An influenza virus inhibitor that acts late in the replication cycle

G. Antonelli, F. Dianzani, D. H. Coppenhaver, S. Baron, P. Calandra, G. Folchitto

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

An inhibitor which is active against influenza A virus was found in Neuramide, a complex tissue extract that is used as an anti-herpes zoster virus treatment. Kinetic studies showed that significant inhibition of virus production occurred when the inhibitor was added to infected cultures up to 5 h after virus penetration. Molecular sieving fractionation showed that the antiviral activity was contained in a low-molecular-weight fraction (molecular weight, <1,000).

Original languageEnglish (US)
Pages (from-to)49-51
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume29
Issue number1
StatePublished - 1986

Fingerprint

Orthomyxoviridae
Molecular Weight
Viruses
Human Herpesvirus 3
Tissue Extracts
Influenza A virus
Complex Mixtures
Antiviral Agents
neuramide

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Antonelli, G., Dianzani, F., Coppenhaver, D. H., Baron, S., Calandra, P., & Folchitto, G. (1986). An influenza virus inhibitor that acts late in the replication cycle. Antimicrobial Agents and Chemotherapy, 29(1), 49-51.

An influenza virus inhibitor that acts late in the replication cycle. / Antonelli, G.; Dianzani, F.; Coppenhaver, D. H.; Baron, S.; Calandra, P.; Folchitto, G.

In: Antimicrobial Agents and Chemotherapy, Vol. 29, No. 1, 1986, p. 49-51.

Research output: Contribution to journalArticle

Antonelli, G, Dianzani, F, Coppenhaver, DH, Baron, S, Calandra, P & Folchitto, G 1986, 'An influenza virus inhibitor that acts late in the replication cycle', Antimicrobial Agents and Chemotherapy, vol. 29, no. 1, pp. 49-51.
Antonelli G, Dianzani F, Coppenhaver DH, Baron S, Calandra P, Folchitto G. An influenza virus inhibitor that acts late in the replication cycle. Antimicrobial Agents and Chemotherapy. 1986;29(1):49-51.
Antonelli, G. ; Dianzani, F. ; Coppenhaver, D. H. ; Baron, S. ; Calandra, P. ; Folchitto, G. / An influenza virus inhibitor that acts late in the replication cycle. In: Antimicrobial Agents and Chemotherapy. 1986 ; Vol. 29, No. 1. pp. 49-51.
@article{c5d81465ab354913b06847f5df378f6d,
title = "An influenza virus inhibitor that acts late in the replication cycle",
abstract = "An inhibitor which is active against influenza A virus was found in Neuramide, a complex tissue extract that is used as an anti-herpes zoster virus treatment. Kinetic studies showed that significant inhibition of virus production occurred when the inhibitor was added to infected cultures up to 5 h after virus penetration. Molecular sieving fractionation showed that the antiviral activity was contained in a low-molecular-weight fraction (molecular weight, <1,000).",
author = "G. Antonelli and F. Dianzani and Coppenhaver, {D. H.} and S. Baron and P. Calandra and G. Folchitto",
year = "1986",
language = "English (US)",
volume = "29",
pages = "49--51",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "1",

}

TY - JOUR

T1 - An influenza virus inhibitor that acts late in the replication cycle

AU - Antonelli, G.

AU - Dianzani, F.

AU - Coppenhaver, D. H.

AU - Baron, S.

AU - Calandra, P.

AU - Folchitto, G.

PY - 1986

Y1 - 1986

N2 - An inhibitor which is active against influenza A virus was found in Neuramide, a complex tissue extract that is used as an anti-herpes zoster virus treatment. Kinetic studies showed that significant inhibition of virus production occurred when the inhibitor was added to infected cultures up to 5 h after virus penetration. Molecular sieving fractionation showed that the antiviral activity was contained in a low-molecular-weight fraction (molecular weight, <1,000).

AB - An inhibitor which is active against influenza A virus was found in Neuramide, a complex tissue extract that is used as an anti-herpes zoster virus treatment. Kinetic studies showed that significant inhibition of virus production occurred when the inhibitor was added to infected cultures up to 5 h after virus penetration. Molecular sieving fractionation showed that the antiviral activity was contained in a low-molecular-weight fraction (molecular weight, <1,000).

UR - http://www.scopus.com/inward/record.url?scp=0022651445&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022651445&partnerID=8YFLogxK

M3 - Article

C2 - 3755313

AN - SCOPUS:0022651445

VL - 29

SP - 49

EP - 51

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 1

ER -