An Outbreak of Ebola Virus Disease in the Lassa Fever Zone

Augustine Goba, S. Humarr Khan, Mbalu Fonnie, Mohamed Fullah, Alex Moigboi, Alice Kovoma, Vandi Sinnah, Nancy Yoko, Hawa Rogers, Siddiki Safai, Mambu Momoh, Veronica Koroma, Fatima K. Kamara, Edwin Konowu, Mohamed Yillah, Issa French, Ibraham Mustapha, Franklyn Kanneh, Momoh Foday, Helena McCarthy & 64 others Tiangay Kallon, Mustupha Kallon, Jenneh Naiebu, Josephine Sellu, Abdul A. Jalloh, Michael Gbakie, Lansana Kanneh, James L B Massaly, David Kargbo, Brima Kargbo, Mohamed Vandi, Momoh Gbetuwa, Sahr M. Gevao, John D. Sandi, Simbirie C. Jalloh, Donald S. Grant, Sylvia O. Blyden, Ian Crozier, John S. Schieffelin, Susan McLellan, Shevin T. Jacob, Matt L. Boisen, Jessica N. Hartnett, Robert Cross, Luis M. Branco, Kristian G. Andersen, Nathan L. Yozwiak, Stephen K. Gire, Ridhi Tariyal, Daniel J. Park, Allyson M. Haislip, Christopher M. Bishop, Lilia I. Melnik, William R. Gallaher, William C. Wimley, Jing He, Jeffrey G. Shaffer, Brian M. Sullivan, Sonia Grillo, Scott Oman, Courtney E. Garry, Donna R. Edwards, Stephanie J. McCormick, Deborah H. Elliott, Julie A. Rouelle, Chandrika B. Kannadka, Ashley A. Reyna, Benjamin T. Bradley, Haini Yu, Rachael E. Yenni, Kathryn M. Hastie, Joan B. Geisbert, Peter C. Kulakosky, Russell B. Wilson, Michael B A Oldstone, Kelly R. Pitts, Lee A. Henderson, James E. Robinson, Thomas Geisbert, Erica Ollmann Saphire, Christian T. Happi, Danny A. Asogun, Pardis C. Sabeti, Robert F. Garry

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background. Kenema Government Hospital (KGH) has developed an advanced clinical and laboratory research capacity to manage the threat of Lassa fever, a viral hemorrhagic fever (VHF). The 2013-2016 Ebola virus (EBOV) disease (EVD) outbreak is the first to have occurred in an area close to a facility with established clinical and laboratory capacity for study of VHFs. Methods. Because of its proximity to the epicenter of the EVD outbreak, which began in Guinea in March 2014, the KGH Lassa fever Team mobilized to establish EBOV surveillance and diagnostic capabilities. Results. Augustine Goba, director of the KGH Lassa laboratory, diagnosed the first documented case of EVD in Sierra Leone, on 25 May 2014. Thereafter, KGH received and cared for numbers of patients with EVD that quickly overwhelmed the capacity for safe management. Numerous healthcare workers contracted and lost their lives to EVD. The vast majority of subsequent EVD cases in West Africa can be traced back to a single transmission chain that includes this first diagnosed case. Conclusions. Responding to the challenges of confronting 2 hemorrhagic fever viruses will require continued investments in the development of countermeasures (vaccines, therapeutic agents, and diagnostic assays), infrastructure, and human resources.

Original languageEnglish (US)
Pages (from-to)S110-S121
JournalJournal of Infectious Diseases
Volume214
DOIs
StatePublished - Oct 15 2016

Fingerprint

Ebola Hemorrhagic Fever
Lassa Fever
Disease Outbreaks
Viral Hemorrhagic Fevers
Sierra Leone
Ebolavirus
Guinea
Hospital Laboratories
Western Africa
Fever
Vaccines
Viruses
Delivery of Health Care
Research

Keywords

  • Ebola virus
  • Epidemiology
  • Genomic sequencing
  • Lassa virus
  • Research capacity building
  • Viral hemorrhagic fever diagnostics
  • West African Ebola outbreak 2013-16

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Goba, A., Khan, S. H., Fonnie, M., Fullah, M., Moigboi, A., Kovoma, A., ... Garry, R. F. (2016). An Outbreak of Ebola Virus Disease in the Lassa Fever Zone. Journal of Infectious Diseases, 214, S110-S121. https://doi.org/10.1093/infdis/jiw239

