkawy, A.; El-Toukhy, M.; Abdel-Rahman, Sherif; El-Kholy, Z.; Farag, H.; El-Zoghby, S.; Gaber, N.

In: Journal of Tropical Medicine and Hygiene, Vol. 96, No. 1, 1993, p. 28-34.

Research output: Contribution to journalArticle

El-Sharkawy, A, El-Toukhy, M, Abdel-Rahman, S, El-Kholy, Z, Farag, H, El-Zoghby, S & Gaber, N 1993, 'An experimental study on the effect of praziquantel and oltipraz on some lysosomal enzymes', Journal of Tropical Medicine and Hygiene, vol. 96, no. 1, pp. 28-34.
El-Sharkawy, A. ; El-Toukhy, M. ; Abdel-Rahman, Sherif ; El-Kholy, Z. ; Farag, H. ; El-Zoghby, S. ; Gaber, N. / An experimental study on the effect of praziquantel and oltipraz on some lysosomal enzymes. In: Journal of Tropical Medicine and Hygiene. 1993 ; Vol. 96, No. 1. pp. 28-34.
@article{530250094f8f47b4b1020f62b23e8380,
title = "An experimental study on the effect of praziquantel and oltipraz on some lysosomal enzymes",
abstract = "The in-vivo effect of the schistosomicidal drugs praziquantel and oltipraz on the activities of the liver lysosomal enzymes in Schistosoma mansoni-infected and non-infected mice was studied. The effect of S. mansoni infection and the administration of the schistosomicidal drugs on the activities of β-glucuronidase, acid ribonuclease and α-naphthyl acetate esterases may be considered as indices for carcinogenicity. Drugs were given orally in subcurative doses, either in a single dose of 400 mg kg-1 for praziquantel or in five daily doses of 50 mg kg-1 oltipraz. The increase in enzymatic activities in infected animals was attributed to deranged metabolic function as a result of liver cell injury. Treatment of uninfected animals with either praziquantel or oltipraz significantly increased the activities of the three Iysosomal enzymes. Praziquantel possesses reversible and less toxic effects on the liver than oltipraz. The role of these antischistosomal drugs cannot be ignored as a possible aetiological factor implicated in the process of carcinogenesis associated with schistosomiasis infection through modulation of the operating potential of the enzymes concerned with detoxification, protein and fat metabolism.",
keywords = "Lysosomal enzymes, Oltipraz, Praziquantel, Schistosoma mansoni infection",
author = "A. El-Sharkawy and M. El-Toukhy and Sherif Abdel-Rahman and Z. El-Kholy and H. Farag and S. El-Zoghby and N. Gaber",
year = "1993",
language = "English (US)",
volume = "96",
pages = "28--34",
journal = "Journal of Tropical Medicine and Hygiene",
issn = "0022-5304",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - An experimental study on the effect of praziquantel and oltipraz on some lysosomal enzymes

AU - El-Sharkawy, A.

AU - El-Toukhy, M.

AU - Abdel-Rahman, Sherif

AU - El-Kholy, Z.

AU - Farag, H.

AU - El-Zoghby, S.

AU - Gaber, N.

PY - 1993

Y1 - 1993

N2 - The in-vivo effect of the schistosomicidal drugs praziquantel and oltipraz on the activities of the liver lysosomal enzymes in Schistosoma mansoni-infected and non-infected mice was studied. The effect of S. mansoni infection and the administration of the schistosomicidal drugs on the activities of β-glucuronidase, acid ribonuclease and α-naphthyl acetate esterases may be considered as indices for carcinogenicity. Drugs were given orally in subcurative doses, either in a single dose of 400 mg kg-1 for praziquantel or in five daily doses of 50 mg kg-1 oltipraz. The increase in enzymatic activities in infected animals was attributed to deranged metabolic function as a result of liver cell injury. Treatment of uninfected animals with either praziquantel or oltipraz significantly increased the activities of the three Iysosomal enzymes. Praziquantel possesses reversible and less toxic effects on the liver than oltipraz. The role of these antischistosomal drugs cannot be ignored as a possible aetiological factor implicated in the process of carcinogenesis associated with schistosomiasis infection through modulation of the operating potential of the enzymes concerned with detoxification, protein and fat metabolism.

AB - The in-vivo effect of the schistosomicidal drugs praziquantel and oltipraz on the activities of the liver lysosomal enzymes in Schistosoma mansoni-infected and non-infected mice was studied. The effect of S. mansoni infection and the administration of the schistosomicidal drugs on the activities of β-glucuronidase, acid ribonuclease and α-naphthyl acetate esterases may be considered as indices for carcinogenicity. Drugs were given orally in subcurative doses, either in a single dose of 400 mg kg-1 for praziquantel or in five daily doses of 50 mg kg-1 oltipraz. The increase in enzymatic activities in infected animals was attributed to deranged metabolic function as a result of liver cell injury. Treatment of uninfected animals with either praziquantel or oltipraz significantly increased the activities of the three Iysosomal enzymes. Praziquantel possesses reversible and less toxic effects on the liver than oltipraz. The role of these antischistosomal drugs cannot be ignored as a possible aetiological factor implicated in the process of carcinogenesis associated with schistosomiasis infection through modulation of the operating potential of the enzymes concerned with detoxification, protein and fat metabolism.

KW - Lysosomal enzymes

KW - Oltipraz

KW - Praziquantel

KW - Schistosoma mansoni infection

UR - http://www.scopus.com/inward/record.url?scp=0027521041&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027521041&partnerID=8YFLogxK

M3 - Article

VL - 96

SP - 28

EP - 34

JO - Journal of Tropical Medicine and Hygiene

JF - Journal of Tropical Medicine and Hygiene

SN - 0022-5304

IS - 1

ER -