An influenza outbreak due to a/USSR/77-like (h1n1) virus aboard a us navy ship

Thomas Ksiazek, J. G. Olson, G. S. Irving, C. S. Settle, R. White, R. Petrusso

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

An explosive outbreak of influenza caused by an A/USSR/77-like (H1N1) virus occurred aboard a US Navy ship in December 1977 and January 1978. Two hundred volunteers aboard the ship were studied. Virus was isolated from 36 of 57 patients from whom isolation was attempted. Among virologically confirmed patients, headache (97%), chills (92%), malaise (86%), and cough (75%) were the most frequent symptoms. There were two virologically confirmed cases with complications: one with collapsed lung and the other with pneumonitis. The study subjects were 25 years of age or less, but there was little influenza-like disease in members of the crew greater than 25 years of age. Prior vaccination with bivalent vaccine, containing A/NJ/76 (Hsw1N1) virus, did not offer significant protection against disease caused by A/USSR/77-like virus. Serologic tests, either or both complement fixation and hemagglutination inhibition, were positive in only 14 of 22 virologically confirmed cases, indicating a poor serologic response to primary infection with this strain of virus. These findings prevented calculation of meaningful disease to infection ratios. However, inapparent infection occurred in 3 of 19 (16%) individuals who denied having illness during the outbreak yet had serologic evidence of recent influenza infection.

Original languageEnglish (US)
Pages (from-to)487-494
Number of pages8
JournalAmerican Journal of Epidemiology
Volume112
Issue number4
StatePublished - Oct 1980
Externally publishedYes

Fingerprint

H1N1 Subtype Influenza A Virus
Ships
USSR
Human Influenza
Disease Outbreaks
Viruses
Infection
Patient Isolation
Chills
Hemagglutination
Serologic Tests
Cough
Headache
Volunteers
Pneumonia
Vaccination
Vaccines
Lung

Keywords

  • Antibodies
  • Hemagglutinins
  • Influenza
  • Orthomyxoviruses
  • Respiratory tract infections
  • Viral

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Epidemiology

Cite this

Ksiazek, T., Olson, J. G., Irving, G. S., Settle, C. S., White, R., & Petrusso, R. (1980). An influenza outbreak due to a/USSR/77-like (h1n1) virus aboard a us navy ship. American Journal of Epidemiology, 112(4), 487-494.

An influenza outbreak due to a/USSR/77-like (h1n1) virus aboard a us navy ship. / Ksiazek, Thomas; Olson, J. G.; Irving, G. S.; Settle, C. S.; White, R.; Petrusso, R.

In: American Journal of Epidemiology, Vol. 112, No. 4, 10.1980, p. 487-494.

Research output: Contribution to journalArticle

Ksiazek, T, Olson, JG, Irving, GS, Settle, CS, White, R & Petrusso, R 1980, 'An influenza outbreak due to a/USSR/77-like (h1n1) virus aboard a us navy ship', American Journal of Epidemiology, vol. 112, no. 4, pp. 487-494.
Ksiazek T, Olson JG, Irving GS, Settle CS, White R, Petrusso R. An influenza outbreak due to a/USSR/77-like (h1n1) virus aboard a us navy ship. American Journal of Epidemiology. 1980 Oct;112(4):487-494.
Ksiazek, Thomas ; Olson, J. G. ; Irving, G. S. ; Settle, C. S. ; White, R. ; Petrusso, R. / An influenza outbreak due to a/USSR/77-like (h1n1) virus aboard a us navy ship. In: American Journal of Epidemiology. 1980 ; Vol. 112, No. 4. pp. 487-494.
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