An Outbreak of Ebola Virus Disease in the Lassa Fever Zone. / Goba, Augustine; Khan, S. Humarr; Fonnie, Mbalu; Fullah, Mohamed; Moigboi, Alex; Kovoma, Alice; Sinnah, Vandi; Yoko, Nancy; Rogers, Hawa; Safai, Siddiki; Momoh, Mambu; Koroma, Veronica; Kamara, Fatima K.; Konowu, Edwin; Yillah, Mohamed; French, Issa; Mustapha, Ibraham; Kanneh, Franklyn; Foday, Momoh; McCarthy, Helena; Kallon, Tiangay; Kallon, Mustupha; Naiebu, Jenneh; Sellu, Josephine; Jalloh, Abdul A.; Gbakie, Michael; Kanneh, Lansana; Massaly, James L B; Kargbo, David; Kargbo, Brima; Vandi, Mohamed; Gbetuwa, Momoh; Gevao, Sahr M.; Sandi, John D.; Jalloh, Simbirie C.; Grant, Donald S.; Blyden, Sylvia O.; Crozier, Ian; Schieffelin, John S.; McLellan, Susan; Jacob, Shevin T.; Boisen, Matt L.; Hartnett, Jessica N.; Cross, Robert; Branco, Luis M.; Andersen, Kristian G.; Yozwiak, Nathan L.; Gire, Stephen K.; Tariyal, Ridhi; Park, Daniel J.; Haislip, Allyson M.; Bishop, Christopher M.; Melnik, Lilia I.; Gallaher, William R.; Wimley, William C.; He, Jing; Shaffer, Jeffrey G.; Sullivan, Brian M.; Grillo, Sonia; Oman, Scott; Garry, Courtney E.; Edwards, Donna R.; McCormick, Stephanie J.; Elliott, Deborah H.; Rouelle, Julie A.; Kannadka, Chandrika B.; Reyna, Ashley A.; Bradley, Benjamin T.; Yu, Haini; Yenni, Rachael E.; Hastie, Kathryn M.; Geisbert, Joan B.; Kulakosky, Peter C.; Wilson, Russell B.; Oldstone, Michael B A; Pitts, Kelly R.; Henderson, Lee A.; Robinson, James E.; Geisbert, Thomas; Saphire, Erica Ollmann; Happi, Christian T.; Asogun, Danny A.; Sabeti, Pardis C.; Garry, Robert F.

In: Journal of Infectious Diseases, Vol. 214, 15.10.2016, p. S110-S121.

