An influenza virus inhibitor that acts late in the replication cycle

G. Antonelli, F. Dianzani, D. H. Coppenhaver, S. Baron, P. Calandra, G. Folchitto

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Abstract

An inhibitor which is active against influenza A virus was found in Neuramide, a complex tissue extract that is used as an anti-herpes zoster virus treatment. Kinetic studies showed that significant inhibition of virus production occurred when the inhibitor was added to infected cultures up to 5 h after virus penetration. Molecular sieving fractionation showed that the antiviral activity was contained in a low-molecular-weight fraction (molecular weight, <1,000).

Original languageEnglish (US)
Pages (from-to)49-51
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume29
Issue number1
DOIs
StatePublished - Jan 1 1986

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Antonelli, G., Dianzani, F., Coppenhaver, D. H., Baron, S., Calandra, P., & Folchitto, G. (1986). An influenza virus inhibitor that acts late in the replication cycle. Antimicrobial Agents and Chemotherapy, 29(1), 49-51. https://doi.org/10.1128/AAC.29.1.49