An international study on the use of peroral endoscopic myotomy in the management of Zenker's diverticulum

Juliana Yang, Stephanie Novak, Michael Ujiki, Óscar Hernández, Pankaj Desai, Petros Benias, David Lee, Kenneth Chang, Bertrand Brieau, Maximilien Barret, Nikhil Kumta, Xianhui Zeng, Bing Hu, Konstantinos Delis, Mouen A. Khashab

Research output: Contribution to journalArticlepeer-review

88 Scopus citations


Background and Aims: The novel use of peroral endoscopic myotomy (POEM) in the treatment of Zenker's diverticulum (ZD) was recently described in case reports. The aim of this study is to report a multicenter experience with the POEM technique in the management of ZD. Methods: This is a multicenter international retrospective study involving 10 centers. The Zenker's POEM technique was performed using principles of submucosal endoscopy. Results: Seventy-five patients (73.3 ± 1.2 years, 33 women) were included with a mean Charleson comorbidity index of 4 ±.2. The mean size of ZD was 31.3 ± 1.6 mm (range, 10-89). The overall technical success rate was 97.3% (73/75). There were 2 technical failures because of the inability to locate the septum and failed tunnel creation. Adverse events occurred in 6.7% (5/75): 1 bleed (mild) conservatively managed and 4 perforations (1 severe, 3 moderate). The mean procedure time was 52.4 ± 2.9 minutes, and mean length of hospital stay was 1.8 ±.2 days. Clinical success was achieved in 92% (69/75) with a decrease in mean dysphagia score from 1.96 to.25 (P <.0001). The median length of follow-up was 291.5 days (interquartile range, 103.5-436). At the 12-month follow-up, 1 patient reported symptom recurrence. Conclusions: Endoscopic management of ZD using the POEM technique is novel and feasible with promising efficacy and safety results. Long-term follow-up is needed to ensure durability of response. In addition, comparative studies with other treatment modalities are warranted.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalGastrointestinal endoscopy
Issue number1
StatePublished - Jan 2020
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology


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