Research output: Contribution to journalArticle

Goba, A, Khan, SH, Fonnie, M, Fullah, M, Moigboi, A, Kovoma, A, Sinnah, V, Yoko, N, Rogers, H, Safai, S, Momoh, M, Koroma, V, Kamara, FK, Konowu, E, Yillah, M, French, I, Mustapha, I, Kanneh, F, Foday, M, McCarthy, H, Kallon, T, Kallon, M, Naiebu, J, Sellu, J, Jalloh, AA, Gbakie, M, Kanneh, L, Massaly, JLB, Kargbo, D, Kargbo, B, Vandi, M, Gbetuwa, M, Gevao, SM, Sandi, JD, Jalloh, SC, Grant, DS, Blyden, SO, Crozier, I, Schieffelin, JS, McLellan, S, Jacob, ST, Boisen, ML, Hartnett, JN, Cross, R, Branco, LM, Andersen, KG, Yozwiak, NL, Gire, SK, Tariyal, R, Park, DJ, Haislip, AM, Bishop, CM, Melnik, LI, Gallaher, WR, Wimley, WC, He, J, Shaffer, JG, Sullivan, BM, Grillo, S, Oman, S, Garry, CE, Edwards, DR, McCormick, SJ, Elliott, DH, Rouelle, JA, Kannadka, CB, Reyna, AA, Bradley, BT, Yu, H, Yenni, RE, Hastie, KM, Geisbert, JB, Kulakosky, PC, Wilson, RB, Oldstone, MBA, Pitts, KR, Henderson, LA, Robinson, JE, Geisbert, T, Saphire, EO, Happi, CT, Asogun, DA, Sabeti, PC & Garry, RF 2016, 'An Outbreak of Ebola Virus Disease in the Lassa Fever Zone', Journal of Infectious Diseases, vol. 214, pp. S110-S121. https://doi.org/10.1093/infdis/jiw239
Goba A, Khan SH, Fonnie M, Fullah M, Moigboi A, Kovoma A et al. An Outbreak of Ebola Virus Disease in the Lassa Fever Zone. Journal of Infectious Diseases. 2016 Oct 15;214:S110-S121. https://doi.org/10.1093/infdis/jiw239
Goba, Augustine ; Khan, S. Humarr ; Fonnie, Mbalu ; Fullah, Mohamed ; Moigboi, Alex ; Kovoma, Alice ; Sinnah, Vandi ; Yoko, Nancy ; Rogers, Hawa ; Safai, Siddiki ; Momoh, Mambu ; Koroma, Veronica ; Kamara, Fatima K. ; Konowu, Edwin ; Yillah, Mohamed ; French, Issa ; Mustapha, Ibraham ; Kanneh, Franklyn ; Foday, Momoh ; McCarthy, Helena ; Kallon, Tiangay ; Kallon, Mustupha ; Naiebu, Jenneh ; Sellu, Josephine ; Jalloh, Abdul A. ; Gbakie, Michael ; Kanneh, Lansana ; Massaly, James L B ; Kargbo, David ; Kargbo, Brima ; Vandi, Mohamed ; Gbetuwa, Momoh ; Gevao, Sahr M. ; Sandi, John D. ; Jalloh, Simbirie C. ; Grant, Donald S. ; Blyden, Sylvia O. ; Crozier, Ian ; Schieffelin, John S. ; McLellan, Susan ; Jacob, Shevin T. ; Boisen, Matt L. ; Hartnett, Jessica N. ; Cross, Robert ; Branco, Luis M. ; Andersen, Kristian G. ; Yozwiak, Nathan L. ; Gire, Stephen K. ; Tariyal, Ridhi ; Park, Daniel J. ; Haislip, Allyson M. ; Bishop, Christopher M. ; Melnik, Lilia I. ; Gallaher, William R. ; Wimley, William C. ; He, Jing ; Shaffer, Jeffrey G. ; Sullivan, Brian M. ; Grillo, Sonia ; Oman, Scott ; Garry, Courtney E. ; Edwards, Donna R. ; McCormick, Stephanie J. ; Elliott, Deborah H. ; Rouelle, Julie A. ; Kannadka, Chandrika B. ; Reyna, Ashley A. ; Bradley, Benjamin T. ; Yu, Haini ; Yenni, Rachael E. ; Hastie, Kathryn M. ; Geisbert, Joan B. ; Kulakosky, Peter C. ; Wilson, Russell B. ; Oldstone, Michael B A ; Pitts, Kelly R. ; Henderson, Lee A. ; Robinson, James E. ; Geisbert, Thomas ; Saphire, Erica Ollmann ; Happi, Christian T. ; Asogun, Danny A. ; Sabeti, Pardis C. ; Garry, Robert F. / An Outbreak of Ebola Virus Disease in the Lassa Fever Zone. In: Journal of Infectious Diseases. 2016 ; Vol. 214. pp. S110-S121.
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title = "An Outbreak of Ebola Virus Disease in the Lassa Fever Zone",
abstract = "Background. Kenema Government Hospital (KGH) has developed an advanced clinical and laboratory research capacity to manage the threat of Lassa fever, a viral hemorrhagic fever (VHF). The 2013-2016 Ebola virus (EBOV) disease (EVD) outbreak is the first to have occurred in an area close to a facility with established clinical and laboratory capacity for study of VHFs. Methods. Because of its proximity to the epicenter of the EVD outbreak, which began in Guinea in March 2014, the KGH Lassa fever Team mobilized to establish EBOV surveillance and diagnostic capabilities. Results. Augustine Goba, director of the KGH Lassa laboratory, diagnosed the first documented case of EVD in Sierra Leone, on 25 May 2014. Thereafter, KGH received and cared for numbers of patients with EVD that quickly overwhelmed the capacity for safe management. Numerous healthcare workers contracted and lost their lives to EVD. The vast majority of subsequent EVD cases in West Africa can be traced back to a single transmission chain that includes this first diagnosed case. Conclusions. Responding to the challenges of confronting 2 hemorrhagic fever viruses will require continued investments in the development of countermeasures (vaccines, therapeutic agents, and diagnostic assays), infrastructure, and human resources.",
keywords = "Ebola virus, Epidemiology, Genomic sequencing, Lassa virus, Research capacity building, Viral hemorrhagic fever diagnostics, West African Ebola outbreak 2013-16",
author = "Augustine Goba and Khan, {S. Humarr} and Mbalu Fonnie and Mohamed Fullah and Alex Moigboi and Alice Kovoma and Vandi Sinnah and Nancy Yoko and Hawa Rogers and Siddiki Safai and Mambu Momoh and Veronica Koroma and Kamara, {Fatima K.} and Edwin Konowu and Mohamed Yillah and Issa French and Ibraham Mustapha and Franklyn Kanneh and Momoh Foday and Helena McCarthy and Tiangay Kallon and Mustupha Kallon and Jenneh Naiebu and Josephine Sellu and Jalloh, {Abdul A.} and Michael Gbakie and Lansana Kanneh and Massaly, {James L B} and David Kargbo and Brima Kargbo and Mohamed Vandi and Momoh Gbetuwa and Gevao, {Sahr M.} and Sandi, {John D.} and Jalloh, {Simbirie C.} and Grant, {Donald S.} and Blyden, {Sylvia O.} and Ian Crozier and Schieffelin, {John S.} and Susan McLellan and Jacob, {Shevin T.} and Boisen, {Matt L.} and Hartnett, {Jessica N.} and Robert Cross and Branco, {Luis M.} and Andersen, {Kristian G.} and Yozwiak, {Nathan L.} and Gire, {Stephen K.} and Ridhi Tariyal and Park, {Daniel J.} and Haislip, {Allyson M.} and Bishop, {Christopher M.} and Melnik, {Lilia I.} and Gallaher, {William R.} and Wimley, {William C.} and Jing He and Shaffer, {Jeffrey G.} and Sullivan, {Brian M.} and Sonia Grillo and Scott Oman and Garry, {Courtney E.} and Edwards, {Donna R.} and McCormick, {Stephanie J.} and Elliott, {Deborah H.} and Rouelle, {Julie A.} and Kannadka, {Chandrika B.} and Reyna, {Ashley A.} and Bradley, {Benjamin T.} and Haini Yu and Yenni, {Rachael E.} and Hastie, {Kathryn M.} and Geisbert, {Joan B.} and Kulakosky, {Peter C.} and Wilson, {Russell B.} and Oldstone, {Michael B A} and Pitts, {Kelly R.} and Henderson, {Lee A.} and Robinson, {James E.} and Thomas Geisbert and Saphire, {Erica Ollmann} and Happi, {Christian T.} and Asogun, {Danny A.} and Sabeti, {Pardis C.} and Garry, {Robert F.}",
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TY - JOUR

T1 - An Outbreak of Ebola Virus Disease in the Lassa Fever Zone

AU - Goba, Augustine

AU - Khan, S. Humarr

AU - Fonnie, Mbalu

AU - Fullah, Mohamed

AU - Moigboi, Alex

AU - Kovoma, Alice

AU - Sinnah, Vandi

AU - Yoko, Nancy

AU - Rogers, Hawa

AU - Safai, Siddiki

AU - Momoh, Mambu

AU - Koroma, Veronica

AU - Kamara, Fatima K.

AU - Konowu, Edwin

AU - Yillah, Mohamed

AU - French, Issa

AU - Mustapha, Ibraham

AU - Kanneh, Franklyn

AU - Foday, Momoh

AU - McCarthy, Helena

AU - Kallon, Tiangay

AU - Kallon, Mustupha

AU - Naiebu, Jenneh

AU - Sellu, Josephine

AU - Jalloh, Abdul A.

AU - Gbakie, Michael

AU - Kanneh, Lansana

AU - Massaly, James L B

AU - Kargbo, David

AU - Kargbo, Brima

AU - Vandi, Mohamed

AU - Gbetuwa, Momoh

AU - Gevao, Sahr M.

AU - Sandi, John D.

AU - Jalloh, Simbirie C.

AU - Grant, Donald S.

AU - Blyden, Sylvia O.

AU - Crozier, Ian

AU - Schieffelin, John S.

AU - McLellan, Susan

AU - Jacob, Shevin T.

AU - Boisen, Matt L.

AU - Hartnett, Jessica N.

AU - Cross, Robert

AU - Branco, Luis M.

AU - Andersen, Kristian G.

AU - Yozwiak, Nathan L.

AU - Gire, Stephen K.

AU - Tariyal, Ridhi

AU - Park, Daniel J.

AU - Haislip, Allyson M.

AU - Bishop, Christopher M.

AU - Melnik, Lilia I.

AU - Gallaher, William R.

AU - Wimley, William C.

AU - He, Jing

AU - Shaffer, Jeffrey G.

AU - Sullivan, Brian M.

AU - Grillo, Sonia

AU - Oman, Scott

AU - Garry, Courtney E.

AU - Edwards, Donna R.

AU - McCormick, Stephanie J.

AU - Elliott, Deborah H.

AU - Rouelle, Julie A.

AU - Kannadka, Chandrika B.

AU - Reyna, Ashley A.

AU - Bradley, Benjamin T.

AU - Yu, Haini

AU - Yenni, Rachael E.

AU - Hastie, Kathryn M.

AU - Geisbert, Joan B.

AU - Kulakosky, Peter C.

AU - Wilson, Russell B.

AU - Oldstone, Michael B A

AU - Pitts, Kelly R.

AU - Henderson, Lee A.

AU - Robinson, James E.

AU - Geisbert, Thomas

AU - Saphire, Erica Ollmann

AU - Happi, Christian T.

AU - Asogun, Danny A.

AU - Sabeti, Pardis C.

AU - Garry, Robert F.

PY - 2016/10/15

Y1 - 2016/10/15

N2 - Background. Kenema Government Hospital (KGH) has developed an advanced clinical and laboratory research capacity to manage the threat of Lassa fever, a viral hemorrhagic fever (VHF). The 2013-2016 Ebola virus (EBOV) disease (EVD) outbreak is the first to have occurred in an area close to a facility with established clinical and laboratory capacity for study of VHFs. Methods. Because of its proximity to the epicenter of the EVD outbreak, which began in Guinea in March 2014, the KGH Lassa fever Team mobilized to establish EBOV surveillance and diagnostic capabilities. Results. Augustine Goba, director of the KGH Lassa laboratory, diagnosed the first documented case of EVD in Sierra Leone, on 25 May 2014. Thereafter, KGH received and cared for numbers of patients with EVD that quickly overwhelmed the capacity for safe management. Numerous healthcare workers contracted and lost their lives to EVD. The vast majority of subsequent EVD cases in West Africa can be traced back to a single transmission chain that includes this first diagnosed case. Conclusions. Responding to the challenges of confronting 2 hemorrhagic fever viruses will require continued investments in the development of countermeasures (vaccines, therapeutic agents, and diagnostic assays), infrastructure, and human resources.

AB - Background. Kenema Government Hospital (KGH) has developed an advanced clinical and laboratory research capacity to manage the threat of Lassa fever, a viral hemorrhagic fever (VHF). The 2013-2016 Ebola virus (EBOV) disease (EVD) outbreak is the first to have occurred in an area close to a facility with established clinical and laboratory capacity for study of VHFs. Methods. Because of its proximity to the epicenter of the EVD outbreak, which began in Guinea in March 2014, the KGH Lassa fever Team mobilized to establish EBOV surveillance and diagnostic capabilities. Results. Augustine Goba, director of the KGH Lassa laboratory, diagnosed the first documented case of EVD in Sierra Leone, on 25 May 2014. Thereafter, KGH received and cared for numbers of patients with EVD that quickly overwhelmed the capacity for safe management. Numerous healthcare workers contracted and lost their lives to EVD. The vast majority of subsequent EVD cases in West Africa can be traced back to a single transmission chain that includes this first diagnosed case. Conclusions. Responding to the challenges of confronting 2 hemorrhagic fever viruses will require continued investments in the development of countermeasures (vaccines, therapeutic agents, and diagnostic assays), infrastructure, and human resources.

KW - Ebola virus

KW - Epidemiology

KW - Genomic sequencing

KW - Lassa virus

KW - Research capacity building

KW - Viral hemorrhagic fever diagnostics

KW - West African Ebola outbreak 2013-16

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DO - 10.1093/infdis/jiw239

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